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436 Possible Causes for Delayed Myelination

  • Vitamin B12 Deficiency

    The underlying mechanisms may involve delayed myelination or demyelination of nerves; alteration in the S-adenosylmethionine:S-adenosylhomocysteine ratio; imbalance of neurotrophic[ncbi.nlm.nih.gov] MRI revealed cerebral atrophy and delayed myelination.[ncbi.nlm.nih.gov] The Brain CT revealed a cerebral atrophy and delayed myelination. Vitamin B12 supply was effective on anaemia and psychomotor delay.[ncbi.nlm.nih.gov]

  • Allan-Herndon-Dudley Syndrome

    In most of the cases reported so far, brain magnetic resonance imaging showed delayed myelination of the central white matter and this finding greatly affects the diagnosis[ncbi.nlm.nih.gov] We report a patient with Allan-Herndon-Dudley syndrome characterized by developmental delay, hypotonia, and delayed myelination caused by a novel SLC16A2 mutation (p.L291R[ncbi.nlm.nih.gov] Myelination delay and Allan-Herndon-Dudley syndrome caused by a novel mutation in the SLC16A2 gene. La Piana R. , Vanasse M. , Brais B. , Bernard G.[uniprot.org]

  • Hyperuricemia

    At the age of 23 years MR imaging revealed globally delayed myelination with relative sparing of the corpus callosum and frontal lobes.[ncbi.nlm.nih.gov]

  • Psychomotor Retardation

    Whole exome sequencing (WES) was performed in siblings with severely delayed myelination and psychomotor retardation.[ncbi.nlm.nih.gov] […] tendon reflexes and delayed myelination) from birth, associated with hypermethioninaemia and elevated serum creatine kinase levels.[orpha.net] Sequential cerebral MRI at age one and two year(s) respectively revealed frontal accentuated brain atrophy and significantly delayed myelination.[ncbi.nlm.nih.gov]

  • West Syndrome

    This patient is considered to have had an unusual variant of West syndrome associated with focal delayed myelination.[ncbi.nlm.nih.gov] MRI revealed cerebral atrophy and delayed myelination.[ncbi.nlm.nih.gov] myelination as a key factor underlying abnormal findings on DTI.[ncbi.nlm.nih.gov]

  • Hypomyelination - Congenital Cataract Syndrome

    We report two affected siblings with congenital cataracts, congenital heart defects, prenatal onset ventriculomegaly, progressive microcephaly, severely delayed myelination[ashg.org] Delayed myelinationDelayed myelination is a non specific finding associated with global developmental delay.[slideshare.net] Brain imaging shows cerebral atrophy and delayed myelination (summary by Schoch et al., 2017 ).[mendelian.co]

  • Entrapment Neuropathy

    In the other case, the lesion seemed to be a mild injury to the myelin sheath.[ncbi.nlm.nih.gov] Delayed segmental conduction velocity and partial conduction block were found at the midarm level.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spastic Paraplegia Type 56

    delayed myelination.[nature.com] New compound mutations in SPG56 gene – causing complicated HSP with delayed myelination.[hspersunite.org.au] As a rare clinical feature, delayed myelination has previously been reported in only two patients with CYP2U1 mutations.[nature.com]

  • Aspartylglucosaminuria

    Thus aspartylglucosaminuria is primarily a gray-matter disease also affecting white matter by delaying myelination.[ncbi.nlm.nih.gov] This is consistent with previous magnetic resonance imaging findings in the brains of aspartylglucosaminuria patients, revealing delayed myelination in childhood.[ncbi.nlm.nih.gov] On MRI, there may be poor differentiation between the gray and white matter, as well as evidence of delayed myelination.[ismrd.org]

  • Microcephalic Primordial Dwarfism due to ZNF335 Deficiency

    ., Principles of Neurology, 6th ed, p54) Delayed myelination MedGen UID: 224820 • Concept ID: C1277241 • Finding Delayed myelination.[ncbi.nlm.nih.gov] […] lesions Abnormality of metabolism/homeostasis Sensorineural hearing impairment Poor speech Ataxia CSF lymphocytic pleiocytosis Death in childhood Hemiplegia Poor head control Delayed[mendelian.co] Cerebellar atrophy Hypertonia Encephalopathy Myoclonus Clonus Rare Symptoms - Less than 30% cases Muscle weakness Skeletal muscle atrophy Poor suck Delayed myelination Brain[mendelian.co]

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