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182 Possible Causes for Descending Paralysis, Muscle Weakness

  • Botulism

    Complaints included muscle weakness in the upper and lower limbs (N 5), dysphagia (N 5), dizziness (N 2), dyspnoea (N 2), dysphonia (N 2), dysarthria (N 2), fatigue (N 1),[ncbi.nlm.nih.gov] Clostridium botulinum is known to cause descending paralysis in infants throughout the world.[ncbi.nlm.nih.gov] If untreated, illness might progress to cause descending paralysis of respiratory muscles, arms and legs.[web.archive.org]

  • Wound Botulism

    By history, the most common symptoms were dysphagia (66%), proximal muscle weakness of upper and lower extremity (60%), neck flexor muscle weakness (33%), ophthalmoplegia[ncbi.nlm.nih.gov] BACKGROUND: Botulism is an acute neurologic illness characterized by cranial nerve palsies and descending flaccid paralysis.[ncbi.nlm.nih.gov] For the reported patient, maximum inspiratory force measurements were the only reliable indicator of respiratory muscle weakness.[ncbi.nlm.nih.gov]

  • Inhalational Botulism

    The muscle weakness tends to start in the shoulder area and move downwards through the body.[softschools.com] Recognition of the clinical presentation characterized by bulbar palsies and descending paralysis in the absence of sensory or central nervous systems symptoms is key to making[ohsu.pure.elsevier.com] The classic presentation is then a symmetrical, descending motor paralysis in an awake patient who has no sensory deficits.[disastermedicine.wordpress.com]

  • Intestinal Botulism

    BACKGROUND: Botulism is a potentially fatal infection characterized by progressive muscle weakness, bulbar paralysis, constipation and other autonomic dysfunctions.[ncbi.nlm.nih.gov] Intestinal colonization botulism, rare in adults, should be considered for patients with descending paralysis, especially those with a preceding alteration in small bowel[ncbi.nlm.nih.gov] Clinical features Neurological symptoms Descending paralysis Peripheral flaccid muscle paralysis that descends caudally Typically begins in frequently used muscles Pupils:[amboss.com]

  • Food-Borne Botulism

    In infants, symptoms include constipation, a flat facial expression, poor feeding, a weak cry, decreased movement, trouble swallowing, excessive drooling, muscle weakness,[kidshealth.org] Botulism classically presents as acute symmetrical descending flaccid paralysis.[ncbi.nlm.nih.gov] The classic syndrome of botulism is a symmetrical, descending motor paralysis in an alert patient, with no sensory deficits.[emedicine.medscape.com]

  • Infantile Botulism

    The patient presented with progressive muscle weakness, hypotonia, suckling and swallowing problems and absent peripheral reflexes at clinical examination.[ncbi.nlm.nih.gov] Note that, in many cases, descending paralysis may be absent.[symptoma.com] On discharge 3 months after admission he still had muscle weakness and required feeding by a nasogastric tube.[poison.org]

  • Miller-Fisher Syndrome

    Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent[ncbi.nlm.nih.gov] As mentioned earlier, descending paralysis is a characteristic manifestation of Miller Fisher syndrome.[buzzle.com] Typical Miller Fisher syndrome (MFS) lacks limb muscle weakness, but some patients may unpredictably progress to severe Guillain-Barré syndrome.[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    But weakness that increases over several days is also common. Muscle weakness or loss of muscle function (paralysis) affects both sides of the body.[nlm.nih.gov] Differential diagnosis Acute myelopathy – back pain,sphincter disturbances Botulism –early loss of pupillaryactivity,descending paralysis Diphtheria –early oropharyngeal involvement[slideshare.net] paralysis) Heavy metal intoxication (confusion, psychosis, organic brain syndrome) Hypophosphatemia (irritable, apprehensive, hyperventilation, normal cerebrospinal fluid[aafp.org]

  • Polyneuropathy

    After eliminating possible factors, septic shock-induced respiratory muscle weakness was suspected.[ncbi.nlm.nih.gov] It is critical to recognize this condition since it can progress rapidly to respiratory paralysis and life-threatening autonomic instability.[dartmouth.edu] Clinically, they manifest as limb and respiratory muscle weakness.[ncbi.nlm.nih.gov]

  • Motor Neuron Disease

    […] wasting and weakness, absent reflexes, loss of weight and muscle twitching.[mndnsw.asn.au] We report a heterozygous I113F mutation in a patient with familial ALS characterized by early and predominant bilateral vocal cord paralysis followed by descending spinal[ncbi.nlm.nih.gov] Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles.[ncbi.nlm.nih.gov]

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