Delayed Female Puberty: Causes & Reasons

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Possible Causes for Delayed Female Puberty

Kallmann Syndrome

Systemic: Delayed female puberty and secondary sexual characteristics are the chief complaints in Kallmann syndrome. [symptoma.com]

Delayed Puberty Failure of onset of puberty is the clinical sign that occurs in both males and females with the condition. [news-medical.net]

Kallmann syndrome and the related condition, congenital hypogonadotropic hypogonadism (CHH), are rare causes of delayed or absent puberty in both males and females. [delayed-puberty.com]

Hypogonadotropic Hypogonadism

HH is not to be confounded with delayed male puberty or delayed female puberty due to physiological variance, nutrient deficiencies, overweight/obesity or systemic diseases [symptoma.com]

We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty. [ncbi.nlm.nih.gov]

Possible Complications Delayed puberty Early menopause (in females) Infertility Low bone density and fractures later in life Low self-esteem due to late start of puberty [nicklauschildrens.org]

Anterior Pituitary Hypofunction

puberty - adult females have Secondary Amenorrhea; produces osteoporosis, hot flashes (lack of Estrogen), decreased libido - males have impotence, due to decreased libido [quizlet.com]

Too much prolactin can cause a delay in puberty, a disruption of normal periods in females, and a milky discharge from the nipples. [chw.org]

[…] of Pituitary TROPHIC HORMONE DEFICIENCIES (1&2)) Clinical and laboratory findings of Pituitary TROPHIC HORMONE DEFICIENCIES: 1) GONADOTROPINS (FSH & LH): - children have delayed [quizlet.com]

Prader-Willi Syndrome

In PWS, puberty is usually delayed and fails to complete, with most females never having regular menstrual cycles. [ncbi.nlm.nih.gov]

Both males and females have underdeveloped genitals. Puberty is delayed or incomplete, and most are infertile. What is Prader-Willi syndrome? [medicinenet.com]

We report a female patient with uniparental disomy, who experienced precocious puberty with menarche at age 8 years. [ncbi.nlm.nih.gov]

Ovarian Dysgenesis

[…] at birth and presents with delayed puberty and primary amenorrhea. [jpgo.org]

However, affected individuals present during adolescence or young adulthood with either delayed or absent puberty resulting in primary or sometimes secondary amenorrhea. [orpha.net]

She also had delayed puberty and absence of breast development. [omicsonline.org]

Prolactinoma

The most common symptoms of a prolactinoma in children and adolescents result from elevated prolactin and include delayed puberty in males and females, amenorrhea and galactorrhea [clinicaladvisor.com]

Such alterations appear in adolescent females as delayed puberty (48% in our experience), primary amenorrhea (14–41%), secondary amenorrhea (29–45%) and oligomenorrhea (up [karger.com]

Diabetes Mellitus

[…] type 1, despite modern treatment, also delayed puberty and menarche, menstrual irregularities (especially oligomenorrhoea), mild hyperandrogenism, polycystic ovarian syndrome [en.wikipedia.org]

In the developed world is the most common cause of non-traumatic adult amputation, usually of toes and or feet.[16] Female infertility is more common in women with diabetes [en.wikipedia.org]

Richards-Rundle Syndrome

As in our patient, the time of the clinical diagnosis of AAHH in most cases took place after the apparition of a secondary amenorrhea or a delayed puberty in a deaf female [bjmg.edu.mk]

Growth Hormone Deficiency

Left untreated, growth hormone deficiency may lead to short stature and delayed puberty. [nlm.nih.gov]

[…] hormone deficiency can occur with deficiencies of other hormones such as those that control: Production of thyroid hormones Water balance in the body Production of male and female [nlm.nih.gov]

Panhypopituitarism

lactation failure following delivery Males: asymptomatic FSH/LH deficiency Females: primary amenorrhea (delayed puberty), secondary amenorrhea, irregular menstrual cycles [amboss.com]

Left untreated, growth hormone deficiency may lead to short stature and delayed puberty. [mountsinai.org]

During childhood: dwarfism (see short stature) During adulthood: usually asymptomatic; subtle findings include weight gain, weakness, and depression Prolactin deficiency Females [amboss.com]

Turner Syndrome

[…] growth Abnormal puberty: Girls with Turner syndrome do not have ovaries but do have normal female external sex organs. [hopkinsmedicine.org]

Common ones are short height, absent or delayed puberty, and infertility. Causes Turner syndrome happens in girls and women. Females have two X chromosomes. [cancercarewny.com]

A standard 30-cell karyotyping analysis should be ordered in any female with primary amenorrhea, unexplained growth failure or delay in the onset of puberty, absent uterus [clinicaladvisor.com]

Craniopharyngioma

puberty - children irregular periods or loss of normal menstrual function (Amenorrhoea) - adult females impotence - adult males reduced fertility - adults decrease in sex [pituitary.org.uk]

[…] disturbed sleep patterns vision disturbance behavioural changes, including introversion and inability to concentrate slow growth increased sensitivity to cold or heat early or delayed [pituitary.org.uk]

Juvenile Myxedema

Children with juvenile hypothyroidism may present with precocious puberty. [flexikon.doccheck.com]

Reproductive system: females present with menstrual irregularities, infertility and anovulation. Males may present with gonadal dysfunctions. [flexikon.doccheck.com]

Musculoskeletal system: muscle stiffness, weakness, cramps, mialgias, arthralgias, joint stiffness and effusions, Carpal Tunnel syndrome and delayed linear bone growth in [flexikon.doccheck.com]

Sickle Cell Anemia

This is likely because of the delay in puberty (sexual maturation), priapism, and primary gonad dysfunction. [oncofertility.northwestern.edu]

but more often in males than in females. [oncofertility.northwestern.edu]

[…] deformability of sickled cells Bone marrow stem cell transplant Pain management with narcotics Effect on Fertility Sickle cell disease effects fertility in both males and females [oncofertility.northwestern.edu]

Chronic Kidney Insufficiency

Chronic kidney insufficiency affects a significant number of individuals in the developed countries, particularly the United States. The progressive nature of the disease and a substantial reduction in the quality of life over the period of time are the primary reasons why an early diagnosis is crucial. Anemia,[…] [symptoma.com]

Juvenile Idiopathic Arthritis

Juvenile rheumatoid arthritis, also termed as juvenile idiopathic arthritis sometimes, is not uncommon in children. Pain in the joint, stiff joints, and swelling are some of the common presenting complaints. Constant pain is the major and most bothering symptom. The causes for the pain vary and depend on many[…] [symptoma.com]

Hydrocephalus

Hydrocephalus Other names Water on the brain[1] Hydrocephalus as seen on a CT scan of the brain. The black areas in the middle of the brain (the lateral ventricles) are abnormally large and filled with fluid. Pronunciation [2] Specialty Neurosurgery Symptoms Babies: rapid head growth, vomiting, sleepiness,[…] [en.wikipedia.org]

Cystic Fibrosis

Cystic fibrosis (mucoviscidosis) is an autosomal recessive genetic disorder of the exocrine glands. It is characterized by the production of abnormally viscous mucus by the affected glands. Cystic fibrosis is usually recognized in infancy or early childhood. The clinical manifestations of cystic fibrosis are typically[…] [symptoma.com]

Malabsorption Syndrome

A case of beta galactosidase deficiency is described in a 20-month-old boy. The child was hospitalized at 4 months of age for malabsorption syndrome. Biopsies of the small intestine and liver were performed and electron microscopy of the liver specimens strongly suggested a gangliosidosis. The cytoplasm of[…] [ncbi.nlm.nih.gov]

Mucopolysaccharidosis

Abstract Mucopolysaccharidosis Type II (Hunter syndrome) is a rare X-linked recessive storage disorder caused by deficiency of lysosomal enzyme iduronate-2-sulfatase, causing excess accumulation of glycosaminoglycans in the lysosomes resulting in cellular damage, organ failure and death. Severe subtype develops[…] [ncbi.nlm.nih.gov]

Thalassemia

History and Physical Examination Patients with the beta thalassemia trait generally have no unusual physical findings. In patients with beta thalassemia major, the physical findings are related to severe anemia, ineffective erythropoiesis, extramedullary hematopoiesis, and iron overload resulting from transfusion and[…] [emedicine.medscape.com]

Rothmund-Thomson Syndrome

Rothmund-Thomson syndrome is a rare autosomal recessive syndrome characterised by poikiloderma of the face and extremities, alopecia, short stature, and skeletal defects. We report a patient with the characteristic features of Rothmund-Thomson syndrome who also had lymphocyte chromosome abnormalities. She has[…] [ncbi.nlm.nih.gov]

Myxedema

Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness. Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis. It can also occur in patients who had thyroidectomy or[…] [emedicine.com]

Acromegaly

History Gigantism The presentation of patients with gigantism is usually dramatic, unlike the insidious onset of acromegaly in adults. Reasons for this difference include the close monitoring of growth in children and their relatively responsive growth-plate cartilage. Children with gigantism have few soft tissue[…] [emedicine.medscape.com]

Mucopolysaccharidosis Type 6

Summary Epidemiology Birth prevalence is between 1 in 43,261 and 1 in 1,505,160 live births. Clinical description The disorder shows a wide spectrum of symptoms from slowly to rapidly progressing forms. The characteristic skeletal dysplasia includes short stature, dysostosis multiplex and degenerative joint disease.[…] [orpha.net]

Renal Osteodystrophy

J Nephrol. 2016 Oct;29(5):617-26. doi: 10.1007/s40620-016-0339-9. Epub 2016 Jul 29. Carvalho C 1, 2, 3, 4, Alves CM 1, 2, 3, Frazão JM 5, 6, 7, 8. Author information 1 Instituto de Investigação E Inovação em Saúde, Universidade do Porto, Porto, Portugal. 2 INEB, Instituto Nacional de Engenharia Biomédica, Universidade do[…] [ncbi.nlm.nih.gov]

Chronic Disease

Delayed Male Puberty

Female delayed puberty. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115697/Female-delayed-puberty. Updated January 9, 2018. [winchesterhospital.org]

This condition can be caused by: Constitutional delay Some children simply take longer than their peers; they will catch up at some point This is the most common cause of delayed [wmhs.com]

[…] hormone estrogen, causing a delay in puberty for boys. [nydailynews.com]

Hypogonadotropic Hypogonadism Type 16

Possible Complications Health problems that may result from HH include: Delayed puberty Early menopause (in females) Infertility Low bone density and fractures later in life [pennmedicine.org]

If the condition begins after puberty or in adulthood, symptoms will often improve with treatment. [pennmedicine.org]

Luteinizing Hormone Deficiency

Treatment for hypogonadism Estrogen is given to females with delayed puberty, which helps in developing secondary sexual traits like breast, pubic hair, and body shape. [healthhype.com]

If there is delay of puberty in female, synthetic estrogen is given to the girl for development of secondary sexual characteristic such as pubic hair, enlargement of breast [tandurust.com]

LH deficiency can manifest in females or males as delayed puberty, hypogonadism at any age, or reproductive abnormalities that can be dramatic or subtle. [thehealthscience.com]