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55 Possible Causes for Difficulty Climbing Stairs, Muscle Biopsy showing Variation In Fiber Size

  • Muscular Dystrophy

    Symptoms may include: Progressive muscle weakness and wasting (atrophy) Waddling way of walking Difficulty climbing stairs Difficulty rising from lying or sitting Repeated[] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[] Symptoms may include: Clumsy movement Difficulty climbing stairs Frequently trips and falls Unable to jump or hop normally Tip toe walking Leg pain Tiring quickly with exertion[]

  • Becker Muscular Dystrophy

    As the condition progresses, muscle weakness leads to functional difficulties (difficulty climbing stairs or rising from a chair).[] The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[] Abstract: Case report regarding a 23 year old gentleman, presented with difficulty climbing stairs, changes in posture and toe walking.[]

  • Duchenne Muscular Dystrophy

    climbing stairs, hopping, or jumping decreased motor skills Physical exam Evaluation Differential Diagnosis Similar traits to Duchenne's Distinguishing traits from Duchenne's[] This muscle weakness causes a waddling gait and difficulty climbing stairs.[] Symptoms progressive weakness affecting proximal muscles first (begins with gluteal muscle weakness) gait abnormalities delayed walking toe walking clumsy, waddling gait difficulty[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2B

    climbing stairs and walking.[] EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[] Examples of this include trouble standing from a sitting position without using the arms, or difficulty climbing stairs.[]

  • Limb-Girdle Muscular Dystrophy

    climbing stairs or getting up from chairs.[] Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[] Muscle biopsy shows evidence of a dystrophy with random variation in fiber size and evidence of degeneration and regeneration. Type one fibers may predominate.[]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G

    climbing stairs Difficulty walking up stairs 0003551 Difficulty running 0009046 Difficulty walking Difficulty in walking 0002355 Distal lower limb amyotrophy 0008944 Distal[] climbing stairs and walking.[] There was a history of difficulty with standing from a sitting position, climbing stairs and raising his upper limbs above his head.[]

  • Polymyositis

    climbing stairs, getting up from a chair, or lifting above the shoulder Joint pain or muscle tenderness Difficulty swallowing Shortness of breath Fatigue General malaise[] The muscle biopsy showed loss of fascicular architecture, variation in fiber size with atrophic fibers, and degenerating and regenerating fibers with adipose tissue infiltration[] You’ll have difficulty climbing stairs, getting up from a chair, or lifting objects with your arms.[]

  • Oculopharyngeal Muscular Dystrophy

    […] running, walking quickly and climbing stairs.[] Muscle biopsy in the four affected patients showed variation in fiber size, and the presence of small angulated fibers and occasional rimmed vacuoles.[] A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[]

  • Dermatomyositis

    Muscle weakness may lead to difficulty climbing stairs, getting up from a sitting position or even raising the arms.[] Muscle biopsy from a patient with polymyositis showing endomysial inflammatory cells (arrows) and variations of fiber size without a specific pattern (C, H&E 40 ).[] You’ll have difficulty climbing stairs, getting up from a chair, or lifting objects with your arms.[]

  • Classic Multiminicore Myopathy

    climbing stairs Multiple joint contractures Abnormality of mitochondrial metabolism Slender finger Recurrent lower respiratory tract infections Follicular hyperkeratosis[] Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[] There was history of difficulty in standing from sitting position, climbing stairs and running. He also had difficulty in drinking and eating.[]

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