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1,166 Possible Causes for destabilize

  • Influenza

    […] comprehensive pandemic influenza planning is profound: an influenza pandemic starting today may have major international consequences, including global economic and political destabilization[web.archive.org]

  • Sunburn

    Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.[ncbi.nlm.nih.gov] GTF2E2 mutations destabilize the general transcription factor complex TFIIE in individuals with DNA repair-proficient trichothiodystrophy.[ncbi.nlm.nih.gov]

  • TTR Amyloidosis with Cardiomyopathy

    Both types of TTR-CM share common pathophysiology of TTR tetramer destabilization leading to amyloid deposition and cardiac symptoms.[cathlabdigest.com] Eidos aims to halt TTR amyloidosis by treating the root cause of the disease, destabilized and misfolded TTR.[eidostx.com] TTR gene mutations are thought to destabilize the protein and cause tetramer dissociation into monomers, which aggregate into amyloid fibrils.[hattrguide.com]

  • UV-Sensitive Syndrome

    Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair . Nat.[doi.org] Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 . Mol. Cell 18 , 565–576 (2005). 31. Wei, L. et al.[doi.org]

  • UV-Sensitive Syndrome 1

    Additional Disease Information for UVSSA No data available for Genatlas for UVSSA Gene Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled[genecards.org]

  • Colchicine

    Together, our data establish QAs as colchicine-site ligands and explain the molecular mechanism of microtubule destabilization by this class of compounds.[ncbi.nlm.nih.gov] In the present investigation we examined whether taxane-resistant breast cancer cells are more sensitive to microtubule destabilizing agents including vinca alkaloids and[ncbi.nlm.nih.gov] Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Hyper-IgE Syndrome

    Computer modeling predicted that 81% of AD-HIES mutations are destabilizing.[ncbi.nlm.nih.gov] Tweardy Blood 2016 :blood-2016-02-702373; doi: Key points Most AD-HIES mutations destabilize STAT3 protein, contributing to impaired STAT3 function.[bloodjournal.org] Results: Computer modeling analysis predicted that 37/39 (95%) single amino acid substitution AD HIES mutations are destabilizing, and that these mutations can be divided[idsa.confex.com]

  • Lipoprotein Glomerulopathy

    Furthermore, these lipoprotein particles were thermodynamically destabilized and aggregation prone.[ncbi.nlm.nih.gov] Recent findings have suggested that mutation-induced folding perturbations in apoE lead to structural destabilization and aggregation, effects that may underlie lipoprotein[ncbi.nlm.nih.gov] […] case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I. ( 29356944 ) Takasaki S....Saito T. 2018 10 Thermodynamic destabilization[malacards.org]

  • Barth Syndrome

    We found a destabilization of the supercomplex (respirasome) I III2 IVn but also decreased amounts of individual complexes I and IV and supercomplexes I III and III IV.[vivo.med.cornell.edu] McKenzie M, Lazarou M, Thorburn DR and Ryan MT (2006) Mitochondrial respiratory chain supercomplexes are destabilized in Barth syndrome patients.[els.net] Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients . J. Mol. Biol 361 , 462-469.[doi.org]

  • TTR Amyloidosis with Polyneuropathy

    The mutation in the TTR gene causes the destabilization of the physiologically tetrameric protein.[centogene.com] These mutations induce conformational changes that destabilize the protein, causing aggregation in the form of amyloid fibrils, present both in hereditary forms of amyloidosis[ivami.com] In the setting of genetic mutations, destabilization of the TTR tetrameric structure and subsequent degradation to dimers and monomers is thought to be the main pathophysiological[symptoma.com]

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