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207 Possible Causes for Diffuse Hypomyelination, Polyspike on Photic Stimulation

  • Unverricht-Lundborg Syndrome

    There are generalized polyspike discharges at rest that are exacerbated by photic stimulation. Fig. 2 EEG of individual V-13 at age 35 years.[academic.oup.com] Alan O'Brien, Christian R Marshall, Susan Blaser, Peter N Ray and Grace Yoon, Severe neurodegeneration, progressive cerebral volume loss and diffuse hypomyelination associated[doi.org] There are generalized polyspike discharges at rest that are exacerbated by photic stimulation. Fig. 3 Axial ( A ) and coronal ( B ) MRI images of individual VI-7.[academic.oup.com]

  • West Syndrome

    Brain magnetic resonance imaging showed diffusely reduced white matter and brainstem volumes with hypomyelination.[ncbi.nlm.nih.gov] Recent study has shown that mutations in the alpha-II-spectrin (SPTAN1) gene cause early onset intractable seizures, severe developmental delay, diffuse hypomyelination, and[ncbi.nlm.nih.gov]

  • Hypomyelinating Leukodystrophy Type 5

    Brain magnetic resonance imaging show the combination of a diffuse hypomyelination with superimposed periventricular white matter signal abnormalities. this study describes[ncbi.nlm.nih.gov] In the intermediate stage (approximately 2–10 years), the white matter is diffusely abnormal with a background of diffuse hypomyelination ( Fig 2 ), in most patients associated[ajnr.org] Neuroimaging studies demonstrated a diffuse supratentorial hypomyelination, with in some patients, additional areas of more prominent signal change in the frontal region.[ncbi.nlm.nih.gov]

    Missing: Polyspike on Photic Stimulation
  • Benign Adult Familial Myoclonic Epilepsy

    Photic stimulation and hyperventilation were performed in all. RESULTS: Nineteen (eight men, 11 women) patients with BAFME were included in this study.[ncbi.nlm.nih.gov] […] wave in burst or isolation  Photic stimulation 40%  Theta rhythm of 5-6Hz in central and vertex 95% 43. 17 m. child with SW induced by opening and closing eyelids Recurrence[slideshare.net] Rare tonic-clonic seizures are also a manifestation and are often precipitated by photic stimulation, emotional stress, and sleep deprivation. • Diagnosis is based on clinical[medlink.com]

    Missing: Diffuse Hypomyelination
  • Juvenile Myoclonic Epilepsy

    Two cases of juvenile myoclonic epilepsy (JME) presented with myoclonic jerks and EEG activation after eye closure, without sensitivity to intermittent photic stimulation.[ncbi.nlm.nih.gov] These discharges may be evoked by photic stimulation (blinking lights) and/or hyperventilation.[en.wikipedia.org] These changes are often induced by photic stimulation (blinking lights) and sometimes hyperventilation.[medindia.net]

    Missing: Diffuse Hypomyelination
  • Generalized Clonic or Tonic-Clonic Seizures

    Specific EEG changes may be seen during photic stimulation. EEG abnormalities are more likely or increased with sleep deprivation and during sleep.[epilepsy.com] Other information is obtained from tests such as: EEG (electroencephalogram) : people with EGTCS have normal EEG background and generalized spike wave or polyspike wave activity[epilepsy.com]

    Missing: Diffuse Hypomyelination
  • Epilepsy

    Contemporary drug therapy fails to control epileptic seizures in some 30% of patients, resulting in the need to employ other measures when they appear practicable. A good deal of potentially relevant statistical detail is available regarding the outcomes of the available antiepileptic therapies, but its interpretation[…][dx.doi.org]

    Missing: Diffuse Hypomyelination
  • Idiopathic Generalized Epilepsy

    These discharges are often precipitated by hyperventilation, sleep deprivation, and intermittent photic stimulation (IPS).[epilepsy.com] EEG shows generalized discharges of spikes, polyspikes, or spike/polyspike-waves either ictally or inter-ictally.[epilepsy.com]

    Missing: Diffuse Hypomyelination
  • Myoclonic-Astatic Epilepsy

    Photic stimulation may trigger generalised spike/wave or myoclonic astatic seizures.[pennsw.com.au] Intermittent photic stimulation may trigger generalized spike-and-wave and polyspike-and-wave, and myoclonic-atonic seizures.[medlink.com] EEG: Usually normal background particularly at onset of syndrome, with frequent generalised discharges of 2 to 3 Hz spike/polyspike wave.[pennsw.com.au]

    Missing: Diffuse Hypomyelination
  • Early Infantile Epileptic Encephalopathy Type 17

    @inproceedings{Kehrl2014GainoffunctionMI, title {Gain-of-function mutation in Gnao1: A murine model of epileptiform encephalopathy (EIEE17)?}, author {Jason M. Kehrl and Kinshuk Sahaya and Hans M. Dalton and Raelene A. Charbeneau and Kevin T. Kohut and Kristen A Gilbert and Madeline C. Pelz and Jack M. Parent and[…][semanticscholar.org]

    Missing: Diffuse Hypomyelination

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