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24 Possible Causes for Difficulty Walking, Muscle Biopsy showing Presence of Vacuoles

  • Glycogen Storage Disease Type 2

    Affected individuals often suffer from limb-girdle syndrome and claim walking difficulties.[symptoma.com] Muscle biopsy in Pompe disease shows the presence of vacuoles that stain positively for glycogen.[dx.doi.org] […] running 30 (32%) • Difficulty performing sports 22 (23%) • Difficulty climbing stairs 24 (26%) • Difficulty walking 15 (16%) • Difficulty rising from an armchair 11 (12%)[ojrd.com]

  • Paramyotonia Congenita

    Muscle biopsy - A muscle biopsy showing vacuoles confirms the presence of non-specific myopathy; however, it does not confirm a diagnosis of paramyotonia congenita.[symptoma.com] A positive test is characterized by two key findings in affected muscles: compound muscle action potentials are decreased and weakening of the muscle with exercise.[symptoma.com]

  • Hypokalemic Periodic Paralysis

    Patients may complain of an unusual heaviness of the lower limbs and this may be the sole complains in the mild disease. [1,2,3,4] Difficulty on walking Patients initially[explainmedicine.com] Thus the initial paralysis usually affects the lower limbs making the walking difficult during the attack. [2,4,5] Reduced urine output Accumulation of the water in the muscle[explainmedicine.com] […] present with difficulty in extending/flexing the proximal parts of the lower limbs such as hips and knees and the weakness of the thigh or calves.[explainmedicine.com]

  • Oculopharyngeal Muscular Dystrophy

    In some cases, muscle weakness of the legs may eventually cause difficulty walking. OPMD may be inherited as an autosomal dominant or recessive trait. READ MORE HERE[slodrinks.com] Muscle biopsy in the four affected patients showed variation in fiber size, and the presence of small angulated fibers and occasional rimmed vacuoles.[ncbi.nlm.nih.gov] Orthopedic devices such as canes, leg braces, or walkers can assist individuals who have difficulty walking.[rarediseases.info.nih.gov]

  • Myositis

    BACM can cause difficulty walking due to severe calf pain. Laboratory results show increased serum creatinine kinase and AST.[ncbi.nlm.nih.gov] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com] Symptoms of IBM include: difficulty walking tripping and loss of balance frequent falls trouble rising from a seated position weakened hand grip and diminished hand and finger[healthline.com]

  • Distal Myopathy Type 3

    The symptoms tend to progress slowly and include a loss of fine motor skills and difficulty walking.[healthline.com] The electromyograhy (EMG) shows a myopatic pattern and the muscles biopsy reveals dystrophic changes without the presence of rimmed vacuoles 1,4.[scielo.br] A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[nhs.uk]

  • Inclusion Body Myositis

    Signs and symptoms Frequent falls Difficulty walking Trouble climbing stairs or standing from a seated position A foot that seems to drop when walking, causing tripping Weakened[myositis.org] Muscle biopsy will also show rimmed vacuoles (abnormal cellular structures that are also called inclusion bodies), amyloid deposits (presence of abnormal proteins), and endomysial[hss.edu] She presented with weakness and walking difficulty and reported dyspnea on exertion. CPK was increasing as well (271 IU/l).[karger.com]

  • Granulomatous Myositis

    58275 What treatment is recommended for Granulomatous Myositis Some features of body myositis, muscle wastage causing unsteadiness walking, and extreme difficulty climbing[healthmagic.gq] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com] The T-cell receptor repertoire observed in lymphocytes that have been isolated from the muscles of these patients shows restriction when compared to the lymphocytes of the[rheumatologyadvisor.com]

  • Focal Myositis

    Walking and Ataxia 415 Case 66 A Man with Progressive Neuropathy and Congestive Heart Failure 422 Case 67 An Elderly Woman with a Progressive Neuropathy 429 Case 68 A Young[books.google.com] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com] By 2009, she had difficulty walking up steps and lifting her arms over her head. She stopped the atorvastatin on her own, but saw no improvements in weakness.[the-rheumatologist.org]

  • Myopathy, Endocrine

    Walking and Ataxia 415 Case 66 A Man with Progressive Neuropathy and Congestive Heart Failure 422 Case 67 An Elderly Woman with a Progressive Neuropathy 429 Case 68 A Young[books.google.com] Muscle biopsy shows inflammation of muscle, fibre necrosis and the presence of vacuoles and filamentous inclusions in fibres (seen by electron microscopy).[somalidoc.com] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com]

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