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3,413 Possible Causes for Difficulty Walking, Muscle Biopsy showing Variation In Fiber Size, Onset between 6 and 14 Years

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] […] is usually unable to walk Frequent falls Difficulty getting up from the floor and climbing stairs Difficulty with running, hopping, and jumping Loss of muscle mass Toe walking[medlineplus.gov] variation in muscle fiber size not segregated by motor unit.[merckmanuals.com]

    Missing: Onset between 6 and 14 Years
  • Becker Muscular Dystrophy

    The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[ncbi.nlm.nih.gov] […] is usually unable to walk Frequent falls Difficulty getting up from the floor and climbing stairs Difficulty with running, hopping, and jumping Loss of muscle mass Toe walking[nlm.nih.gov] Muscle biopsy revealed mild myopathic features including variation in fiber size and a few necrotic and regenerating muscle fibers.[doi.org]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy

    Muscle biopsy can show diffuse variation in fiber size, necrosis, regeneration and fibrosis.[dnatesting.uchicago.edu] Early motor milestones: Most normal; Toe walking common Range: 2 to 45 years; Median 14 to 20 years; 71% between 6 to 18 years Weakness: Proximal legs; Rectus abdominus No[neuromuscular.wustl.edu] This means that people may have frequent falls, and may have difficulty walking longer distances, climbing stairs and getting up from the floor.[musculardystrophyuk.org]

  • Limb-Girdle Muscular Dystrophy Type 2G

    […] climbing stairs Difficulty walking up stairs 0003551 Difficulty running 0009046 Difficulty walking Difficulty in walking 0002355 Distal lower limb amyotrophy 0008944 Distal[rarediseases.info.nih.gov] Related phenotypes are difficulty walking and areflexia of lower limbs Disease Ontology : 12 An autosomal recessive limb-girdle muscular dystrophy that has material basis[malacards.org] Muscle weakness usually affects the muscles of the pelvic and hip area first and affected individuals may have difficulty standing from a sitting position or walking up stairs[rarediseases.org]

    Missing: Onset between 6 and 14 Years
  • Limb-Girdle Muscular Dystrophy Type 2B

    EMG showed myopathic changes and skeletal muscle biopsies showed severe myopathic changes with variation of fiber size, fiber splitting, increased connective tissue, and some[checkorphan.org] Outstanding symptoms are difficulty walking, climbing stairs, and frequent falls due to lower limb involvement.[wohproject.org] Difficulties in rising from a chair or toilet seat and difficulties in climbing stairs are common.[encyclopedia.com]

    Missing: Onset between 6 and 14 Years
  • Duchenne Muscular Dystrophy

    DMD symptoms may include: difficulty walking a loss of ability to walk enlarged calves learning disabilities, which occurs in about one-third of affected individuals a lack[healthline.com] walking.[orthobullets.com] Physical Exam Symptoms progressive weakness affecting proximal muscles first (begins with gluteal muscle weakness) gait abnormalities delayed walking toe walking clumsy, waddling[orthobullets.com]

    Missing: Onset between 6 and 14 Years
  • Distal Myopathy Type 3

    Figure 2 Immunohistochemistry, immunoblotting and molecular genetic analysis. ( A ) Micrograph of the muscle biopsy of the right gastrocnemius muscle showing markedly increased[jmedicalcasereports.biomedcentral.com] Age of onset of initial symptoms varied between patients: In family A (Fig. 1A ), while patient 6 was symptomatic already at 2 years of age, patients 1, 5 and 7 recall initial[bmcmedgenet.biomedcentral.com] The symptoms tend to progress slowly and include a loss of fine motor skills and difficulty walking.[healthline.com]

  • Congenital Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[ncbi.nlm.nih.gov] Breathing difficulties may go unnoticed initially, and may be experienced prior to difficulties with walking.[disabled-world.com] Muscle biopsy in all our patients showed a dystrophic picture with extensive pericellular fibrosis, fiber size variation, and rounding.[annalsofian.org]

    Missing: Onset between 6 and 14 Years
  • Vitamin B12 Deficiency

    walking Muscle weakness Irritability Memory loss Dementia Depression Psychosis Treatment for Vitamin B12 Deficiency Vitamin B12 deficiency treatment depends on the cause.[blogs.naturalnews.com] Vitamin B 12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet difficulty walking (staggering, balance problems) anemia[health.harvard.edu] […] remain for a long time, the condition also can lead to irreversible damage to nerve cells, which can cause the following symptoms: Numbness and tingling in the hands and feet Difficulty[blogs.naturalnews.com]

    Missing: Muscle Biopsy showing Variation In Fiber Size Onset between 6 and 14 Years
  • Muscular Dystrophy-Dystroglycanopathy Type B5

    In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[ncbi.nlm.nih.gov] Clinical features include weakness of the hip and shoulder girdle, difficulty walking, spinal abnormalities including scoliosis, lordosis and kyphosis, and cardiomyopathy.[sema4.com] Most individuals are able to walk independently although because of progressive spinal rigidity and scoliosis they may experience difficulties walking later during life.[rarediseases.org]

    Missing: Onset between 6 and 14 Years

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