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52 Possible Causes for Delayed Wound Healing, Easy Bruising, Melena

  • Malignant Neoplasm

    Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was[…][]

  • Hemophilia B

    bruising, excessive bleeding after surgery, trauma, dental procedures or circumcision; epistaxis, poor wound healing, intracranial hemorrhage, scalp hematoma, development[] Moderate or mild deficiency is associated with prolonged bleeding after tooth extractions, surgery, or injuries and recurrent or delayed wound healing.[] A full-term male, healthy newborn infant suddenly developed melena and rectal fresh blood oozing at age of 4 days.[]

  • Hemophilia A

    Affected individuals suffer hemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds.[] Moderate to mild deficiency is associated with prolonged bleeding after tooth extractions, surgery, or injuries and recurrent or delayed wound healing.[] […] joint (young children) Central nervous system (CNS) - Headache, stiff neck, vomiting, lethargy, irritability, spinal cord syndromes Gastrointestinal (GI) - Hematemesis, melena[]

  • Hemophilia

    Other symptoms include frequent episode of bleeding from gums, nose and mild cuts, and easy bruising.[] Signs and symptoms of GI involvement include: • Fever • Abdominal distention and pain • Melena (bloody stool) • Hip flexion contracture (iliopsoas muscle spasm due to retroperitoneal[] […] pain, stiffness, and refusal to use joint (children) CNS: Headache, stiff neck, vomiting, lethargy, irritability, and spinal cord syndromes Gastrointestinal: Hematemesis, melena[]

  • Factor XIII Deficiency

    They also had prolonged umbilical cord bleeding and history of delayed wound healing. Since childhood, they have been developing spontaneous ecchymotic spots.[] Genitourinary and gastrointestinal bleedings leading to hematuria, melena, or hematochezia are not typical of FXIIID, but may occur occasionally.[]

  • Sirolimus

    bruising/bleeding, mental/mood changes, swelling ankles /feet, severe headache , dizziness , stomach / abdominal pain , missed/heavy/painful periods, signs of kidney problems[] Impaired or delayed wound healing (esp. BMI 30kg/m 2 ). Hepatic impairment.[] The patient often displayed melena; she recently received transfusion of 2 units of red blood cells once every 2 weeks.[]

  • Fludrocortisone

    Skin: Skin thinning and atrophy, acne, impaired wound healing; petechiae, ecchymosis, easy bruising; suppression of skin test reaction; hypopigmentation or hyperpigmentation[] wound healing is possible Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated Latent tuberculosis may be reactivated (patients[] bruising irregular or absent menstrual periods If you experience any of the following symptoms, call your doctor immediately: skin rash swollen face, lower legs, or ankles[]

  • Acitretin

    (severe and continuing) redness of the face, neck, arms, and occasionally, upper chest redness of the skin sleeplessness stiff, painful muscles thinning of the skin with easy[] Acitretin can delay wound healing.[] […] earache, tinnitus, hearing loss, epistaxis, rhinitis, sinusitis, papilledema GI: nausea, vomiting, diarrhea, constipation, abdominal pain, gastritis, stomatitis, esophagitis, melena[]

  • Pseudoxanthoma Elasticum

    […] susceptibility Bruise easily Easy bruisability Easy bruising Once the ABCC6 mutations that cause PXE in a family are identified, unaffected relatives may be tested for the[] Also, GI bleeding is common, as it leads to hematemesis and melena.[] Intermittent claudication: Leg pain during walking that resolves at rest Signs and symptoms related to the gastrointestinal (digestive) tract include: Hematemesis (vomiting blood) Melena[]

  • Anemia

    bruising Milky nipple discharge (called galactorrhea ) Early puberty (mostly seen in children with severe, longstanding disease) Delayed puberty (often the first obvious[] […] growth and development Impaired wound and tissue healing The symptoms of anemia may resemble other blood disorders or medical problems.[] Although uncommon, if lung cancer patients present with anemia and melena, enteric metastasis should be part of the differential diagnosis.[]

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