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17 Possible Causes for Delayed Bone Age, Wide Space Between the First and Second Toe

  • Dubowitz Syndrome

    Analysis of approximately 30 cases reveals prevalence of growth failure and delayed bone age, mild microcephaly, broad forehead with sparse frontal hair, telecanthus, blepharophimosis[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Skeletal issues can be delayed bone age, fifth finger clinodactyly , two/three toe syndactyly , and pes planus . Some are very prone to eczema or have severe allergies.[dubowitzsyndrome.net]

  • Russell-Silver Syndrome

    However, in each child with RSS, a particular attention should be given to a decreased height velocity, a severely delayed bone age as well as a history of major perinatal[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] bone age Low birth weight Short height, short arms, stubby fingers and toes Stomach and intestine problems such as acid reflux and constipation The condition is usually diagnosed[nlm.nih.gov]

  • Seckel Syndrome

    bone age, hip dysplasia, and elbow dislocation (Faivre et al. 2002).[preventiongenetics.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] age delay 2 6 9.[scielo.br]

  • Kenny-Caffey Syndrome Type 1

    Proportionate growth retardation (prenatal and postnatal) associated with delayed bone age is the most common feature.[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com] (see photos below) Delayed bone age Short or very short stature Low blood calcium High blood phosphorus Carious teeth Other dental abnormalities Normal intelligence in most[forgottendiseases.org]

  • Ring Chromosome 10

    Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] . _2 46, XY, upd(7), r(7)(p11.2q21) pat Russell-Silver syndrome, intrauterine growth retardation, feeding difficulties, retarded bone age, growth retardation, motor development[chr7.org]

  • Growth Delay due to Insulin-Like Growth Factor I Resistance

    Other features may include delayed bone age, developmental delay, and dysmorphic features.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Delayed puberty X-rays showing delayed bone development In adults, abnormally low levels of GH and/or IGF-1 may cause subtle, nonspecific symptoms such as: Decreased bone[labtestsonline.org]

  • Cutis Laxa

    Radiological investigation of the hand wrist bone showed a markedly delayed bone age.[karger.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] . 1 An advanced bone age is often considered a prerequisite for the diagnosis. 2 3 The disorder is dominantly transmitted with most cases being isolated instances within kindreds[jmg.bmj.com]

  • Weaver Syndrome

    delay.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The younger sibling did not present accelerated growth and experienced delayed bone maturation at the age of 13 months.[cags.org.ae]

  • Trisomy 10p

    Affected infants and children may also exhibit abnormally delayed, immature bone development (delayed bone age).[rarediseases.org] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com] Growth retardation Prematurity; gestational age 30 weeks Bone anchored hearing aid Periorbital hemangioma 46 F 12.9 46, XX, arr cgh 16p13.11p13.12 (14, 687, 636-16, 452,[ojrd.biomedcentral.com]

  • Nicolaides-Baraitser Syndrome

    Bone age can be variable: 16 children with delayed bone age and two with advanced bone age have been reported.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] bone age microcephaly coarse facial features, including wide nose, wide mouth, and thick eyebrows and lashes Causes [ edit ] Autosomal recessive inheritance is the most likely[en.wikipedia.org]

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