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595 Possible Causes for Dementia, Paresthesia, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] ., paresthesia, peripheral neuropathy, spinal cord degeneration), Psychiatric symptoms (irritability, personality change, depression), Cardiovascular problems (e.g., myocardial[kidsnewtocanada.ca] A clinical diagnosis of dementia with delirium was made.[doi.org]

  • Chronic Alcoholism

    People suffering from alcoholic neuropathy may feel burning and tingling sensations in their feet, which may persist or may last from a few months to a few years.[foundationforpn.org] The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia.[ncbi.nlm.nih.gov] NUTRITIONAL – of course, can lead to Thiamine deficiency -- Wernicke/Korsakoff -- Dry and Wet Beriberi, Niacin deficiency -- Pellagra (diarrhea, dementia, dermatitis), Folate[errolozdalga.com]

  • Pernicious Anemia

    The most common of these are paresthesias, weakness, clumsiness, and an unsteady gait.[web.archive.org] […] presentation mimicking a dementia of depression.[ncbi.nlm.nih.gov] We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov]

  • Subacute Combined Degeneration of Spinal Cord

    Most patients initially perceive tingling sensations or numbness in their limbs, most often in their legs.[symptoma.com] Discussion: Neurological manifestations of B12 deficiency include subacute combined degeneration (SCD), polyneuropathy, dementia, and optic nerve involvement.[shmabstracts.com] Mental changes range from mild forgetfulness to severe dementia or psychosis. Severe dementia is uncommon, but in some cases, it is the first symptom of the disorder.[nlm.nih.gov]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] A series of 340 carriers of the TTRVal30Met mutation (180 symptomatic and 160 asymptomatic) underwent a neuropsychological assessment, which included the Dementia Rating Scale[ncbi.nlm.nih.gov] Weakness, fatigue, weight loss, edema, paresthesias, light-headedness or syncope, dyspnea, purpura or bleeding, or change in the voice are the most common symptoms.[circ.ahajournals.org]

  • Thiamine Deficiency

    Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy.[ncbi.nlm.nih.gov] […] found primarily in alcoholics are Wernicke’s encephalopathy (WE) and Korsakoff psychosis, which often combine as Wernicke-Korsakoff syndrome (WKS), ultimately leading to dementia[sovhealth.com] Alzheimer’s disease Scientists are studying the possibility that thiamin deficiency could affect the dementia of Alzheimer’s disease.[web.archive.org]

  • Paraneoplastic Syndrome

    We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org] Therefore, people with this paraneoplastic syndrome typically experience: numbness, abnormal burning or tingling sensations in the distal extremities (paresthesia), severe[brighamandwomens.org] […] may include difficulty in walking or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia[ninds.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] The authors present the case of a 65-year-old woman who was admitted for paraparesis and paresthesias in the inferior limbs.[ncbi.nlm.nih.gov] We report a 58-year-old woman with DADS that progressed to a severe case of classic CIDP.[ncbi.nlm.nih.gov]

  • Hereditary ATTR Amyloidosis

    Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology . 2015;85(8):675-682. Hanna M.[hattramyloidosis.es] The first symptoms of TTR-FAP are paresthesia, pain or trophic foot injuries, gastrointestinal disorders and weight loss.[meetingcampus.com] […] b Department of Biological Sciences for Intractable Neurological Diseases , Institute for Biomedical Sciences, Shinshu University , Matsumoto , Japan. 3 c Department of Dementia[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy.[ncbi.nlm.nih.gov] CONCLUSIONS A case of a rare variant of GBS is presented with facial diplegia and paresthesia and with unilateral facial palsy.[ncbi.nlm.nih.gov] dementia FTLD , see GRN-related frontotemporal dementia FTLD with TDP-43 pathology , see GRN-related frontotemporal dementia FTLD-TDP , see GRN-related frontotemporal dementia[herenciageneticayenfermedad.blogspot.com]

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