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197 Possible Causes for Difficulty Climbing Stairs, Muscle Biopsy Abnormal

  • Muscular Dystrophy

    This condition is typically characterized by large and abnormally distributed mitochondria on muscle biopsy, which can distinguish this condition from the other muscle conditions[ncbi.nlm.nih.gov] Symptoms may include: Progressive muscle weakness and wasting (atrophy) Waddling way of walking Difficulty climbing stairs Difficulty rising from lying or sitting Repeated[cedars-sinai.edu] Symptoms may include: Clumsy movement Difficulty climbing stairs Frequently trips and falls Unable to jump or hop normally Tip toe walking Leg pain Tiring quickly with exertion[chop.edu]

  • Duchenne Muscular Dystrophy

    Diagnosis of Duchenne Muscular Dystrophy A muscle biopsy (taking a sample of muscle) for dystrophin studies can be done to look for abnormal levels of dystrophin in the muscle[disabled-world.com] climbing stairs, hopping, or jumping decreased motor skills Physical exam Evaluation Differential Diagnosis Similar traits to Duchenne's Distinguishing traits from Duchenne's[orthobullets.com] […] fibers) For Duchenne and Becker muscular dystrophies, muscle biopsy may show whether dystrophin, a muscle protein, is missing or abnormal, and DNA testing is used to analyze[webmd.com]

  • Becker Muscular Dystrophy

    Electromyography was abnormal in all patients. Muscle biopsy in 1 patient demonstrated normal immunostaining for dystrophin.[ncbi.nlm.nih.gov] As the condition progresses, muscle weakness leads to functional difficulties (difficulty climbing stairs or rising from a chair).[orpha.net] Elevated serum CK Skeletal muscle biopsy showing decreased dystrophin quantity Panel overlap The gene on this panel is also included on our Autism Intellectual Disability[unmc.edu]

  • Polymyositis

    Muscle biopsy abnormalities at some time during their disease: i. degeneration and regeneration of muscle fibers ii. necrosis iii. phagocytosis iv. interstitial mononuclear[clinicaltrials.gov] climbing stairs, getting up from a chair, or lifting above the shoulder Joint pain or muscle tenderness Difficulty swallowing Shortness of breath Fatigue General malaise[tuh.templehealth.org] Laboratory testing showed elevated muscle enzymes and myopathic abnormalities on electromyographic examination.[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy abnormalities in two individuals very early in the course of their disease suggest that biopsy would probably be useful in detection of preclinical disease in[pediatrics.aappublications.org] climbing stairs or getting up from chairs.[sharecare.com] Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, extramuscular involvement, and muscle biopsy findings.[ncbi.nlm.nih.gov]

  • Dermatomyositis

    Muscle biopsy abnormalities at some time during their disease: i. degeneration and regeneration of muscle fibers ii. necrosis iii. phagocytosis iv. interstitial mononuclear[clinicaltrials.gov] Muscle weakness may lead to difficulty climbing stairs, getting up from a sitting position or even raising the arms.[news-medical.net] Muscle biopsy abnormalities at some time during their disease: Muscle fiber destruction; Muscle fiber regeneration; Perivascular and interstitial inflammatory infiltrates[clinicaltrials.gov]

  • Glycogen Storage Disease Type 2

    Autophagy in Pompe mouse models The morphological evidence for abnormal autophagy in muscle biopsies from adult Pompe patients was first reported by Andrew Engel in 1970 ([ncbi.nlm.nih.gov] climbing stairs Frequent falls Scapular winging Respiratory Frequent infections Respiratory insufficiency Cardio-respiratory failure (death) Respiratory failure/insufficiency[cuh.nhs.uk] […] running 30 (32%) • Difficulty performing sports 22 (23%) • Difficulty climbing stairs 24 (26%) • Difficulty walking 15 (16%) • Difficulty rising from an armchair 11 (12%)[ojrd.com]

  • Childhood Dermatomyositis

    The subsequent list, derived from the first survey, comprised MRI abnormalities suggestive of inflammatory myositis; calcinosis; changes on muscle biopsy typical of myositis[rheumatology.oxfordjournals.org] Raised bumps on knuckes Gradual muscle weakness (often in the neck, shoulders, trunk, back or hips) Difficulty with everyday activities, such as climbing stairs, standing[my.clevelandclinic.org] […] in climbing stairs or combing hair, progressing to an inability to roll over in bed.[ijpd.in]

  • Spinal Muscular Atrophy

    Muscle biopsies showed typical signs of neurogenic damage. Molecular genetic analysis showed mutations of the ASAH1 gene.[ncbi.nlm.nih.gov] Symptoms may include: Difficulty rising from a seated position Trouble climbing stairs Trembling hands The onset of spinal muscular atrophy Type 4 often does not occur until[cedars-sinai.edu] In some situations other tests such as an EMG electromyography (EMG) or muscle biopsy may be needed because it is not possible to conduct the SMN gene tests or no abnormality[genome.gov]

  • Adult Spinal Muscular Atrophy

    Muscle biopsy- reveals evidence of devervation with no other structural abnormalities.[en.wikibooks.org] Symptoms may include: Difficulty rising from a seated position Trouble climbing stairs Trembling hands The onset of spinal muscular atrophy Type 4 often does not occur until[cedars-sinai.edu] In some situations other tests such as an EMG electromyography (EMG) or muscle biopsy may be needed because it is not possible to conduct the SMN gene tests or no abnormality[genome.gov]

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