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1,410 Possible Causes for Delayed Speech Development, Duplication or Triplication of Phalanges, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] , particularly those with the greatest delays in speech and language development.[dseinternational.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

    Missing: Duplication or Triplication of Phalanges
  • Kleiner Holmes Syndrome

    […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] speech and language development Esophageal carcinoma Clinodactyly of the 5th toe Abnormality of the voice Chest pain Cough Nausea and vomiting Lymphadenopathy Kyphoscoliosis[mendelian.co] Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of[malacards.org]

  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] speech and language development Deficiency of speech development Delayed language development Delayed speech Delayed speech acquisition Delayed speech development Impaired[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

    Missing: Duplication or Triplication of Phalanges
  • Congenital Deafness

    This results in delayed speech/language development, social problems and academic difficulties.[pamf.org] Parental concerns about possible hearing loss or observed delays in speech development require auditory screening in any child.[ncbi.nlm.nih.gov] If they have a hearing loss that is undetected and untreated, they can miss much of the speech and language around them.[pamf.org]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Mental Retardation

    In addition to eye abnormalities, affected individuals may also have neurological abnormalities including diminished muscle tone (hypotonia), delays in speech development,[rarediseases.org] Children who are moderately retarded show noticeable delays in developing speech and motor skills.[humanillnesses.com] Delays in speech development are common and may become more obvious when contrasted with the speech development of a sibling.[web.archive.org]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Ring Chromosome 10

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] She had slight delay in psychomotor development, including speech delay. She could sit at the age of 9 months, and walk unsupported at the age of 12 months.[omicsonline.org] Schmidt et al. (1981) reported a 35-month-old girl of Puerto Rican descent with delayed psychomotor development, poor speech, and dysmorphic features, including high forehead[omim.org]

    Missing: Duplication or Triplication of Phalanges
  • Mucopolysaccharidosis

    […] in speech development may occur in conjunction with cognitive decline in severely affected children, and many patients never learn to speak in full sentences. 9,14 Patients[touchneurology.com] The patient developed normally until the age of 2 years when he was referred to a paediatric neurologist for suspected motor and speech delay.[ncbi.nlm.nih.gov] […] having non-neuronopathic disease may show a delay in acquiring language skills despite normal cognitive development, owing to hearing loss.[touchneurology.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • MELAS Syndrome

    Medical records showed that significantly more often than controls, carriers had delayed motor or speech development and reading or learning problems.[journals.lww.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • Mucopolysaccharidosis 2

    […] in speech development may occur in conjunction with cognitive decline in severely affected children, and many patients never learn to speak in full sentences. 9,14 Patients[touchneurology.com] Coarse facial features, hepatomegaly, hearing difficulties and delayed speech development are common. Life expectancy in attenuated forms may be limited to Figure 4b ).[touchophthalmology.com] The parents and the pediatrician had agreed to delay subspecialty referral until the effect of restored hearing on the boy’s speech development could be assessed.[consultant360.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe
  • SHORT Syndrome

    We describe a boy with the manifestations of the SHORT syndrome: lipoatrophy, delayed speech development, minor facial anomalies, clinodactyly, and short stature.[ncbi.nlm.nih.gov] […] in speech development and in dental eruption.[ncbi.nlm.nih.gov] Mild cognitive disorders have been described as well as delayed speech development can occur in childhood [ 1, 2, 3, 5, 6 ].[ijponline.biomedcentral.com]

    Missing: Duplication or Triplication of Phalanges Wide Space Between the First and Second Toe

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