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17 Possible Causes for Delayed Secondary Sexual Development, Kallmann Syndrome, Mutation in the KISS1 Receptor Gene

  • Kallmann Syndrome

    Some key molecules have been discovered through the study of the genetics of CHH. 1 Inactivating mutations in genes encoding kisspeptin-1 ( KISS1 ) 40 and its receptor ( KISS1R[doi.org] Kallmann syndrome is the result of a genetic defect.[symptoma.com] The delay in suitable treatment from the age of 16 to 22 meant I went six years with a very low testosterone level, with the subsequent delay in secondary sexual development[themighty.com]

  • Primary Male Hypogonadism

    gene (KISS1 receptor product)?[quizlet.com] A number of conditions can cause secondary hypogonadism, including: Kallmann syndrome.[mayoclinic.org] Tabs Content Clinical Overview Diagnosis Indications for Testing Signs and symptoms of hypogonadism Prepubertal Delayed development of secondary sexual characteristics Small[arupconsult.com]

  • Male Hypogonadism

    gene (KISS1 receptor product)?[quizlet.com] Disorders Causing Pituitary Hypogonadism Brain and pituitary tumors Hemochromatosis Kallmann syndrome Weight loss Obesity Diabetes Testicular Disorders Causing Hypogonadism[louisville.edu] Tabs Content Clinical Overview Diagnosis Indications for Testing Signs and symptoms of hypogonadism Prepubertal Delayed development of secondary sexual characteristics Small[arupconsult.com]

  • Hypogonadotropic Hypogonadism Type 8

    Mutations involving the genes GnRH1 and KISS1, are a very rare cause of HH [41], [42].[journals.plos.org] Kallmann syndrome - absent puberty with no sense of smell. Me at 18 years old in my final year at school. I had not started puberty yet.[imgur.com] […] pubertal onset, absent or poorly developed secondary sexual characteristics, primary amenorrhea, eunuchoid proportions or infertility.[ijdvl.com]

  • Hypogonadism

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] BACKGROUND: Congenital hypogonadotrophic hypogonadism (CHH) and Kallmann syndrome (KS) are caused by disruption to the hypothalamic-pituitary-gonadal (H-P-G) axis.[ncbi.nlm.nih.gov] Tabs Content Clinical Overview Diagnosis Indications for Testing Signs and symptoms of hypogonadism Prepubertal Delayed development of secondary sexual characteristics Small[arupconsult.com]

  • Kallmann Syndrome Type 3

    gene (KISS1 receptor product)?[quizlet.com] […] a b c d e f g h i "Kallmann syndrome".[en.wikipedia.org] Affected females usually present with primary amenorrhea and do not have a completed secondary sexual development, such as having little or no breast development. 3,4 KS and[hormones.gr]

  • Kallmann Syndrome Type 4

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] Kallmann syndrome can have a wide variety of additional signs and symptoms.[ghr.nlm.nih.gov] […] pubertal onset, absent or poorly developed secondary sexual characteristics, primary amenorrhea, eunuchoid proportions or infertility.[ijdvl.com]

  • Leydig Cell Hypoplasia due to LHB Deficiency

    Mutations of the GnRH1 gene have also been reported in patients with hypogonadotropic hypogonadism, although they are rare.[clinicalgate.com] syndrome and GnRH insensitivity[en.wikipedia.org] , impaired, or fully absent puberty with an associated reduction in or complete lack of development of secondary sexual characteristics ( sexual infantilism ), impaired fertility[en.wikipedia.org]

  • Hypogonadotropic Hypogonadism

    […] in the genes encoding GNRH1 or its receptor will result in the failure of the HPG axis and give rise to normosmic CHH. [2] Inactivating mutations of KISS1 or KISS1R causes[en.wikipedia.org] Patients with Kallmann's syndrome or idiopathic hypogonadotropic hypogonadism usually have absent puberty.[endobible.com] Gonadal steroid replacement is the preferred treatment for inducing and maintaining secondary sexual development until fertility is desired.[journals.lww.com]

  • Hypogonadotropic Hypogonadism Type 18

    […] two novel missense mutations in the gene encoding the GNRH receptor ( GNRHR1 : NM_000406.2; HGNC: 4421), see Figure 2.[journals.plos.org] syndrome", abstract "The genetic basis is unknown for 60{\%} of normosmic hypogonadotropic hypogonadism (nHH)/Kallmann syndrome (KS).[augusta.pure.elsevier.com] In the absence of exogenous hormone administration, secondary sexual characteristics fail to develop.[disorders.eyes.arizona.edu]