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17 Possible Causes for Delayed Bone Age, Syndactyly, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    An autosomal recessive disorder characterized by intrauterine growth retardation, postnatal retardation, microcephaly, sparse hair, toe syndactyly, and characteristic facial[ncbi.nlm.nih.gov] Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    Syndactyly (fusion) of toes. Sprengel's neck deformity - unilateral shortening and webbing to trunk. X-ray abnormalities include: Delayed bone age.[patient.info] However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome

    Patient also had spina bifida, syndactyly, undescended testis and growth retardation.[joacp.org] bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    In the form of sclerosteosis (Truswell–Hansen disease) the patients are tall and fat with syndactyly and nail dysplasia. The hyperostosis is classically endosteal.[elsevier.es] Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature.[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com]

  • Ring Chromosome 10

    The patient was referred to our Unit because of persistent thrombocytopenia and syndactyly, pes planus and a bilateral Babinski sign.[omicsonline.org] Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome Type 2

    […] type 1 HOXD13 Syndactyly type 5 HOXD13 Syndactyly, mesoaxial synostotic, with phalangeal reduction BHLHA9 TANC2 related brain disorders TANC2 Tarp syndrome RBM10 Temple syndrome[centogene.com] bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    Cutis laxa has also been described in children with Lenz-Majewski hyperostotic dwarfism in association with syndactyly, brachydactyly, mental retardation, hypertelorism and[caribbean.scielo.org] Radiological investigation of the hand wrist bone showed a markedly delayed bone age.[karger.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Weaver Syndrome

    Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Downslanted palpebral fissures Downward slanting of the opening between the eyelids 0000494 Finger syndactyly[rarediseases.info.nih.gov] delay.[ncbi.nlm.nih.gov] Other features include cerebellar nystagmus, strabismus, pes planus, kyphoscoliosis, unequal lower limb length, syndactyly, large hands and feet, abnormal dermatoglyphics,[scielo.br]

  • Short Stature - Wormian Bones - Dextrocardia Syndrome

    […] treatment may take priority over syndactyly.[link.springer.com] bone age, facial dysmorphisms, and expressive language delays, indicative to a specific set of signs, symptoms or other health indicators, associated with short stature with[wellnessadvocate.com] Wide spacing between first and second toes ( Matthews and Robin, 2011 ). 3. Skin. a. Short neck with excess nuchal skin. C. Associated findings. 1. Prematurity. 2.[nursekey.com]

  • Acrofacial Dysostosis Type Catania

    Affiliated tissues include bone , and related phenotypes are pectus excavatum and finger syndactyly OMIM : 57 The Catania type of acrofacial dysostosis is characterized by[malacards.org] Radiologic features include delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and ovoid vertebral bodies.[mendelian.co] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com]

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