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72 Possible Causes for Delayed Female Puberty, Midline Defects

  • Panhypopituitarism

    CONCLUSION: These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[ncbi.nlm.nih.gov] Left untreated, growth hormone deficiency may lead to short stature and delayed puberty.[mountsinai.org] We report on a neonate with unexplained heart failure and minor physical anomalies, suggesting a midline defect. She was diagnosed with complete CPHD.[ncbi.nlm.nih.gov]

  • Kallmann Syndrome

    Abstract Kallmann syndrome (isolated hypogonadotropic hypogonadism) is associated with a number of midline defects, especially anosmia.[doi.org] Systemic: Delayed female puberty and secondary sexual characteristics are the chief complaints in Kallmann syndrome.[symptoma.com] MR images of midline defects in Kallmann syndrome were rarely seen in the literature.[jofem.org]

  • Growth Hormone Deficiency

    Neonates who have congenital defects of the pituitary or hypothalamus may have hypoglycemia (which also can occur in older children), midline defects (eg, cleft palate), or[msdmanuals.com] Left untreated, growth hormone deficiency may lead to short stature and delayed puberty.[medlineplus.gov] Congenital GHD results from genetic error, and may be associated with brain structure defects or with midline facial defects such as a cleft palate or single central incisor[rarediseases.org]

  • Hypogonadotropic Hypogonadism

    […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[medical-dictionary.thefreedictionary.com] HH is not to be confounded with delayed male puberty or delayed female puberty due to physiological variance, nutrient deficiencies, overweight/obesity or systemic diseases[symptoma.com] We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty.[ncbi.nlm.nih.gov]

  • Anterior Pituitary Hypofunction

    It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects.[icd10data.com] puberty - adult females have Secondary Amenorrhea; produces osteoporosis, hot flashes (lack of Estrogen), decreased libido - males have impotence, due to decreased libido[quizlet.com] Too much prolactin can cause a delay in puberty, a disruption of normal periods in females, and a milky discharge from the nipples.[chw.org]

  • Hypogonadism

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[msdmanuals.com] Health problems that may result from HH include: Delayed puberty Early menopause (in females) Infertility Low bone density and fractures later in life Low self-esteem due[medlineplus.gov] Possible Complications Delayed puberty Early menopause (in females) Infertility Low bone density and fractures later in life Low self-esteem due to late start of puberty ([nicklauschildrens.org]

  • Scoliosis

    Abstract Cantrell's pentalogy (CP) is a rare syndrome characterized by defects in the lower sternum with ectopia cordis, anterior diaphragm defects, midline supraumbilical[ncbi.nlm.nih.gov] PubMed Google Scholar Burwell RG, Dangerfield PH: The NOTOM hypothesis for idiopathic scoliosis: is it nullified by the delayed puberty of female rhythmic gymnasts and ballet[doi.org] The NOTOM hypothesis for idiopathic scoliosis: is it nullified by the delayed puberty of female rhythmic gymnasts and ballet dancers with scoliosis?[doi.org]

  • Luteinizing Hormone Deficiency

    There was no anosmia, midline defects or gynaecomastia. He had scanty pubic hair which came only after testosterone injection (Tanner stage 2) but no axillary hair.[endocrine-abstracts.org] If there is delay of puberty in female, synthetic estrogen is given to the girl for development of secondary sexual characteristic such as pubic hair, enlargement of breast[tandurust.com] It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects.[icd10data.com]

  • Hypogonadotropic Hypogonadism 3

    Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects cleft lip and palate renal agenesis sensorineural[radiopaedia.org] See also [ edit ] Hypogonadism Hypogonadotropic hypogonadism Hypergonadotropic hypergonadism Delayed puberty and infertility Hypothalamus, pituitary gland, and HPG axis Gonads[en.wikipedia.org] […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[medical-dictionary.thefreedictionary.com]

  • Hypogonadotropic Hypogonadism 8

    Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects cleft lip and palate renal agenesis sensorineural[radiopaedia.org] E29.8 Other testicular dysfunction E29.9 Testicular dysfunction, unspecified E30 Disorders of puberty, not elsewhere classified E30.0 Delayed puberty Constitutional delay[apps.who.int] […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[medical-dictionary.thefreedictionary.com]

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