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598 Possible Causes for Difficulty Climbing Stairs, Muscle Biopsy showing Variation In Fiber Size, Onset between 6 and 14 Years

  • Limb-Girdle Muscular Dystrophy

    climbing stairs or getting up from chairs.[sharecare.com] Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] Early motor milestones: Most normal; Toe walking common Range: 2 to 45 years; Median 14 to 20 years; 71% between 6 to 18 years Weakness: Proximal legs; Rectus abdominus No[neuromuscular.wustl.edu]

  • Muscular Dystrophy

    Symptoms may include: Progressive muscle weakness and wasting (atrophy) Waddling way of walking Difficulty climbing stairs Difficulty rising from lying or sitting Repeated[cedars-sinai.edu] Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] Symptoms may include: Clumsy movement Difficulty climbing stairs Frequently trips and falls Unable to jump or hop normally Tip toe walking Leg pain Tiring quickly with exertion[chop.edu]

    Missing: Onset between 6 and 14 Years
  • Becker Muscular Dystrophy

    Abstract: Case report regarding a 23 year old gentleman, presented with difficulty climbing stairs, changes in posture and toe walking.[um.edu.mt] The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] As the condition progresses, muscle weakness leads to functional difficulties (difficulty climbing stairs or rising from a chair).[orpha.net]

    Missing: Onset between 6 and 14 Years
  • Duchenne Muscular Dystrophy

    climbing stairs, hopping, or jumping decreased motor skills Physical exam Evaluation Differential Diagnosis Similar traits to Duchenne's Distinguishing traits from Duchenne's[orthobullets.com] This muscle weakness causes a waddling gait and difficulty climbing stairs.[genome.gov] Symptoms progressive weakness affecting proximal muscles first (begins with gluteal muscle weakness) gait abnormalities delayed walking toe walking clumsy, waddling gait difficulty[orthobullets.com]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2B

    Age at onset ranged from 15 to 25 years with difficulty in climbing stairs, fatigue, weakness, and markedly elevated serum creatine kinase.[checkorphan.org] LGMD1 patients may need to use walking aids, can have difficulties climbing stairs and lose the ability to walk.[mdfgauteng.org] climbing stairs and walking.[rarediseases.org]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2G

    climbing stairs Difficulty walking up stairs 0003551 Difficulty running 0009046 Difficulty walking Difficulty in walking 0002355 Distal lower limb amyotrophy 0008944 Distal[rarediseases.info.nih.gov] climbing stairs and walking.[rarediseases.org] Children have easy falls and difficulty in climbing stairs and getting up from ground.[annalsofian.org]

    Missing: Onset between 6 and 14 Years
  • Distal Myopathy Type 3

    Eventually, affected individuals may have difficulty climbing stairs or walking for an extended period of time.[ghr.nlm.nih.gov] Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[jmedicalcasereports.biomedcentral.com] Age of onset of initial symptoms varied between patients: In family A (Fig. 1A ), while patient 6 was symptomatic already at 2 years of age, patients 1, 5 and 7 recall initial[bmcmedgenet.biomedcentral.com]

  • Polymyositis

    Progressive muscle weakness starts in the proximal muscles (muscles closest to the trunk of the body) which eventually leads to difficulties climbing stairs, rising from a[ninds.nih.gov] The muscle biopsy showed loss of fascicular architecture, variation in fiber size with atrophic fibers, and degenerating and regenerating fibers with adipose tissue infiltration[annalsofian.org] climbing stairs, getting up from a chair, or lifting above the shoulder Joint pain or muscle tenderness Difficulty swallowing Shortness of breath Fatigue General malaise[tuh.templehealth.org]

    Missing: Onset between 6 and 14 Years
  • Oculopharyngeal Muscular Dystrophy

    […] running, walking quickly and climbing stairs.[nhs.uk] Muscle biopsy in the four affected patients showed variation in fiber size, and the presence of small angulated fibers and occasional rimmed vacuoles.[ncbi.nlm.nih.gov] A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[nhs.uk]

    Missing: Onset between 6 and 14 Years
  • Dermatomyositis

    Muscle weakness may lead to difficulty climbing stairs, getting up from a sitting position or even raising the arms.[news-medical.net] Muscle biopsy from a patient with polymyositis showing endomysial inflammatory cells (arrows) and variations of fiber size without a specific pattern (C, H&E 40 ).[doi.org] Muscle weakness Muscle pain or tenderness Difficulty climbing stairs, getting into a car, or getting up out of a chair A reddish-purple skin rash on the face, knuckles, neck[childrens.com]

    Missing: Onset between 6 and 14 Years

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