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656 Possible Causes for Developmental Regression

  • Neuronal Ceroid Lipofuscinosis

    A patient presented with rapid developmental regression whose MRI findings suggested a leukodystrophy, but nerve, muscle, skin, and bone marrow biopsies were unrevealing.[] A 4-year-old male presented with a 2-year history of epilepsy and progressive developmental regression.[] A 4-year-old boy presented with intractable epilepsy and developmental regression starting 1 year previously.[]

  • Vitamin B12 Deficiency

    Severe vitamin B(12) deficiency produces a cluster of neurological symptoms in infants, including irritability, failure to thrive, apathy, anorexia, and developmental regression[] Three months later, developmental regression and failure to thrive led to the diagnosis of vitB(12) deficiency, as a consequence of a subclinical pernicious anaemia with vitB[] These patients can present with unexpected signs and symptoms, such as developmental delay and regression as in our patient.[]

  • Kohlschütter-Tönz Syndrome

    Kohlschutter-tonz syndrome (KTS) is a rare neurodegenerative disorder that presents with seizures, developmental regression, characteristic hypoplastic dental enamel indicative[] regression and characteristic hypoplastic dental enamel indicative of amelogenesis imperfecta besides dysmorphologies.[] regression.[]

  • West Syndrome

    None of the patients showed developmental regression following surgery.[] Here, we report a one-year, six-month-old girl with complex partial seizures who developed infantile spasms, developmental regression, and hypsarrhythmia during the two weeks[] regression.[]

  • Alpers Syndrome

    All patients manifested developmental delay or regression, refractory epilepsy, and biochemical liver dysfunction.[] Dementia is typically episodic, and unremitting seizures may contribute to developmental regression as well.[] Seizures may be difficult to control and unrelenting seizures can cause developmental regression as well.[]

  • Peripheral Neuropathy

    We describe a consanguineous girl exhibiting severe developmental regression, intractable epilepsy, polyneuropathy, and profound hypomyelination with cortical involvement.[] It is characterized by late infantile onset, severe psychomotor regression, epilepsy, and leukodystrophy.[]

  • Childhood Disintegrative Disorder

    The occurrence of developmental regression in autism is one of the more puzzling features of this disorder.[] Abstract The occurrence of developmental regression in autism is one of the more puzzling features of this disorder.[] The condition is characterized by sudden onset and severe developmental regression between 3 and 5 years of age after previously normal development.[]

  • Neuronal Ceroid Lipofuscinosis 4

    regression Loss of developmental milestones Mental deterioration in childhood [ more ] 0002376 Neurological speech impairment Speech disorder Speech impairment Speech impediment[] Abnormality of metabolism/homeostasis Laboratory abnormality Metabolism abnormality [ more ] 0001939 Abnormality of movement Movement disorder Unusual movement [ more ] 0100022 Developmental[]

  • Traumatic Brain Injury

    Global developmental delay and developmental regression, David Michelson, MD and Stephen Ashwal, MD 08.[]

  • Cardiomyopathy

    CASE: A 6-month-old girl with no remarkable family or past medical history until 1 month prior presented with developmental regression and feeding impairment.[]

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