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3,428 Possible Causes for Dementia, Neuropathy

  • Vitamin B12 Deficiency

    Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually[ncbi.nlm.nih.gov] A clinical diagnosis of dementia with delirium was made.[doi.org] Participation included measuring vitamin B12 levels and assessing peripheral neuropathy using Neuropathy Total Symptom Score-6 (NTSS-6) questionnaire.[ncbi.nlm.nih.gov]

  • Amyloidosis

    Nerve conduction studies were consistent with multifocal demyelinating neuropathy.[ncbi.nlm.nih.gov] A series of 340 carriers of the TTRVal30Met mutation (180 symptomatic and 160 asymptomatic) underwent a neuropsychological assessment, which included the Dementia Rating Scale[ncbi.nlm.nih.gov] BACKGROUND: Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.[ncbi.nlm.nih.gov]

  • Sterol 27-Hydroxylase Deficiency

    Patients may experience extrapyramidal manifestations (dystonia and atypical parkinsonism), and peripheral neuropathy.[orpha.net] Peripheral neuropathy and extrapyramidal symptoms like dystonia and atypical parkinsonism may also be present.[symptoma.com] Genetic testing of the CYP27A1 gene is confirmatory and is increasingly being used as a first line test as part of symptom specific gene panels (genetic eye disease, ataxia, dementia[en.wikipedia.org]

  • Hereditary ATTR Amyloidosis

    Secondary objectives are to evaluate the effect of patisiran on Norfolk-Diabetic Neuropathy quality of life questionnaire score, nutritional status (as evaluated by modified[ncbi.nlm.nih.gov] […] b Department of Biological Sciences for Intractable Neurological Diseases , Institute for Biomedical Sciences, Shinshu University , Matsumoto , Japan. 3 c Department of Dementia[ncbi.nlm.nih.gov] In some patients, a leptomeningeal form that include ataxia, spastic paralysis, seizures, dementia and visual disturbances as most important symptoms may be seen.[symptoma.com]

  • Paraneoplastic Syndrome

    We suggest that paraneoplastic neuropathy should be considered during the management of trigeminal neuropathic pain, especially when brain imagery is normal.[ncbi.nlm.nih.gov] […] may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia[web.archive.org] Pittock, Autoimmune dementias, Non‐Alzheimer's and Atypical Dementia, (123-133), (2016). Nese Sinmaz, Tina Nguyen, Fiona Tea, Russell C.[doi.org]

  • Chronic Alcoholism

    In 42 patients (67.7%), we observed the presence of clinical and/or infraclinical neuropathy, mostly axonal, in 29 males (65.9%) and 13 females (72.2%).[ncbi.nlm.nih.gov] The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia.[ncbi.nlm.nih.gov] NUTRITIONAL – of course, can lead to Thiamine deficiency -- Wernicke/Korsakoff -- Dry and Wet Beriberi, Niacin deficiency -- Pellagra (diarrhea, dementia, dermatitis), Folate[errolozdalga.com]

  • Mercury Poisoning

    These findings are different from other peripheral neuropathies and may be characteristics of the late changes of the sural nerve induced by organic mercury compound.[ncbi.nlm.nih.gov] This is often labeled as dementia, autism, ADHD, Parkinson’s, depression, migraines, and more.[lahealthyliving.com] On the first follow-up visit performed 1 month after discharge, the neurological examinations of all patients were normal except for those patients with peripheral neuropathy[ncbi.nlm.nih.gov]

  • Orthostatic Hypotension

    Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities.[ncbi.nlm.nih.gov] […] disease and 95 (8.1%) had vascular dementia.[ncbi.nlm.nih.gov] Paraneoplastic neuropathies associated with leukemia are rare, and early diagnosis and treatment are crucial due to the potential for irreversible neurological deficits and[ncbi.nlm.nih.gov]

  • Adult Polyglucosan Body Disease

    A 50 year old patient is described who presented with parkinsonism, frontal dementia, peripheral neuropathy, neurogenic bladder, and upper motor neuron signs.[ncbi.nlm.nih.gov] CONCLUSIONS: It is important to consider APBD in cases of familial dementia of unknown etiology. Ante-mortem biopsy of axillary skin may be diagnostic.[ncbi.nlm.nih.gov] We highlight that peripheral neuropathy, deemed as disease hallmark, may be missing and that transient symptoms are confirmed as early disease manifestations.[ncbi.nlm.nih.gov]

  • Thiamine Deficiency

    Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann. Neurol. 54, 19–29 (2003). 11. Koike, H. et al.[dx.doi.org] […] found primarily in alcoholics are Wernicke’s encephalopathy (WE) and Korsakoff psychosis, which often combine as Wernicke-Korsakoff syndrome (WKS), ultimately leading to dementia[sovhealth.com] Alzheimer’s disease Scientists are studying the possibility that thiamin deficiency could affect the dementia of Alzheimer’s disease.[web.archive.org]

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