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598 Possible Causes for Difficulty Climbing Stairs, Muscle Biopsy showing Variation In Fiber Size, Onset between 6 and 14 Years

  • Limb-Girdle Muscular Dystrophy

    climbing stairs or getting up from chairs.[] Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[] Early motor milestones: Most normal; Toe walking common Range: 2 to 45 years; Median 14 to 20 years; 71% between 6 to 18 years Weakness: Proximal legs; Rectus abdominus No[]

  • Muscular Dystrophy

    Symptoms may include: Progressive muscle weakness and wasting (atrophy) Waddling way of walking Difficulty climbing stairs Difficulty rising from lying or sitting Repeated[] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[] Symptoms may include: Clumsy movement Difficulty climbing stairs Frequently trips and falls Unable to jump or hop normally Tip toe walking Leg pain Tiring quickly with exertion[]

    Missing: Onset between 6 and 14 Years
  • Becker Muscular Dystrophy

    Abstract: Case report regarding a 23 year old gentleman, presented with difficulty climbing stairs, changes in posture and toe walking.[] The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[] As the condition progresses, muscle weakness leads to functional difficulties (difficulty climbing stairs or rising from a chair).[]

    Missing: Onset between 6 and 14 Years
  • Duchenne Muscular Dystrophy

    climbing stairs, hopping, or jumping decreased motor skills Physical exam Evaluation Differential Diagnosis Similar traits to Duchenne's Distinguishing traits from Duchenne's[] This muscle weakness causes a waddling gait and difficulty climbing stairs.[] Symptoms progressive weakness affecting proximal muscles first (begins with gluteal muscle weakness) gait abnormalities delayed walking toe walking clumsy, waddling gait difficulty[]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2B

    Age at onset ranged from 15 to 25 years with difficulty in climbing stairs, fatigue, weakness, and markedly elevated serum creatine kinase.[] LGMD1 patients may need to use walking aids, can have difficulties climbing stairs and lose the ability to walk.[] climbing stairs and walking.[]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2G

    climbing stairs Difficulty walking up stairs 0003551 Difficulty running 0009046 Difficulty walking Difficulty in walking 0002355 Distal lower limb amyotrophy 0008944 Distal[] climbing stairs and walking.[] Children have easy falls and difficulty in climbing stairs and getting up from ground.[]

    Missing: Onset between 6 and 14 Years
  • Distal Myopathy Type 3

    Eventually, affected individuals may have difficulty climbing stairs or walking for an extended period of time.[] Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[] Age of onset of initial symptoms varied between patients: In family A (Fig. 1A ), while patient 6 was symptomatic already at 2 years of age, patients 1, 5 and 7 recall initial[]

  • Polymyositis

    Progressive muscle weakness starts in the proximal muscles (muscles closest to the trunk of the body) which eventually leads to difficulties climbing stairs, rising from a[] The muscle biopsy showed loss of fascicular architecture, variation in fiber size with atrophic fibers, and degenerating and regenerating fibers with adipose tissue infiltration[] climbing stairs, getting up from a chair, or lifting above the shoulder Joint pain or muscle tenderness Difficulty swallowing Shortness of breath Fatigue General malaise[]

    Missing: Onset between 6 and 14 Years
  • Oculopharyngeal Muscular Dystrophy

    […] running, walking quickly and climbing stairs.[] Muscle biopsy in the four affected patients showed variation in fiber size, and the presence of small angulated fibers and occasional rimmed vacuoles.[] A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[]

    Missing: Onset between 6 and 14 Years
  • Dermatomyositis

    Muscle weakness may lead to difficulty climbing stairs, getting up from a sitting position or even raising the arms.[] Muscle biopsy from a patient with polymyositis showing endomysial inflammatory cells (arrows) and variations of fiber size without a specific pattern (C, H&E 40 ).[] Muscle weakness Muscle pain or tenderness Difficulty climbing stairs, getting into a car, or getting up out of a chair A reddish-purple skin rash on the face, knuckles, neck[]

    Missing: Onset between 6 and 14 Years

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