Dementia & Dementia with Lewy Bodies & Progressive Action Tremor: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Dementia, Dementia with Lewy Bodies, Progressive Action Tremor,

Negated

None

Unsure

None

Possible Causes

Parkinson Disease

[…] reduction in speed and amplitude of repetitive actions) and at least one of the following: (i) muscular rigidity, (ii) 4–6 Hz rest tremor and (iii) postural instability not [doi.org]

[…] disease dementia (PDD), together known as the Lewy body dementias. [ncbi.nlm.nih.gov]

(hand, leg or jaw; low frequency [4–5 Hz], asymmetric, disappears with action) - Excellent response to levodopa (70%–100%) - Progressive disorder - Severe levodopa-induced [dx.doi.org]

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Parkinson's Disease Type 3

[…] reduction in speed and amplitude of repetitive actions) and at least one of the following: (i) muscular rigidity, (ii) 4–6 Hz rest tremor and (iii) postural instability not [academic.oup.com]

[…] or Lewy body dementia. [alz.org]

Dementia with Lewy bodies (DLB) Dementia with Lewy bodies (DLB) is a progressive, neurodegenerative disorder in which abnormal deposits of a protein called alpha-synuclein [parkinson.org]

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Neurodegenerative Disorder

tremor, myoclonus, hyper-reflexia, and focal limb dystonia. [aao.org]

Emerging diagnoses (37.4%) were dementia with Lewy bodies (DLB) in 29 subjects, Parkinson disease (PD) in 22, multiple system atrophy (MSA) in two, and mild cognitive impairment [ncbi.nlm.nih.gov]

Study population Adults referred with clinical diagnoses of frontotemporal dementia, motor neuron disorder, or related adult-onset neurodegenerative disorder. [clinicaltrials.gov]

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Carbon Monoxide-Induced Parkinsonism

[…] reduction in speed and amplitude or repetitive actions) and at least one of the following: Muscular rigidity. 4- to 6-Hz resting tremor. [patient.info]

Dementia with Lewy Bodies Dementia with Lewy bodies is a neurodegenerative disorder associated with abnormal protein deposits (Lewy bodies) found in certain areas of the brain [agingcare.com]

"Frontotemporal Dementias". Continuum (Minneap Minn) (Review). 22 (2 Dementia): 464–89. doi : 10.1212/CON.0000000000000300. PMC 5390934. PMID 27042904. [en.wikipedia.org]

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Striatonigral Degeneration

In addition, patients with MSA-C may have tremor with action, which is different from the resting tremor seen in typical Parkinson's disease. [bcm.edu]

They include multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and dementia with Lewy bodies. [diki.pl]

The features in this patient were consistent with those seen in subcortical dementia. She also had auditory hallucinations. [ncbi.nlm.nih.gov]

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Movement Disorder

[…] sixth decades of life • Tends to be slowly progressive • ET is a postural and action tremor, that tends to affect the hands, head, and voice • Made worse by anxiety • Senile [slideshare.net]

Lewy bodies, a variant of PD in which dementia occurs early and psychotic symptoms are common; Huntington's disease (HD), an inherited disorder that causes behavioral problems [ncbi.nlm.nih.gov]

dementia in multiple system atrophy (MSA) patients. [ncbi.nlm.nih.gov]

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Shy Drager Syndrome

In addition, patients with MSA-C may have tremor with action, which is different from the resting tremor seen in typical Parkinson's disease. [bcm.edu]

In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. [ncbi.nlm.nih.gov]

Age-related Dementia Age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. [meta.org]

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Neuronal Intranuclear Inclusion Disease

He was found to have significant action and sustention tremor, bilateral lower leg weakness (tibialis anterior), decreased deep tendon reflexes and pes planus. [path.upmc.edu]

الصفحة 169 - Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. ‏ [books.google.com]

We herein report the case of a patient who received an antemortem diagnosis of familial NIID with dementia-dominant phenotype that was later confirmed by an autopsy. [ncbi.nlm.nih.gov]

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Fatal Familial Insomnia

He consequently developed excessive sweating, bilateral action tremors, and restlessness. [karger.com]

[…] to be due to dementia with Lewy bodies. [ncbi.nlm.nih.gov]

Symptoms and course Dementia associated with sleep disorders. [alzheimer-europe.org]

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Progressive Myoclonic Epilepsy Type 3

action myoclonus, infrequent generalized seizures, and ataxia) or with proteinuria that progresses to renal failure.[42] Despite severe neurologic disability due mainly [thieme-connect.com]

These include criteria for the diagnosis of multiple sclerosis, dementia of Lewy-body type, frontal lobe dementias, chronic fatigue syndrome, and inflammatory neuropathies [books.google.de]

TARDBP Dementia, Lewy body SNCA Dent disease type 2 OCRL Dentatorubral-pallidoluysian atrophy ATN1 Developmental delay and microcephaly, SLC1A4 related SLC1A4 Developmental [centogene.com]

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Pallidopyramidal Syndrome

tremor Respiratory tract infection Limb muscle weakness Unsteady gait Oligohydramnios Involuntary movements Progressive muscle weakness Respiratory insufficiency due to muscle [mendelian.co]

Dementia, progressive Progressive dementia [ more ] 0000726 Lewy bodies 0100315 Percent of people who have these symptoms is not available through HPO Abnormality of extrapyramidal [rarediseases.info.nih.gov]

G. / Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36. [research.manchester.ac.uk]

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Unverricht-Lundborg Syndrome

AMRF typically presents at ages 15 to 25 years either with neurologic symptoms (including tremor, action myoclonus, seizures, and ataxia) or with proteinuria that progresses [ncbi.nlm.nih.gov]

EEG findings in dementia with Lewy bodies and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1999 Mar. 66(3):401-3. [medscape.com]

Hereditary dementia, and, historically, dementia praecox have been described in other family members. [mayoclinic.pure.elsevier.com]

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Lafora Disease

Mutations of this gene cause a progressive myoclonus epilepsy called action myoclonus–renal failure characterized by adult and rarely late-teenage onset progressive tremor [doi.org]

body dementias, frontotemporal dementia, vanishing white matter, vasculitis, normal pressure hydrocephalus, neuromyelitis optica, Kennedy disease, spinal muscular atrophy [books.google.com]

It is suggested that this type of presenile dementia may be a presenile form of Lafora disease. [ncbi.nlm.nih.gov]

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Autosomal Recessive Spastic Paraplegia Type 7

الصفحة 190 - Bradykinesia (slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions) • And at least one of the [books.google.com]

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet. [books.google.com]

[…] pugilistica Dementia with Lewy body Dentatorubral pallidoluysian atrophy Dentinogenesis imperfecta Denys-Drash syndrome Dermatomyositis Desminopathy Developmental anomaly [sanfordresearch.org]

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Extrapyramidal Disorder

The usual course is for gradual progression. 26-9. How do you recognize essential tremor? Answer 26-9. [dartmouth.edu]

body dementia Sudden onset of parkinsonian symptoms Vascular parkinsonism Physical Exam Dementia as first symptom Dementia with Lewy bodies Prominent orthostasis MSA-p Early [slideshare.net]

Clinical phenomena usually consist of a mixture of lower and upper motor neuron signs, dementia, and urinary dysfunction. [jnnp.bmj.com]

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Senile Chorea

It is an action tremor occurring during activity and is of greater amplitude when reaching for a target. [academic.sun.ac.za]

Prevention and AD References Introduction Vascular Cognitive ImpairmentVascular Dementia Lewy Body Disease Dementia with Lewy Bodies Progressive Supranuclear Palsy Corticobasal [books.google.com]

Senile chorea (SC) is characterized by the presence of late onset, generalized chorea with no family history and no dementia. [ncbi.nlm.nih.gov]

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Dentatorubral-Pallidoluysian Atrophy

Seite 190 - Bradykinesia (slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions) • And at least one of the following [books.google.de]

Huntington disease, Lewy Body Dementia, Parkinson disease, Prion disease, Progressive Supranuclear Palsy ( Vasaikar et al. (2013) BMC Neuroscience ). [bioschool.iitd.ac.in]

It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate [books.google.de]

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Olivopontocerebellar Atrophy

• Tremor - Postural, resting, or both Bradykinesia plus at least 1 parkinsonian feature Cerebellar Dysfunction • Gait ataxia (wide-based stance with steps of irregular length [physio-pedia.com]

The component of the inclusions, Alpha synuclein is also a component of Lewy bodies in sporadic Parkinsonism, dementia with Lewy bodies, and a rare variant of Alzheimer's [dizziness-and-balance.com]

The features in this patient were consistent with those seen in subcortical dementia. She also had auditory hallucinations. [ncbi.nlm.nih.gov]

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Autosomal Recessive Spinocerebellar Ataxia Type 17

Spinocerebellar ataxia type 12 (SCA12) is an autosomal dominant disorder characterized by action tremor of the upper extremities progressing to ataxia and other cerebellar [chginc.org]

Tauopathy : Alzheimer's ( Early-onset ) · Frontotemporal dementia / Frontotemporal lobar degeneration ( Pick's, Dementia with Lewy bodies ) Multi-infarct dementia Mitochondrial [thefullwiki.org]

It is characterized by a variable clinical picture which can include dementia, psychiatric disorders, parkinsonism, dystonia, chorea, spasticity, and epilepsy. [orpha.net]

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Neurodegeneration with Brain Iron Accumulation

Writer’s cramp and action-induced dystonic tremors may also be observed. [e-jmd.org]

in Parkinson's disease, dementia with Lewy bodies and NBIA-1. [ncbi.nlm.nih.gov]

We describe a case of late onset neurodegeneration with brain iron accumulation (NBIA) presenting as frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) [ncbi.nlm.nih.gov]

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Jankovic Rivera Syndrome

[…] myoclonic and atonic seizures, tremulousness/tremor, and sensorineural hearing loss. [ncbi.nlm.nih.gov]

Fourth, in patients with MCI with comorbid RBD who later develop dementia, postmortem examination shows Lewy-body pathology [28]. [journals.plos.org]

Symptoms - Jankovic Rivera syndrome * Progressive distal muscle weakness * Progressive distal muscle wasting * Myoclonic jerks * Dementia * Abnormal walk * Speech defect Causes [checkorphan.org]

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Progressive Myoclonic Epilepsy Type 8

Cortical tremor is a form of rhythmic myoclonus, presenting as postural or action tremor in some patients with progressive myoclonus epilepsy (PME), 76, 77 in Angelman syndrome [clinicalgate.com]

TARDBP Dementia, Lewy body SNCA Dent disease type 2 OCRL Dentatorubral-pallidoluysian atrophy ATN1 Developmental delay and microcephaly, SLC1A4 related SLC1A4 Developmental [centogene.com]

[…] by childhood to adolescent-onset of action myoclonus, generalized tonic-clonic seizures, and slowly progressive, moderate to severe cognitive impairment that may lead to dementia [orpha.net]

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Generalized Brain Atrophy

The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy [ncbi.nlm.nih.gov]

[…] with Lewy bodies G31.84 Mild cognitive impairment, so stated G31.85 Corticobasal degeneration G31.89 Other specified degenerative diseases of nervous system G31.9 Degenerative [icd10data.com]

Brown J: Chromosome 3-linked frontotemporal dementia. Cell Mol Life Sci 1998;54:925–927. [karger.com]

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Spastic Ataxia with Congenital Miosis

Additional features included action tremor, dysmetria, dysdiadochokinesis, dysarthria, and nystagmus. Cognitive development was normal. [findzebra.com]

[…] atrophy (19), and rarely dementia with Lewy bodies (20, 21). [neuroophthalmology.ca]

Access comprehensive discussions of Alzheimer and commonly occurring non-Alzheimer dementias (such as Lewy bodies disease and frontotemporal dementia) and traumatic brain [books.google.ro]

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Parkinsonism

nonfluent speech, and parkinsonian signs, but had no action-intention tremor and no gait ataxia. [ncbi.nlm.nih.gov]

The distribution of diagnoses was as follows: n 13, Parkinson's disease (PD); n 3, dementia with Lewy bodies (DLB); n 1, dementia (unspecified; profound); n 2, multiple system [ncbi.nlm.nih.gov]

[…] reduction in speed and amplitude or repetitive actions) and at least one of the following: Muscular rigidity. 4- to 6-Hz resting tremor. [patient.info]

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Multiple System Atrophy

• Tremor - Postural, resting, or both Bradykinesia plus at least 1 parkinsonian feature Cerebellar Dysfunction • Gait ataxia (wide-based stance with steps of irregular length [physio-pedia.com]

However, in the case of specific diseases, including Parkinson's disease, Multiple System Atrophy (MSA), and dementia with Lewy bodies (DLB), this protein forms aggregates [medicalxpress.com]

MSA does not provoke dementia but could impair some cognitive functions. [alzheimer-europe.org]

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Atypical Juvenile Parkinsonism

This is another progressive condition with no cure or treatment as yet. [mycareladies.co.uk]

[…] with Lewy bodies Progressive supranuclear palsy Corticobasal degeneration Prion diseases Amyotrophic-parkinson-dementia complex of Guam Pallidal degeneration Hemiatrophy [slideplayer.com]

[…] has a juvenile onset (usually in the early teens or early twenties) and manifests with pyramidal signs, dystonia, psychiatric (depression, anxiety, drug-induced psychosis, dementia [orpha.net]

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Essential Tremor

Characterised by a progressive tremor of the upper extremities, present in posture and action, without other neurological signs or symptoms. [bestpractice.bmj.com]

She also specializes in Parkinson’s-related conditions such as Dementia with Lewy Bodies, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration [pacificneuroscienceinstitute.org]

Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia. [ncbi.nlm.nih.gov]

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Adult-Onset Cervical Dystonia Type DYT23

[…] to other body sites and time course of progression Occurrence of dystonia at rest, with any specific voluntary action, or posture maintenance Presence or absence of tremor [misc.medscape.com]

TARDBP Dementia, Lewy body SNCA Dent disease type 2 OCRL Dentatorubral-pallidoluysian atrophy ATN1 Developmental delay and microcephaly, SLC1A4 related SLC1A4 Developmental [centogene.com]

Dementias, including Alzheimer's disease. Stroke. Motor neuron diseases. Neuropathies and channelopathies. Adult muscular dystrophies. Neurocutaneous syndromes. [books.google.com]

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Fragile X-Associated Tremor - Ataxia Syndrome

Core features of FXTAS include progressive action tremor and gait ataxia; with frequent, more variable features of cognitive decline, especially executive dysfunction, parkinsonism [ncbi.nlm.nih.gov]

and dementia with Lewy bodies. [jneurodevdisorders.biomedcentral.com]

dementia (AD). [ncbi.nlm.nih.gov]

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