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4,079 Possible Causes for Delayed Development of Motor Skills, Short Stature, Wide Space Between the First and Second Toe

  • Down Syndrome

    stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called[merriam-webster.com] Poor oral motor control may impact the development of language skills.[dseinternational.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Russell-Silver Syndrome

    Abstract A family is described with a syndrome of short stature, abnormal pigmentation of the skin and mild facial dysmorphism.[ncbi.nlm.nih.gov] motor skills and early puberty 55.[doi.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    More than 200 inherited skeletal dysplasias are currently recognised.[socialstyrelsen.se] As a result of their orthopedic abnormalities, they also have delayed development of motor skills such as standing and walking.[ghr.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Mucopolysaccharidosis

    The pathogenesis and treatment of systemic skeletal dysplasia in MPS IVA remains an unmet challenge.[ncbi.nlm.nih.gov] During the first stage, early mental and motor skill development may be somewhat delayed.[en.wikipedia.org] Mucopolysaccharidosis type IVB (MPS IVB) is a very rare lysosomal storage disorder characterized by skeletal dysplasia, hearing disorder, and cardiac valvular disease.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • MELAS Syndrome

    stature.[ncbi.nlm.nih.gov] Early development is usually normal except for short stature.[pediatricneurologybriefs.com] stature, vomiting, headache, cortical blindness, deafness and dementia.[e-arm.org]

    Missing: Wide Space Between the First and Second Toe
  • Mowat-Wilson Syndrome

    Patients can show a variety of other anomalies like short stature, microcephaly, Hirschsprung disease, malformations of the brain, seizures, congenital heart defects and urogenital[ncbi.nlm.nih.gov] development and motor skills.[medicinenet.com] stature, and genitourinary anomalies.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • SHORT Syndrome

    Hyperphagic short stature is associated with learning disabilities.[patient.info] They can take time to develop after the child acquires gross motor skills.[medicalnewstoday.com] Gross motor skills like crawling and walking can be slow to mature and fine motor skills may take time to develop.[medicinenet.com]

    Missing: Wide Space Between the First and Second Toe
  • Prader-Willi Syndrome

    Clinical manifestations include mental retardation; muscular hypotonia; hyperphagia; obesity; short stature; hypogonadism; strabismus; and hypersomnolence.[icd9data.com] In addition, children with PWS might experience speech and sleep disorders, as well as scoliosis and delayed motor skill development.[penfieldbuildingblocks.org] Motor and language development are significantly delayed, and there are difficulties with gross motor skills, coordination and balance, voice problems (primarily hypernasality[web.archive.org]

    Missing: Wide Space Between the First and Second Toe
  • Fucosidosis

    At age 12, he could not walk without help; he was admitted to the hospital with intellectual disability, short stature and coarse facial features.[ncbi.nlm.nih.gov] People with this condition often have delayed development of motor skills such as walking; the skills they do acquire deteriorate over time.[ghr.nlm.nih.gov] The clinical examination revealed short stature, coarse facial features, bilateral ptosis, hypertonic lower extremities, psychomotor retardation and asthma.[omicsonline.org]

    Missing: Wide Space Between the First and Second Toe
  • Ataxia Telangiectasia

    A 9-year-old girl born to healthy parents showed manifestations suggestive of ataxia telangiectasia (AT), such as short stature, sudden short bouts of horizontal and rotary[ncbi.nlm.nih.gov] The first signs of the disease, which include delayed development of motor skills, poor balance, and slurred speech, usually occur during the first decade of life.[secure.ssa.gov] stature and delayed puberty) Increased risk to develop leukemia and lymphoma and rarely other cancers The physical features associated with AT can vary in severity among[chop.edu]

    Missing: Wide Space Between the First and Second Toe

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