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13 Possible Causes for Delayed Dentition, Mental Retardation, Wide Space Between the First and Second Toe

  • Down Syndrome

    Abstract Although there is considerable variability, most individuals with Down syndrome have mental retardation and speech and language deficits, particularly in language[oadoi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

  • Seckel Syndrome

    , and delayed eruption of the permanent dentition.[ncbi.nlm.nih.gov] It is extremely rare and typically causes dwarfism, mental retardation, intrauterine growth retardation and microcephaly.[symptoma.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    space between the first and second toes.[medcraveonline.com] Clinical features include cortical thickening and medullary stenosis of the tubular bones, delayed closure of fontanels, defective dentition, small eyes with hypermetropia[uniprot.org] Mental retardation of varying degree was found in all patients. All had severe intrauterine and postnatal growth retardation. Four patients have died.[scienceopen.com]

  • Cutis Laxa

    Early development was normal, except language and dentition delayed. There was no family history.[panafrican-med-journal.com] While the patients with GORAB mutations have severe osteopenia, the patients with PYCR1 mutations have severe mental retardation.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] dentition, and hypomyelination, see Pol III-related leukodystrophy ataxia, fatal X-linked, with deafness and loss of vision, see Arts syndrome ataxia-deafness-optic atrophy[mygenomics.com] Retardation, Characteristic Facies, Short Stature, and Skeletal Anomalies KBGS 148050 Genetic Test Registry Kniest Dysplasia 156550 Genetic Test Registry Larsen Syndrome[ukgtn.nhs.uk]

  • Craniofrontonasal Dysplasia

    […] until the age of 5-8 years old, after permanent dentition. [8] A bifid nose tip is only treated at the age of 18 years, when the patient's skeleton has fully matured. [8][mjdrdypu.org] […] deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Joint hyperflexibility Joints move beyond expected range of motion 0005692[rarediseases.info.nih.gov] retardation.[link.springer.com]

  • Nicolaides-Baraitser Syndrome

    Delayed tooth eruption is common, often requiring surgical extraction of primary dentition to allow secondary dentition to migrate into place.[ncbi.nlm.nih.gov] […] deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Joint dislocation Joint dislocations Recurrent joint dislocations [ more[rarediseases.info.nih.gov] Dental eruption is delayed inonethird of cases, which may involveprimary dentition, but more frequentlyinvolved secondary dentition.[docslide.com.br]

  • Acrofacial Dysostosis Type Catania

    He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] […] speech and language development Hyperactivity Gastroesophageal reflux Thickened skin Hoarse voice Abnormality of the dentition Polydactyly Anal atresia Short palm Postaxial[mendelian.co] [Am J Med Genet 47:660-678] described a new AFD with mental retardation in a Sicilian mother and her four sons characterized by intrauterine growth retardation (IUGR), postnatal[semanticscholar.org]

  • Baraitser Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] acrodermatitis enteropathica, hyperpigmentation of the skin, very low insulin-like growth factor I levels with delayed bone age, relative hypolipidemia, initial camptodactyly[ncbi.nlm.nih.gov] Abstract We describe the case of a boy with moderate mental retardation associated with tall stature, obesity, macrocephaly and typical facial features, characterized by a[ncbi.nlm.nih.gov]

  • Adactyly of Foot

    Eczema Delayed eruption of teeth Abnormality of skin pigmentation Dry skin Malabsorption Telecanthus Recurrent infections Thrombocytopenia Neoplasm Vesicoureteral reflux[mendelian.co] Journal of Medical Genetics 38(6): 405-409, 2001 Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3[eurekamag.com] Synonyms:Anterior Polydactyly Replaces: Anterior Duplication of the Limb, Tibial Polydactyly Foot, Preaxial Polydactyly of Subjective: A widely spaced gap between the first[quizlet.com]

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