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47 Possible Causes for Difficulty Walking, 'Eye of the Tiger' Sign on MRI

  • Juvenile Paralysis Agitans of Hunt

    Patients with PD have poor balance, a tendency to fall, and difficulty walking.[neupsykey.com] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] It being asked if whilst walking he felt much apprehension from the difficulty of raising his feet, if he saw a rising pebble in his path?[academic.oup.com]

  • Jankovic Rivera Syndrome

    After a few years of normal development, affected children begin experiencing muscle weakness and atrophy in the lower limbs, causing difficulty walking and frequent falls[ghr.nlm.nih.gov] Pantothenate kinase 2 mutation with classic pantothenate-kinase-associated neurodegeneration without ‘eye-of-the-tigersign on MRI in a pair of siblings.[e-jmd.org] Syndromes Itchy skin Breast development in men Antibiotics to fight bacterial infection How to set up your home to save energy Difficulty or poor balance when walking Enlarged[nhha.org]

  • Acute Cerebellar Ataxia

    walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea and vomiting Lightheadedness[cookchildrens.org] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Symptoms associated with acute cerebellar ataxia include: Coordination impairment in arms, legs and torso Unsteady gait Difficulty walking, frequent stumbling Nystagmus (repetitive[topclassactions.com]

  • Alcoholic Cerebellar Degeneration

    Symptoms may include: problems with learning and memory, including amnesia forgetfulness poor coordination difficulty walking Alcoholic neuropathy This condition occurs when[healthline.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] These patients will have difficulty when walking in tandem.[mdedge.com]

  • Hallervorden-Spatz Syndrome

    Case Report A 6 year old male child born to a second degree consanguinous married couple came with presenting complaints of difficulty in walking and repeated falls since[medresearch.in] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] The rest of her neurological examination, including extraocular movements, was normal except for slight unsteadiness when walking and mild difficulty with tandem gait.[jnnp.bmj.com]

  • Infantile Neuroaxonal Dystrophy

    The clinical picture includes upper and lower motor neuron deficits, including progressive weakness, difficulty in walking, hypotonia, muscle atrophy, hyperactive reflexes[pediatricneurologybriefs.com] The MRI usually shows an area of hyperintensity in the medial globus pallidus that has been called the ‘eye of the tigersign but this is not pathognomonic.[disorders.eyes.arizona.edu] […] in walking, demonstrating unsteadiness and/or a tendency to fall.[frostybabyblues.blogspot.com]

  • Subacute Cerebellar Degeneration

    walking.[rarediseases.info.nih.gov] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] […] as faced during first attack that is difficulty in walking with imbalance and scanning dysarthria.[pubs.sciepub.com]

  • Neurodegeneration with Brain Iron Accumulation

    All had progressive cognitive and motor regression first noted between 9 months and 6 years of age that typically first manifested as difficulty walking (ataxia).[ncbi.nlm.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] The disorder is caused by a mutation on a gene located on the X chromosome, which is why Madison, now 3, can’t speak, has difficulty walking, and lacks other motor skills.[dailynews.com]

  • X-linked Parkinsonism-Spasticity Syndrome

    Balance difficulty, often worse when walking in the dark or on uneven surfaces is not uncommon in individuals with HSP.[rarediseases.org] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[ojrd.biomedcentral.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    MPAN commonly begins with difficulty walking.[ghr.nlm.nih.gov] None of our pa-tients exhibited the eye of the tiger sign on T2-weighted MRI.[docslide.net] A 14-year-old boy presented with progressive difficulty in walking.[pediatricneurosciences.com]

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