Delayed Onset of Puberty: Causes & Reasons

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Possible Causes for Delayed Onset of Puberty

Delayed Male Puberty

Klinefelter’s syndrome may present with a lack of pubertal progress rather than delayed onset. [journals.lww.com]

Being overweight or obese increases the likelihood that a girl will enter puberty earlier than average. Obesity may delay the onset of puberty in boys. [livestrong.com]

Delayed puberty Delayed puberty is the late onset of puberty. [medicinenet.com]

Familial Short Stature

However, they have delayed onset of puberty, and consequently, their pubertal growth spurt gets delayed; hence the name " late bloomers ". [childhealth-explanation.com]

[…] of puberty Absence of physical or psychological disease Constitutional Short Stature: Delayed growth in one parent but average final stature Normal birth history and growth [learn.pediatrics.ubc.ca]

A delay in the reactivation of the hypothalamic-pituitary pulse generator results in a later onset of puberty. [en.wikipedia.org]

Delayed Menarche

Late bloomers have delayed onset of puberty. [childhealth-explanation.com]

About one third of girls who present with delayed onset of puberty are at the extreme end of the normal spectrum of pubertal timing, or have constitutional delay. [clinicaladvisor.com]

[…] of diabetes Delayed menarche Diabetic nephropathy Diabetic retinopathy Puberty Type 1 diabetes STAGE RENAL-DISEASE METABOLIC-CONTROL NATURAL-HISTORY NEPHROPATHY MELLITUS [helda.helsinki.fi]

X-Linked Hypogonadotropic Hypogonadism without Anosmia

In its most severe form, nXHH presents as a complete absence of puberty, but delayed puberty or post-pubertal symptom onset may also occur. [symptoma.com]

Isolated Growth Hormone Deficiency Type 3

Woodhouse-Sakati Syndrome

Our aim was to study the clinical and genetic characteristics of the extended family of a 16-year-old female who presented with new-onset DM and had delayed puberty on physical [ncbi.nlm.nih.gov]

Kallmann Syndrome

• The diagnosis may be suggested by the observation of micropenis or cryptorchidism in infancy, or delayed onset of puberty at a later stage. • Affected individuals have [medlink.com]

• The diagnosis may be suggested by the observation of micropenis or cryptorchidism in infancy, or delayed onset of puberty at a later stage; for this reason, diagnosis [medlink.com]

A decrease in these hormones cause delayed onset of puberty, small non-functional gonads leading to decreased levels of sex hormones, lack of secondary sexual characters, [symptoma.com]

Boucher-Neuhäuser Syndrome

(cerebellar ataxia in 38 %; vision loss in 36 %; delayed puberty in 26 %). [zora.uzh.ch]

puberty=26[percnt]) at disease onset. [n.neurology.org]

[…] our review of the literature propose that the clinical presentation of BNS can be variable regarding both the age (ranging from 1 to 40 years) and the clinical symptoms at onset [zora.uzh.ch]

Froehlich Syndrome

The more obvious and frequently encountered characteristics include delayed onset of puberty, short stature, small testes, and obesity. [rarediseases.org]

Resolution depends on the response of the individual to treatment In some children, an onset of puberty (which may be delayed), marks the start of a normal development Information [dovemed.com]

Obesity with prepubertal onset mainly affects the breasts, abdomen, hips, and thighs. Puberty and the development of secondary sexual characteristics are delayed. [accesspediatrics.mhmedical.com]

Aqueduct of Sylvius Anomaly

onset of puberty. [ijri.org]

[…] present with endocrine disorder due to distraction of hypothalamus and pituitary stalk by a grossly dilated third ventricle leading to growth retardation, precocious or delayed [ijri.org]

Primary Amenorrhea

This syndrome commonly presents with delayed onset of puberty and decreased or absent sense of smell. [ncbi.nlm.nih.gov]

A standard 30-cell karyotyping analysis should be ordered in any female with primary amenorrhea, unexplained growth failure or delay in the onset of puberty, absent uterus [clinicaladvisor.com]

Abstract Investigation of primary amenorrhea is usually initiated by the age of 14 years if there is delayed puberty absent secondary sexual characteristics and absent menses [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism Type 18

All these data hypothesis delay of puberty these patients enhanced height Age (years) occurred onset of puberty. mechanism increased height presumed delayed epiphyseal fusion [factpub.org]

Delay in pubertal onset and subsequent normal sexual maturation as in constitutional delay of growth and puberty (CDGP) is well known. [ijem.in]

The onset of HH prior to adolescence results in delayed or absent puberty with the respective clinical consequences, whereas onset in adult life leads to hypogonadism with [rbej.biomedcentral.com]

Growth Hormone Deficiency

In fact, there are several other issues which can, and do, present themselves due to this condition: Growth rate below the 10-25th percentile Delayed onset of puberty Heart [krogerspecialtypharmacy.com]

[…] tooth development Delayed onset of puberty Symptoms of GH deficiency in adults include the following: Low energy Decreased strength and exercise tolerance Decreased muscle [emedicinehealth.com]

Short stature Low growth velocity (speed) for age and pubertal stage Increased amount of fat around the waist The child may look younger than other children his or her age Delayed [emedicinehealth.com]

Central Precocious Puberty Type 2

Treating Precocious Puberty With Medication Treatments are available to delay the onset of puberty, and they are typically well-tolerated. [everydayhealth.com]

[…] by on Sep 23, 2015 • 1:58 pm Early onset (and later onset/delayed puberty) is not uncommon with children who have a diagnosis of CP. [cpdailyliving.com]

This medicine slows the signs of puberty and delays the onset of menstruation in girls. [rileychildrens.org]

Laurence Moon Syndrome

There is a decreased level of gonadotrophic hormone production because of hypogonadism, which contributes to delay of onset of puberty and development of secondary sex characteristics [accessanesthesiology.mhmedical.com]

Conclusion Hypogonadism as another major criterion of the syndrome may be seen with delayed onset of puberty in both genders, hypogenitalism in males and genital anomalies [dentalnews.com]

Cardio-Facio-Cutaneous Syndrome

Endocrine Abnormalities Affected individuals can have growth hormone deficiency and early onset puberty. [rarediseases.org]

Endocrine evaluation is appropriate if onset of puberty is delayed beyond age 12 to 13 years. [ncbi.nlm.nih.gov]

Growth Delays Growth may be normal with appropriate birth weight and length; however, weight and length may drop to below the fifth percentile during early infancy while head [rarediseases.org]

Launois Syndrome

The more obvious and frequently encountered characteristics include delayed onset of puberty, short stature, small testes, and obesity. [rarediseases.org]

Onset in adolescence, usually prior to puberty and closing of the epiphyses of long bones, which show retarded skeletal growth. [whonamedit.com]

Signs & Symptoms Froehlich syndrome is characterized by increased or excessive eating that leads to obesity, small testes, and a delay in the onset of puberty. [rarediseases.org]

Disorder of Carbohydrate Metabolism

Normal mental development Growth failure Delayed onset of puberty Pseudocolitis resulting in diarrhea Renal stones Hypertension Deterioration of renal functions Changes in [lecturio.com]

Skeletal Dysplasia - Epilepsy - Short Stature Syndrome

[…] for first few months Short stature with: Period of severe growth deceleration lasting 1-3 yrs and may begin at less than 2 years Bone age lags chronological age Delayed onset [learn.pediatrics.ubc.ca]

[…] of puberty Absence of physical or psychological disease Final height consistent with mid-parental height There are 4 patterns of short stature due to pathological conditions [learn.pediatrics.ubc.ca]

Bardet-Biedl Syndrome Type 15

This may manifest as a small penis, failure of the testes to descend into the scrotum (termed “cryptorchidism”) or a delay in the onset of puberty. [rarediseases.org]

Short Stature - Wormian Bones - Dextrocardia Syndrome

onset of puberty, and cushingoid features -increased transaminases, dyslipidemia, and abdominal pain Imaging: -hepatomegaly and homogenous increased liver attenuation without [quizlet.com]

[…] carcinomas, cysts of the jaw, bifid ribs, cardiac fibroma -glycogen hepatopathy -pediatric pt w history of poorly controlled Type I diabetes mellitus -stunting of growth, delayed [quizlet.com]

ROHHAD Syndrome

[…] obesity, hyperprolactinemia, central hypothyroidism, disordered water balance, failed growth hormone stimulation test, corticotropin deficiency, or altered onset of puberty [obgynkey.com]

[…] or early-onset puberty, and low thyroid hormone.[3] Patients will also often experience a decelerated growth rate throughout childhood.[7] Sodium imbalance within the body [wikiwand.com]

(delayed or precocious), and (3) absence of PHOX2B mutation (to genetically distinguish ROHHAD from CCHS). [obgynkey.com]

Cerebellar Ataxia-Hypogonadism Syndrome

[…] from early childhood to the fourth decade, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). [monarchinitiative.org]

(up to the fifth-sixth decade) leading to variable degrees of visual impairment, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics [mendelian.co]

Cerebellar ataxia-hypogonadism syndrome is a very rare autosomal recessive neurodegenerative disorder characterized by the combination of progressive cerebellar ataxia with onset [monarchinitiative.org]

Isolated Growth Hormone Deficiency Type 2

Acroosteolysis-Keloid-Like Lesions-Premature Aging Syndrome

onset of puberty. 10- Other manifestations Chronic bronchitis Anemia Gorham-Stout-Haferkamp syndrome (lymphangiomatosis) First description: 1955, Gorham and associates. [lymphedemapeople.com]

8- Gastrointestinal manifestations Episodes of abdominal or flank pain, diarrhea, or vomiting Jejunal diverticula Peritonitis 9- Endocrine manifestations Abnromal growth Delayed [lymphedemapeople.com]

Precocious Puberty

This article focus on whether tea polyphenols could delay the onset of puberty by reducing leptin levels. [ncbi.nlm.nih.gov]

In children with untreated hypothyroidism, the onset of puberty is usually delayed, but gonadotropin-independent precocious puberty may occur in children with severe hypothyroidism [ncbi.nlm.nih.gov]

This medicine slows the signs of puberty and delays the onset of menstruation in girls. [rileychildrens.org]

Collins-Sakati-Nyhan Syndrome

[…] diabetes mellitus and delayed puberty. 61 Rachmiel M...Parvari R 21304230 2011 43 Sanjad-Sakati Syndrome in Sudanese children. 61 Arabi WA...Abdullah MA 27493305 2011 44 [malacards.org]

[…] two new families with a mutation in the C2orf37 gene. 61 Ben-Omran T...Teebi A 21964978 2011 42 Woodhouse-Sakati syndrome in an Israeli-Arab family presenting with youth-onset [malacards.org]

Gonadotropic Pituitary Adenoma

Constitutional delay of puberty (CDP), is a benign, often familial condition, in which puberty onset is significantly delayed, but eventually occurs and then proceeds normally [mayomedicallaboratories.com]

A standard 30-cell karyotyping analysis should be ordered in any female with primary amenorrhea, unexplained growth failure or delay in the onset of puberty, absent uterus [cancertherapyadvisor.com]

CDP is a benign, often familial, condition in which puberty onset is significantly delayed, but eventually occurs, and then proceeds normally. [mayomedicallaboratories.com]

Bardet-Biedl Syndrome Type 7

This may manifest as a small penis, failure of the testes to descend into the scrotum (termed “cryptorchidism”) or a delay in the onset of puberty. [rarediseases.org]

Tristichiasis

In both males and females, the mean height followed along the 3rd percentile until puberty, but decreased transiently due to an approximately 2-year delay in onset of puberty [lymphedemapeople.com]