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18 Possible Causes for Delayed Bone Age, Small Hand, Wide Space Between the First and Second Toe

  • Kenny-Caffey Syndrome Type 1

    Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature.[accessanesthesiology.mhmedical.com] hands and feet, hypocalcaemia, hypoparathyroidism, radiologic evidence of cortical thickening of long bones with medullary stenosis, and absent diploic space in the skull[medical-dictionary.thefreedictionary.com] space between the first and second toes.[medcraveonline.com]

  • Dubowitz Syndrome

    Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] […] feet [ more ] 0001773 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small hand Disproportionately small hands 0200055 Sparse lateral eyebrow Limited[rarediseases.info.nih.gov] Skeletal issues can be delayed bone age, fifth finger clinodactyly , two/three toe syndactyly , and pes planus . Some are very prone to eczema or have severe allergies.[dubowitzsyndrome.net]

  • Russell-Silver Syndrome

    However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal[ncbi.nlm.nih.gov] We report a small series of patients presenting with a range of hand anomalies, some of which have not been previously reported in association with this condition.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome

    bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] […] bones, with considerable similarity of the metacarpophalangeal pattern between the two children; (5) relatively small carpals, which have an angular configuration; and (6[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Ring Chromosome 10

    Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] During this process, cropenis, cryptorchidism, hypertelorism, epicanthic some of the genetic materials may be lost and fold, microgenathia and small hands (7).[docksci.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Short Stature due to Endocrine Disorder

    Other features may include delayed bone age, developmental delay, and dysmorphic features.[ncbi.nlm.nih.gov] […] feet [ more ] 0001773 Small hand Disproportionately small hands 0200055 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Synophrys Monobrow Unibrow [ more ] 0000664[rarediseases.info.nih.gov] Delayed puberty X-rays showing delayed bone development In adults, abnormally low levels of GH and/or IGF-1 may cause subtle, nonspecific symptoms such as: Decreased bone[labtestsonline.org]

  • Cutis Laxa

    Radiological investigation of the hand wrist bone showed a markedly delayed bone age.[karger.com] […] nails, and large hands and feet with deep creases on the palms and soles (fig 11 ).[jmg.bmj.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Weaver Syndrome

    delay.[ncbi.nlm.nih.gov] […] height, big hands and feet, hypertonia, umbilical hernia, weak bones and muscles, special skeletal structure and skeletal maturation etc.[rumeysagelgi.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Trisomy 10p

    Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] Some of the characteristics of Edward syndrome may include: defects of the kidneys, ureters, heart, lungs and diaphragm cleft lip or cleft palate small skull (microcephaly[betterhealth.vic.gov.au] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com]

  • Acrofacial Dysostosis Type Catania

    Radiologic features include delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and ovoid vertebral bodies.[mendelian.co] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] Small hand Disproportionately small hands 0200055 Smooth philtrum 0000319 30%-79% of people have these symptoms Abnormal hair pattern Abnormal distribution of hair 0010720[rarediseases.info.nih.gov]

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