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16 Possible Causes for Delayed Bone Age, Skeletal Dysplasia, Wide Space Between the First and Second Toe

  • Russell-Silver Syndrome

    A new skeletal dysplasia syndrome with rhizomelia of the humeri and other malformations. Clin Genet. 1986 Jan; 29 (1):83–87. [ PubMed ] [ Google Scholar ] Adeyokunnu AA.[ncbi.nlm.nih.gov] However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome

    Based on the clinical and radiological features showing evidence of skeletal dysplasia, the diagnosis was revised to Majewski osteodysplastic primordial dwarfism type II ([ncbi.nlm.nih.gov] bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Dubowitz Syndrome

    22q11.2 deletion syndrome Thanatophoric dysplasia type 2 Familial partial lipodystrophy Renal dysplasia, retinal pigmentary dystrophy, cerebellar ataxia and skeletal dysplasia[checkrare.com] Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    Hereditary skeletal dysplasia resulting in proportionate dwarfism characterized by thickening of the inner corticalis and stenosis of the medullary cavities of the tubular[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com] During the course of his fellowship, he initiated positional cloning studies of an autosomal recessive skeletal dysplasia, the Kenny-Caffey Syndrome (KCS), using eight consanguineous[grantome.com]

  • Seckel Syndrome Type 2

    Skeletal dysplasia extended panel ALPL, ARSE, COL10A1, COL11A1, COL11A2,...[centogene.com] bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    In the neonatal period, brachydactyly and facial dysmorphism are two early distinctive signs, later followed by intellectual disability and hyperostotic skeletal dysplasia[ncbi.nlm.nih.gov] Radiological investigation of the hand wrist bone showed a markedly delayed bone age.[karger.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Weaver Syndrome

    Key words Weaver Syndrome Accelerated skeletal maturation Bone dysplasia Congenital malformation This is a preview of subscription content, log in to check access.[link.springer.com] delay.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Multiple Epiphyseal Dysplasia - Severe Proximal Femoral Dysplasia

    dysplasias.[books.google.com] Hands: short, stubby fingers partial agenesis/aplasia of terminal phalanges, simulating acro-osteolysis delayed bone age Cranial and maxillofacial marked delay in sutural[slideshare.net] (C) Adduction of the right forefoot with wide spacing between the first and second toes. The left foot shows only mild shortening of the first toe.[jmg.bmj.com]

  • Short Stature - Wormian Bones - Dextrocardia Syndrome

    Sjogren's syndrome Skeletal dysplasia brachydactyly[?] Skeletal dysplasia epilepsy short stature[?] Skeletal dysplasia orofacial anomalies[?][encyclopedia.kids.net.au] bone age, facial dysmorphisms, and expressive language delays, indicative to a specific set of signs, symptoms or other health indicators, associated with short stature with[wellnessadvocate.com] Wide spacing between first and second toes ( Matthews and Robin, 2011 ). 3. Skin. a. Short neck with excess nuchal skin. C. Associated findings. 1. Prematurity. 2.[nursekey.com]

  • Trisomy 10p

    dysplasia - prominent ears LEOPARD Syndrome - prominent ears Lindstrom syndrome - prominent ears Lymphedema, microcephaly and chorioretinopathy syndrome - prominent ears[dumboearsinlouisiana.weebly.com] Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com]

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