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1,038 Possible Causes for Difficulty Running, Muscle Biopsy showing Variation In Fiber Size, Onset between 6 and 14 Years

  • Duchenne Muscular Dystrophy

    Children with DMD may have an unusual walk and difficulty running, climbing stairs, and getting up from the floor. [2] DMD may also affect learning and memory, as well as[rarediseases.info.nih.gov] […] with running and frequent falls by school age the child usually has developed a ‘waddling’ walking pattern and is walking on their toes due to increasing weakness of the[novita.org.au] Difficulty running or jumping because of weakness in leg muscles Frequent falls, stumbling, and difficulty climbing stairs Difficulty standing from a lying or sitting position[orthoinfo.aaos.org]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2B

    EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[checkorphan.org] Other characteristics include inability to walk on the toes and difficulty running or walking.[egl-eurofins.com] […] in running and limping during walking.[ncbi.nlm.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] This causes unusual walking gait, difficulty running, and usually eventual loss of the ability to walk.[geneaware.clinical.bcm.edu] Early motor milestones: Most normal; Toe walking common Range: 2 to 45 years; Median 14 to 20 years; 71% between 6 to 18 years Weakness: Proximal legs; Rectus abdominus No[neuromuscular.wustl.edu]

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] They have difficulty running, jumping, climbing stairs, and rising from the floor.[merckmanuals.com] Difficulty running or jumping because of weakness in leg muscles Frequent falls, stumbling, and difficulty climbing stairs Difficulty standing from a lying or sitting position[web.archive.org]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2G

    […] climbing stairs Difficulty walking up stairs 0003551 Difficulty running 0009046 Difficulty walking Difficulty in walking 0002355 Distal lower limb amyotrophy 0008944 Distal[rarediseases.info.nih.gov] Affected children may have difficulty climbing stairs and running. Affected individuals often need a wheelchair by the third or fourth decade.[rarediseases.org] […] symptoms is not available through HPO Areflexia of lower limbs 0002522 Autosomal recessive inheritance 0000007 Calf muscle hypertrophy Increased size of calf muscles 0008981 Difficulty[rarediseases.info.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Becker Muscular Dystrophy

    The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] Other symptoms include: Loss of muscle in affected areas Back pain Trouble lifting objects Difficulty running Fast heartbeat (palpitations) or irregular heartbeat How serious[webmd.com] Muscle weakness causes: Difficulty in walking, which worsens overtime and is lost usually by the ageof 25-30 Falling frequently Difficulty in jumping, running and climbing[kidbones.net]

    Missing: Onset between 6 and 14 Years
  • Multicore Myopathy with External Ophthalmoplegia

    running ; Exercise-induced myalgia ; External ophthalmoplegia ; Facial palsy ; Feeding difficulties in infancy ; Generalized muscle weakness ; High palate ; Hydrops fetalis[mousephenotype.org] running in childhood * Wasting of neck muscles * Wasting of shoulder girdle muscles * Scoliosis * Facial muscle weakness Causes - Myopathy congenital multicore with external[checkorphan.org] Since birth, digits of both hands were kept in permanent flexion and he had great difficulty in opening them.[scielo.br]

    Missing: Onset between 6 and 14 Years
  • Distal Myopathy Type 3

    Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[jmedicalcasereports.biomedcentral.com] A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[nhs.uk] Age of onset of initial symptoms varied between patients: In family A (Fig. 1A ), while patient 6 was symptomatic already at 2 years of age, patients 1, 5 and 7 recall initial[bmcmedgenet.biomedcentral.com]

  • Rigid Spine Syndrome

    Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[cags.org.ae] There was history of difficulty in running and getting up from stairs.[bioline.org.br] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[ncbi.nlm.nih.gov]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 1F

    Muscle biopsy reveal myopathic or dystrophic changes with variation in fiber size, central nuclei, fiber splitting, degeneration of muscle fibers, and an increase in connective[egl-eurofins.com] Some patients present in early childhood with mildly delayed walking and difficulty running and jumping, whereas others present as adults with mainly pelvic-girdle weakness[ncbi.nlm.nih.gov] running.[lgmd-info.org]

    Missing: Onset between 6 and 14 Years

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