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5,471 Possible Causes for Dementia, EMG Shows Evidence of Reinnervation, Muscle Biopsy Abnormal

  • Motor Neuron Disease

    For patients with MND affecting the LMNs, the EMG will show evidence of: (1) acute denervation, which is ongoing as motor neurons degenerate, and (2) chronic denervation and[en.wikipedia.org] The results of electromyography and muscle biopsy were compatible with ALS. However, supranuclear vertical gaze palsy and slow saccades are seen.[ncbi.nlm.nih.gov] Frontotemporal dementia-motor neuron disease is now recognised as an important dementia syndrome, which presents substantial challenges for diagnosis and management.[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Only about 10% of ALS patients have abnormal nerve conduction study results, but the test can also suggest other diagnoses. A muscle biopsy.[webmd.com] These syndromes range from frontotemporal dementia to behavioral or cognitive syndromes.[ncbi.nlm.nih.gov] KEYWORDS: Amyotrophic lateral sclerosis; Autophagy; Autophagy-related genes; Disease-associated genes; Frontotemporal dementia[ncbi.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • MELAS Syndrome

    Electron microscopy of a muscle biopsy sample revealed mitochondria with abnormally arranged cristae and abnormal electron densities.[mja.com.au] […] encephalopathy, lactic acidosis and stroke like episodes) is a multisystem disorder characterized by short stature, vomiting, headache, cortical blindness, deafness and dementia[e-arm.org] MELAS is a form of dementia. It is caused by mutations in the genetic material (DNA) in the mitochondria.[medicinenet.com]

    Missing: EMG Shows Evidence of Reinnervation
  • MERRF Syndrome

    Biopsy: Abnormal mitochondria from under the muscle tissue membrane appear as “ragged red fibres” under a microscope Chemical staining identifies diseased mitochondria, appearing[lhsc.on.ca] Secondary features include dementia, optic atrophy, bilateral deafness, peripheral neuropathy, spasticity, or multiple lipomata.[en.wikipedia.org] Myoclonic epilepsy and ragged-red fibers (MERRF) syndrome is a rare disorder characterized by myoclonus, muscle weakness, cerebellar ataxia, heart conduction block, and dementia[ncbi.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Primary Lateral Sclerosis

    Muscle histology Deltoid muscle biopsies showed no mitochondrial abnormalities or dysfunction (Table 4 ). Muscle biopsies were normal in seven patients.[academic.oup.com] We report the occurrence of progressive spastic paraplegia and frontal systems dementia in a patient with postmortem features of PLS combined with moderate Alzheimer-like[ncbi.nlm.nih.gov] This case could be included with inclusion-associated disorders such as frontotemporal dementia or amyotrophic lateral sclerosis with dementia, and furthermore, predominant[ncbi.nlm.nih.gov]

    Missing: EMG Shows Evidence of Reinnervation
  • Lafora Disease

    […] and LBs in muscle and in skin tissue, without dementia.[ncbi.nlm.nih.gov] It is suggested that this type of presenile dementia may be a presenile form of Lafora disease.[ncbi.nlm.nih.gov] A muscle biopsy revealed, in both patients, the presence of PAS-positive and partially diastase-resistant cytoplasmic inclusions containing granular and filamentous amylopectin-like[link.springer.com]

    Missing: EMG Shows Evidence of Reinnervation
  • Unverricht-Lundborg Syndrome

    The ragged red fibres are a muscle biopsy feature caused by an accumulation of abnormal mitochondria.[aibolita.com] Hereditary dementia, and, historically, dementia praecox have been described in other family members.[mayoclinic.pure.elsevier.com] Muscle and skin biopsies on individual VI-7 were normal with no evidence of mitochondrial myopathy and no evidence of storage.[academic.oup.com]

    Missing: EMG Shows Evidence of Reinnervation
  • Multi-Infarct Dementia

    […] alterations 2 and the presence of an abnormal Notch3 immunostaining in skin biopsies is now used for diagnosis. 3 Ruchoux et al reported these typical vascular wall alterations[jnnp.bmj.com] Abstract Multi-infarct dementia (MID) indicates a dementia disorder primarily caused by multiple cerebral infarcts.[ncbi.nlm.nih.gov] Mixed dementia consists of a combination between multi-infarct and Alzheimer's dementia.[symptoma.com]

    Missing: EMG Shows Evidence of Reinnervation
  • Muscular Dystrophy

    This condition is typically characterized by large and abnormally distributed mitochondria on muscle biopsy, which can distinguish this condition from the other muscle conditions[ncbi.nlm.nih.gov] A non-DM1, non-DM2 multisystem myotonic disorder with frontotemporal dementia: phenotype and suggestive mapping of the DM3 locus to chromosome 15q21-24.[ncbi.nlm.nih.gov] Under the microscope, the muscle of a positive biopsy generally shows dead tissue and abnormally large muscle fibers.[cedars-sinai.edu]

    Missing: EMG Shows Evidence of Reinnervation
  • Alpers Syndrome

    Biopsy: Abnormal mitochondria from under the muscle tissue membrane appear as “ragged red fibres” under a microscope Chemical staining identifies diseased mitochondria, appearing[lhsc.on.ca] G31.09 Other frontotemporal dementia G31.1 Senile degeneration of brain, not elsewhere classified G31.2 Degeneration of nervous system due to alcohol G31.8 Other specified[icd10data.com] An extensive neurometabolic workup, including lactate determination in serum and CSF and muscle biopsy, disclosed no abnormalities.[ajnr.org]

    Missing: EMG Shows Evidence of Reinnervation

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