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11 Possible Causes for Delayed Dentition, Dysmorphic Face, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org] […] fissures, Brushfield spots, small mouth, small ears, excessive skin at the nape of the neck, single transverse palmar crease, and short fifth finger with clinodactyly and wide[dx.doi.org]

  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , and delayed eruption of the permanent dentition.[ncbi.nlm.nih.gov] face (bird-like), and mild to severe intellectual disability.[orpha.net]

  • Kenny-Caffey Syndrome Type 1

    space between the first and second toes.[medcraveonline.com] Clinical features include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective dentition, small eyes with hypermetropia[uniprot.org] The association of severe short stature, dysmorphic face, teeth abnormalities and bone dysplasia must guide us to suggest the diagnosis especially in the Middle Eastern and[abstracts.eurospe.org]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] dentition, and hypomyelination, see Pol III-related leukodystrophy ataxia, fatal X-linked, with deafness and loss of vision, see Arts syndrome ataxia-deafness-optic atrophy[mygenomics.com] Dysmorphism (Greek Morpheus, God of Sleep who may take any human “form” in dreams) is applied to a “bad form” of body part, often the facies (Latin) or “face” that can distinguish[musculoskeletalkey.com]

  • Craniofrontonasal Dysplasia

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] until the age of 5-8 years old, after permanent dentition. [8] A bifid nose tip is only treated at the age of 18 years, when the patient's skeleton has fully matured. [8][mjdrdypu.org] Head radiographs showed macrocephaly and brachycephaly with dysmorphic face. Rest infantogram was normal.[ruralneuropractice.com]

  • Cutis Laxa

    Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Early development was normal, except language and dentition delayed. There was no family history.[panafrican-med-journal.com] Cutis laxa with face dysmorphism,cleft palate & MR: folds ] 20. Cutis laxa with face dysmorphism,cleft palate & MR: folds ] 21.[slideshare.net]

  • Baraitser Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] acrodermatitis enteropathica, hyperpigmentation of the skin, very low insulin-like growth factor I levels with delayed bone age, relative hypolipidemia, initial camptodactyly[ncbi.nlm.nih.gov] Figure 1: The proband aged 7, with a dysmorphic face: Large forehead, high arched eyebrows, broad nasal bridge, long philtrum, strabismus, epicanthus, thin lips and short[pediatricneurosciences.com]

  • Nicolaides-Baraitser Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Delayed tooth eruption is common, often requiring surgical extraction of primary dentition to allow secondary dentition to migrate into place.[ncbi.nlm.nih.gov] (round and flat face, facial asymmetry with right/left hemi-hypoplasia, dolichocephaly, telecanthus, thick eyebrows, mild synophrys, short nose, hypertelorism, long philtrum[bredagenetics.com]

  • Short Stature - Wormian Bones - Dextrocardia Syndrome

    Wide spacing between first and second toes ( Matthews and Robin, 2011 ). 3. Skin. a. Short neck with excess nuchal skin. C. Associated findings. 1. Prematurity. 2.[nursekey.com] Delayed and/or abnormal dentition is often associated.[rrnursingschool.biz] Short stature dysmorphic face pelvic scapula dysplasia[?] Short stature heart defect craniofacial anomalies[?] Short stature hyperkaliemia acidosis[?][encyclopedia.kids.net.au]

  • Acrofacial Dysostosis Type Catania

    He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] […] speech and language development Hyperactivity Gastroesophageal reflux Thickened skin Hoarse voice Abnormality of the dentition Polydactyly Anal atresia Short palm Postaxial[mendelian.co] Scrotum-Joint Laxity Syndrome Flat Face-Microstomia-Ear Anomaly Syndrome Holoprosencephaly Hypoglossia-Hypodactyly Syndrome Intellectual Disability-Short Stature-Hypertelorism[familydiagnosis.com]