Delayed Speech and Language Development: Causes & Reasons

Possible Causes for Delayed Speech and Language Development

speech and language development Developmental regression EEG abnormality Increased neuronal autofluorescent lipopigment Myoclonus Seizure IMPORTANT NOTE: NIH does not independently [ncbi.nlm.nih.gov]

[…] autofluorescent lipopigment storage material Abnormality of the eye Progressive visual loss Abnormality of the nervous system Cerebellar ataxia Cerebellar atrophy Cerebral atrophy Delayed [ncbi.nlm.nih.gov]

GLUT1 Deficiency Syndrome

speech and language development Deficiency of speech development Delayed language development Delayed speech Delayed speech acquisition Delayed speech development Impaired [rarediseases.info.nih.gov]

speech and language abnormalities. [rarediseases.org]

speech and language development Impaired speech development Language delay Language delayed Language development deficit Late-onset speech development Poor language development [rarediseases.info.nih.gov]

X-linked Mental Retardation Type Cabezas

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Distal lower limb amyotrophy 0008944 Gait ataxia Inability to coordinate movements [rarediseases.info.nih.gov]

Hyperphosphatasia with Mental Retardation Type 2

Poor growth, microcephaly (1 patient), moderate to severe delayed speech and language development, plagiocephaly (1 patient), coronal synostosis (1 patient), hypertelorism [iofbonehealth.org]

speech and language development Short philtrum Epicanthus Autosomal dominant inheritance Sparse hair Hypoplasia of the corpus callosum Microcephaly Congenital onset Downslanted [mendelian.co]

Marked developmental delays with particularly delayed speech and language development were observed in all individuals studied here. [nature.com]

Neuronal Ceroid Lipofuscinosis Type 2

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Developmental regression Loss of developmental milestones Mental deterioration in [rarediseases.info.nih.gov]

Monosomy 13q14

Delayed speech and language development MedGen UID: 105318 •Concept ID: C0454644 • Finding A degree of language development that is significantly below the norm for a child [ncbi.nlm.nih.gov]

speech and language development Holoprosencephaly sequence Hypoplasia of the corpus callosum Intellectual disability Ear malformation Anteverted ears Hearing impairment Low-set [ncbi.nlm.nih.gov]

[…] ears Growth abnormality Growth delay Neoplasm Retinoblastoma GTR MeSH Orphanet CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar CROGVChromosome 13q14 deletion [ncbi.nlm.nih.gov]

Prader-Willi Syndrome

Impaired speech development Language delay Language delayed Language development deficit Late-onset speech development Poor language development Speech and language delay [rarediseases.info.nih.gov]

Speech and language therapy during childhood will help with impaired speech and delay in developing language. [yourhormones.info]

Deficiency of speech development Delayed language development Delayed speech Delayed speech acquisition Delayed speech development Impaired speech and language development [rarediseases.info.nih.gov]

Mucopolysaccharidosis

Otitis prone children are at risk of developing delayed speech and language development due to conductive hearing loss caused by recurrent AOM with effusion [34]. [smw.ch]

Mucopolysaccharidosis Type 2

COMPASSIONATE ALLOWANCE INFORMATION MPS II - HUNTER SYNDROME ALTERNATE NAMES Mucopolysaccharidosis type II; Iduronate sulfatase deficiency; MPS Disorder; MPS II; I2S Deficiency; Lysosomal Storage Disease – Mucopolysaccharidosis Type II DESCRIPTION MPS II – Hunter syndrome is a rare, inherited disease in which the[…] [secure.ssa.gov]

Propionic Acidemia

• Three siblings suffering from recurrent vomiting, hypotonia, hyperpnea, dehydration, and ketoacidosis were diagnosed as having ketotic hyperglycinemia secondary to propionic acidemia. They also had leukopenia and thrombocytopenia, and two of them had anorectal malformations, one an imperforate anus with[…] [jamanetwork.com]

Pallister W Syndrome

Synonyms of Pallister W Syndrome W Syndrome Disorder Subdivisions General Discussion Pallister W syndrome is a rare genetic disorder characterized by unusual facial features such as clefting of the palate and the upper lip, a broad flat nose, widely spaced slanted eyes, and/or downslanting eyelid folds (palpebral[…] [hekimce.com]

Mucopolysaccharidosis Type 7

Mucopolysaccharidosis type VII (Sly syndrome), a rare lysosomal storage disorder caused by deficiency of the enzyme β-glucuronidase, was first reported in 1973 in a two year old boy with hepatosplenomegaly, skeletal abnormalities and moderate mental retardation (1). MPS type VII is unusual amongst the MPS syndromes[…] [journals.lww.com]

Neuronal Ceroid Lipofuscinosis Type 7

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 EEG abnormality 0002353 Generalized myoclonic seizures 0002123 Global developmental [rarediseases.info.nih.gov]

Focal Epilepsy - Speech Disorder - Mental Retardation

Continuous spike-wave activity during sleep: clinical and electroencephalographical aspects Laura M.F. Ferreira Guilhoto Lúcia R. Machado-Haertel Maria Luíza G. Manreza Aron J. Diament Sobre os autores Resumos Dezessete crianças com espícula-onda contínua durante o sono foram estudadas retrospectivamente. Cinco[…] [scielo.br]

Trisomy X Syndrome

speech and language development, and difficulty reading Delayed motor skills, such as sitting and walking Problems processing sound Behavioral and emotional problems, including [everydayhealth.com]

While it causes no unique physical features, it may lead to learning disability, as well as delayed speech/language and motor development. [patientslikeme.com]

Delays in speech and language development are frequent. [contact.org.uk]

Short Stature due to Endocrine Disorder

Delayed speech and language development MedGen UID: 105318 • Concept ID: C0454644 • Finding A degree of language development that is significantly below the norm for a child [ncbi.nlm.nih.gov]

Klinefelter Syndrome with Male Phenotype with more than Two X Chromosomes

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Facial asymmetry Asymmetry of face Crooked face Unsymmetrical face [ more ] 0000324 [rarediseases.info.nih.gov]

Autosomal Recessive Primary Microcephaly Type 10

Cerebral atrophy Delayed speech and language development Clonus Gliosis Myoclonus Death in infancy Polyhydramnios Cerebellar hypoplasia Neuronal loss in central nervous system [mendelian.co]

speech and language development Visual impairment Exotropia Choreoathetosis Left ventricular noncompaction Athetosis Lethargy Gait disturbance Kyphoscoliosis Visual loss [mendelian.co]

Hyperreflexia Progressive microcephaly Cognitive impairment Abnormality of the cerebral white matter Cerebral calcification Brain atrophy Short stature Hearing impairment Growth delay [mendelian.co]

Wiedemann-Steiner Syndrome

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Depressed nasal tip Caved in nasal tip Depressed tip of nose Flat nasal tip Flat [rarediseases.info.nih.gov]

Dubowitz Syndrome

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Episodic vomiting 0002572 Facial asymmetry Asymmetry of face Crooked face Unsymmetrical [rarediseases.info.nih.gov]

Dysequilibrium Syndrome

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Dysarthria Difficulty articulating speech 0001260 Dysdiadochokinesis Difficulty performing [rarediseases.info.nih.gov]

Autosomal Recessive Centronuclear Myopathy

NA Y N Global developmental delay NA Y N Delayed fine motor development NA Y N Delayed gross motor development NA Y N Delayed speech and language development NA Y N Specific [playground.phenotips.org]

2-Aminoadipic 2-Oxoadipic Aciduria

speech and language development Global developmental delay Mild global developmental delay IMPORTANT NOTE: NIH does not independently verify information submitted to the [ncbi.nlm.nih.gov]

speech and language development ; Generalized hypotonia ; Global developmental delay ; Intellectual disability, mild ; Microcephaly ; Phenotypic variability Associated Genes [mousephenotype.org]

speech and language development;Microcephaly;Global developmental delay [ccgenomics.cn]

Infantile Choroidocerebral Calcification Syndrome

Lower limb asymmetry Sensorineural hearing impairment Muscular hypotonia Athetosis Delayed speech and language development Hemiplegia Leukoencephalopathy Choreoathetosis [mendelian.co]

Hemiplegia Athetosis Hemiparesis Progressive encephalopathy Infantile onset Progressive neurologic deterioration Intracranial hemorrhage Delayed speech and language development [mendelian.co]

speech and language development Tremor Oxycephaly Rigidity Poor speech Parkinsonism Dyskinesia Bradykinesia Resting tremor Slurred speech Megalencephaly Lewy bodies Cogwheel [mendelian.co]

Acrodysostosis

[…] hand Cone-shaped end part of finger bones 0010230 Congenital onset Symptoms present at birth 0003577 Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Delayed [rarediseases.info.nih.gov]

Klinefelter Syndrome with XY/XXY Mosaic

speech and language development. [icdlist.com]

Children with Klinefelter syndrome may have learning disabilities and delayed speech and language development. [biologystories.com]

speech and language development There is also an increased risk for breast cancer and systemic lupus erythematosus. [oncofertility.northwestern.edu]

Infantile-Onset Autosomal Recessive Non-Progressive Cerebellar Ataxia

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Dysmetria Lack of coordination of movement 0001310 Gait ataxia Inability to coordinate [rarediseases.info.nih.gov]

Chromosome 19q13.11 Deletion Syndrome

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Failure to thrive Faltering weight Weight faltering [ more ] 0001508 Feeding difficulties [rarediseases.info.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C4

[…] and language development Deficiency of speech development Delayed language development Delayed speech Delayed speech acquisition Delayed speech development Impaired speech [rarediseases.info.nih.gov]

[…] and language development Impaired speech development Language delay Language delayed Language development deficit Late-onset speech development Poor language development [rarediseases.info.nih.gov]

Speech and language delay Speech and language difficulties Speech delay [ more ] 0000750 Difficulty walking Difficulty in walking 0002355 Elevated serum creatine kinase Elevated [rarediseases.info.nih.gov]

Ring Chromosome 22

Speech and language development is delayed. At three years the child begins to walk. [ncbi.nlm.nih.gov]

Speech/Language delay Mostly all individuals with 9p deletions have a significant speech and language delay. [9pminus.org]