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400 Possible Causes for Delayed Closure of Fontanelles

  • Cleidocranial Dysplasia

    Cleidocranial dysplasia (CCD) is a rare genetic disorder of bone, characterised by hypoplastic/aplastic clavicles, delayed closure of fontanelles and sutures of the cranium[ncbi.nlm.nih.gov] We studied a Chinese family that included three affected individuals with CCD phenotypes; the clinical features of patients with CCD include delayed closure of fontanelles[ncbi.nlm.nih.gov] CCD is an autosomal skeletal disorder characterized by several features such as delayed closure of fontanels, dental abnormalities and hypoplastic clavicles.[ncbi.nlm.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    Clinical features include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective dentition, small eyes with hypermetropia[uniprot.org] OMIM : 57 Kenny-Caffey syndrome is characterized by severe proportionate short stature, cortical thickening and medullary stenosis of the tubular bones, delayed closure of[malacards.org] […] the anterior fontanel, eye abnormalities, and transient hypocalcemia.[malacards.org]

  • Autosomal Recessive Pachydermoperiostosis 

    Currarino's disease is an extremely rare variant of primary hypertrophic osteoarthropathy in which there is delayed closure of the fontanelles and an absence of skin involvement[ncbi.nlm.nih.gov] Autosomal recessive primary hypertrophic osteoarthropathy1 (PHOAR1) is characterized by delayed closure of the fontanels, digital clubbing, arthropathy and periostosis.[ncbi.nlm.nih.gov] We have now encountered three siblings, two of whom had digital clubbing, patent arterial ducts and delayed closure of the cranial fontanels.[ncbi.nlm.nih.gov]

  • Cranio-Osteo-Arthropathy

    closure of the cranial sutures and fontanels, resulting in wide fontanels, and an increased number of wormian bones.[orpha.net] They typically present earlier in childhood and have delayed neurocranial ossification, with delayed closure of the fontanelles, and may also have congenital heart disease[dvkeywords.blogspot.com] closure of the fontanels, periostosis, and variable patent ductus arteriosus.[genecards.org]

  • Vitamin D Deficiency

    […] dentition, delayed anterior fontanelle closure Investigations Infants Infants: Exclusively breastfed infants with at least one other risk factor without symptoms/signs -[rch.org.au] […] tooth eruption (no incisors by aged 10 months, no molars by age 18 months) - Craniotabes (softening of skull bones) - Delayed closure of anterior fontanelle - Frontal bossing[starship.org.nz] In older infants with rickets, sitting and crawling are delayed, as is fontanelle closure; there is bossing of the skull and costochondral thickening.[merckmanuals.com]

  • Pyknodysostosis

    closure of the fontanelles, and hypoplasia of the terminal phalanges.[medical-dictionary.thefreedictionary.com] Pyknodysostosis Description, Causes and Risk Factors: A condition characterized by short stature, delayed closure of the fontanels, and hypoplasia of the terminal phalanges[medigoo.com] closure of the fontanelles, and hypoplasia of the terminal phalanges; autosomal recessive inheritance.[medical-dictionary.thefreedictionary.com]

  • Russell-Silver Syndrome

    […] of the anterior fontanel (soft spot) · frequent ear infections or chronic fluid in ears · congenital absence of the second premolars · delay of gross and fine motor development[coltongeorge.com] […] stomach emptying resulting in vomiting or frequent spitting up slow movement of the small intestine &/or large intestine (constipation) late closure of the anterior fontanel[magicfoundation.org] […] resulting in vomiting or frequent spitting up c) slow movement of the small intestine &/or large intestine (constipation) · blue sclera (bluish tinge in white of eye) · late closure[coltongeorge.com]

  • Lenz-Majewski Syndrome

    Characterized by multiple congenital anomalies (delayed closure of fontanel, proximal symphalangism, prominent scalp cutaneous veins), mental retardation, and progressive[accessanesthesiology.mhmedical.com] Spanish displasia de Lenz - Majewski English Delayed closure of fontanel, proximal symphalangism, prominent cutaneous veins,mental retardation, and progressive skeletal sclerosis[mymemory.translated.net] The radiographic features of the LMHD skeleton include delayed closure of the anterior fontanel with progressive osteosclerosis of the skull, including the petrous bones and[docksci.com]

  • Saethre-Chotzen Syndrome

    closure of large fontanels, brachycephaly, acrocephaly, brachydactyly, cutaneous syndactyly, broad great toes, and mild shortness of stature.[ncbi.nlm.nih.gov] Abstract A family is described in which 15 persons in five generations are affected with a complex of skeletal malformations which variably includes peculiar asymmetric facies, delayed[ncbi.nlm.nih.gov]

  • Metabolic Syndrome

    We report on a consanguineous Lebanese family where two sibs had an axial hypotonia, developmental delay, hirsutism, large fontanels with delayed closure, and dysmorphic facial[ncbi.nlm.nih.gov]

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