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1,166 Possible Causes for destabilize

  • Influenza

    […] comprehensive pandemic influenza planning is profound: an influenza pandemic starting today may have major international consequences, including global economic and political destabilization[]

  • Sunburn

    Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.[] GTF2E2 mutations destabilize the general transcription factor complex TFIIE in individuals with DNA repair-proficient trichothiodystrophy.[]

  • TTR Amyloidosis with Cardiomyopathy

    Both types of TTR-CM share common pathophysiology of TTR tetramer destabilization leading to amyloid deposition and cardiac symptoms.[] Eidos aims to halt TTR amyloidosis by treating the root cause of the disease, destabilized and misfolded TTR.[] TTR gene mutations are thought to destabilize the protein and cause tetramer dissociation into monomers, which aggregate into amyloid fibrils.[]

  • UV-Sensitive Syndrome

    Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair . Nat.[] Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 . Mol. Cell 18 , 565–576 (2005). 31. Wei, L. et al.[]

  • UV-Sensitive Syndrome 1

    Additional Disease Information for UVSSA No data available for Genatlas for UVSSA Gene Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled[]

  • Colchicine

    Together, our data establish QAs as colchicine-site ligands and explain the molecular mechanism of microtubule destabilization by this class of compounds.[] In the present investigation we examined whether taxane-resistant breast cancer cells are more sensitive to microtubule destabilizing agents including vinca alkaloids and[] Colchicine binding site of tubulin is one of the most important pockets that have been focused on to design tubulin-destabilizing agents.[]

  • Autosomal Dominant Hyper-IgE Syndrome

    Computer modeling predicted that 81% of AD-HIES mutations are destabilizing.[] Tweardy Blood 2016 :blood-2016-02-702373; doi: Key points Most AD-HIES mutations destabilize STAT3 protein, contributing to impaired STAT3 function.[] Results: Computer modeling analysis predicted that 37/39 (95%) single amino acid substitution AD HIES mutations are destabilizing, and that these mutations can be divided[]

  • Lipoprotein Glomerulopathy

    Furthermore, these lipoprotein particles were thermodynamically destabilized and aggregation prone.[] Recent findings have suggested that mutation-induced folding perturbations in apoE lead to structural destabilization and aggregation, effects that may underlie lipoprotein[] […] case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I. ( 29356944 ) Takasaki S....Saito T. 2018 10 Thermodynamic destabilization[]

  • Barth Syndrome

    We found a destabilization of the supercomplex (respirasome) I III2 IVn but also decreased amounts of individual complexes I and IV and supercomplexes I III and III IV.[] McKenzie M, Lazarou M, Thorburn DR and Ryan MT (2006) Mitochondrial respiratory chain supercomplexes are destabilized in Barth syndrome patients.[] Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients . J. Mol. Biol 361 , 462-469.[]

  • TTR Amyloidosis with Polyneuropathy

    The mutation in the TTR gene causes the destabilization of the physiologically tetrameric protein.[] These mutations induce conformational changes that destabilize the protein, causing aggregation in the form of amyloid fibrils, present both in hereditary forms of amyloidosis[] In the setting of genetic mutations, destabilization of the TTR tetrameric structure and subsequent degradation to dimers and monomers is thought to be the main pathophysiological[]

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