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1,626 Possible Causes for Delayed Development of Motor Skills, Dysmorphic Face, Wide Space Between the First and Second Toe

  • Down Syndrome

    Poor oral motor control may impact the development of language skills.[dseinternational.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

  • Russell-Silver Syndrome

    motor skills and early puberty 55.[doi.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] and further dysmorphisms.[ncbi.nlm.nih.gov]

  • Congenital Muscular Dystrophy

    These changes in the structure of the brain lead to significantly delayed development of speech and motor skills and moderate to severe intellectual disability.[ghr.nlm.nih.gov] In some of the patients, facial dysmorphism was also reported: the forehead was high and prominent with a wide fontanel, the mid-face was flat, and the nose and filtrum short[doi.org] Other common features include hydrocephalus and dysmorphic face (short nasal bridge, micrognathia, and midface hypoplasia) 184.[doi.org]

    Missing: Wide Space Between the First and Second Toe
  • Mucopolysaccharidosis

    During the first stage, early mental and motor skill development may be somewhat delayed.[en.wikipedia.org]

    Missing: Wide Space Between the First and Second Toe
  • SHORT Syndrome

    They can take time to develop after the child acquires gross motor skills.[medicalnewstoday.com] We report the two-year-four-month old female with SHORT syndrome who present growth retardation and dysmorphic features (triangular-shaped face, prominent forehead, ocular[ncbi.nlm.nih.gov] Fig. 1 Dysmorphic features (triangular-shaped face with prominent forehead and deeply-set eyes) Fig. 2 Dysmorphic features and body silhouette - front view Fig. 3 Lipodystrophy[ijponline.biomedcentral.com]

    Missing: Wide Space Between the First and Second Toe
  • Prader-Willi Syndrome

    In addition, children with PWS might experience speech and sleep disorders, as well as scoliosis and delayed motor skill development.[penfieldbuildingblocks.org] Motor and language development are significantly delayed, and there are difficulties with gross motor skills, coordination and balance, voice problems (primarily hypernasality[web.archive.org] Delayed motor skills: Children might reach the common milestones of progress in learning coordination skills, such as sitting up or walking, later than usual.[medicalnewstoday.com]

    Missing: Wide Space Between the First and Second Toe
  • Mucopolysaccharidosis 3

    Summary Epidemiology The disorder is underdiagnosed (due to the generally very mild dysmorphism); it is the most frequent MPS in the Netherlands and Australia with respective prevalences of 1/53 0000 and 1/67 000. The frequency of the different subtypes varies between countries: subtype A is more frequent in[…][orpha.net]

    Missing: Wide Space Between the First and Second Toe
  • Trisomy X Syndrome

    […] speech, deficient language skills, and delayed development of motor skills.[susans.org] development of motor skills such as language and speech Learning difficulties like dyslexia Proportionately smaller head size or microcephaly Introvert Enamel Hypoplasia[syndromespedia.com] […] speech and language development, and difficulty reading Delayed motor skills, such as sitting and walking Problems processing sound Behavioral and emotional problems, including[everydayhealth.com]

    Missing: Wide Space Between the First and Second Toe
  • Klinefelter Syndrome

    Children with Klinefelter syndrome may have low muscle tone (hypotonia) and problems with coordination that may delay the development of motor skills, such as sitting, standing[ghr.nlm.nih.gov] Affected boys often have learning disabilities, resulting in mild delays in speech and language development and problems with reading.[ghr.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] face (bird-like), and mild to severe intellectual disability.[orpha.net] A dysmorphic face with a receding chin and a relatively big nose could also render mask ventilation difficult. [11] Dental malocclusion, receding chin, high palatal arch could[joacp.org]

    Missing: Delayed Development of Motor Skills