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28 Possible Causes for Dementia, Difficulty Rising from a Squatting Position

  • Wernicke Encephalopathy

    Calf muscle tenderness, difficulty rising from a squatting position, and decreased vibratory sensation in the toes are early signs. Muscle wasting occurs.[merckmanuals.com] WE can mimic rapidly progressive dementia syndromes, such as Creutzfeldt-Jakob disease (CJD).[ncbi.nlm.nih.gov] Pellagra causes dementia, diarrhoea, or dermatitis, and can mimic non-specific erythaema in alcoholics.[ncbi.nlm.nih.gov]

  • Neurological Disorder

    rising from squatting position (use hands to ‘climb’ up legs – Gowers’ sign)  Pseudohypertrophy of calf muscles (muscle replaced by fatty tissue)  Progressive disability[slideshare.net] European Studies of Dementia .”[ncbi.nlm.nih.gov] Neurological disorders: public health challenges describes and discusses the increasing global public health importance of common neurological disorders such as dementia,[who.int]

  • Thiamine Deficiency

    The neuropathy affects the legs most markedly, and these patients have difficulty rising from a squatting position. [4] In our case, the patient had both features of wet and[jdrntruhs.org] […] found primarily in alcoholics are Wernicke’s encephalopathy (WE) and Korsakoff psychosis, which often combine as Wernicke-Korsakoff syndrome (WKS), ultimately leading to dementia[sovhealth.com] Alzheimer’s disease Scientists are studying the possibility that thiamin deficiency could affect the dementia of Alzheimer’s disease.[web.archive.org]

  • Pellagra

    On examination, the main features are wasting, anaesthetic patches (especially over the tibia), tenderness of the calves to pressure and difficulty in rising from the squatting[fao.org] It is characterized by 4 "D's": diarrhea, dermatitis, dementia, and death.[ncbi.nlm.nih.gov] It is characterized by 4 “D’s”: diarrhea, dermatitis, dementia, and death.[doi.org]

  • Inclusion Body Myopathy

    The most common reasons for presentation are related to weakness of the quadriceps muscles, such as difficulty rising from low chairs or from the squatting or kneeling positions[ibmmyositis.com] RESULTS: The clinical features of myopathy, Paget disease of bone, and semantic dementia (a clinical subtype of frontotemporal dementia) in our patients were similar to those[ncbi.nlm.nih.gov] No dementia or myopathies were revealed in the family history covering two generations.[ncbi.nlm.nih.gov]

  • Neuromuscular Junction Disorder

    One maneuver that may demonstrate weakness is to have the patient squat down and rise to the standing position without any assistance from their arms.[ahcmedia.com] Access comprehensive discussions of Alzheimer and commonly occurring non-Alzheimer dementias (such as Lewy bodies disease and frontotemporal dementia) and traumatic brain[books.google.com] […] medications * Uses of psychiatric medications for neurologic illnesses, such as antidepressants for migraine, chronic pain, and peripheral neuropathy; and antipsychotic agents for dementia[books.google.com]

  • Polyglucosan Body Myopathy Type 2

    Pelvic girdle Difficulty climbing stairs, waddling gait, difficulty rising to standing position from a squatting position (patient may demonstrate Gower sign), difficulty[sites.google.com] […] lateral sclerosis; Pagetoid neuroskeletal syndrome "ORPHA52430: Inclusion body myopathy with Paget disease of bone and frontotemporal dementia" .[en.wikipedia.org] Blueprint Genetics Amyotrophic Lateral Sclerosis Panel (test code NE2201): Test Specific Strength This panel covers genes implicated in patients with ALS and frontotemporal dementia[blueprintgenetics.com]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    They presented between the ages of 13 to 29 with proximal weakness in the lower extremities manifesting with difficulty on stairs or rising up from a squatting position (Table[bmcneurol.biomedcentral.com] Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia. 2007 May 25. In: Pagon, RA, et al, editors. GeneReviews( ) (Internet).[invitae.com] […] lateral sclerosis; Pagetoid neuroskeletal syndrome "ORPHA52430: Inclusion body myopathy with Paget disease of bone and frontotemporal dementia".[en.wikipedia.org]

  • Distal Myopathy

    Pelvic girdle Difficulty climbing stairs, waddling gait, difficulty rising to standing position from a squatting position (patient may demonstrate Gower sign), difficulty[sites.google.com] Inclusion body myopathy with Paget disease and frontotemporal dementia (IBMPFD) is caused by mutations in the valosin-containing protein (VCP) gene.[ncbi.nlm.nih.gov] VCP, dominantly inherited mutations in SQSTM1 are now associated with rimmed vacuolar myopathy, Paget disease of bone, amyotrophic lateral sclerosis, and frontotemporal dementia[ncbi.nlm.nih.gov]

  • Distal Myopathy Type 3

    Pelvic girdle Difficulty climbing stairs, waddling gait, difficulty rising to standing position from a squatting position (patient may demonstrate Gower sign), difficulty[sites.google.com] Paul Taylor and Rosa Rademakers, TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics, Neuron[doi.org] […] lateral sclerosis; Pagetoid neuroskeletal syndrome "ORPHA52430: Inclusion body myopathy with Paget disease of bone and frontotemporal dementia".[ipfs.io]

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