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17 Possible Causes for Diffuse Hypomyelination of the Brain White Matter

  • Hypomyelinating Leukodystrophy Type 5

    Brain magnetic resonance imaging show the combination of a diffuse hypomyelination with superimposed periventricular white matter signal abnormalities. this study describes[ncbi.nlm.nih.gov] MR imaging findings of HCC included diffuse hypomyelination of the supratentorial white matter, in some cases associated with variably extensive areas of increased water content[ajnr.org] […] on both brain MR imaging and nerve biopsy findings in this series.[ajnr.org]

  • West Syndrome

    Brain magnetic resonance imaging showed diffusely reduced white matter and brainstem volumes with hypomyelination.[ncbi.nlm.nih.gov]

  • Central Positional Vertigo

    A repeat brain MRI at 33 months of age confirmed the diffuse hypomyelinating pattern of the supratentorial cerebral white matter ( Figure 1B ).[omicsonline.org]

  • Congenital Cataract

    Brain magnetic resonance imaging show the combination of a diffuse hypomyelination with superimposed periventricular white matter signal abnormalities.[ncbi.nlm.nih.gov] MR imaging findings of HCC included diffuse hypomyelination of the supratentorial white matter, in some cases associated with variably extensive areas of increased water content[ajnr.org] […] on both brain MR imaging and nerve biopsy findings in this series.[ajnr.org]

  • Pelizaeus-Merzbacher Disease

    Figure 1: T1- (a) and T2 (b and c)-weighted axial MR images of the brain show diffuse hypomyelination of white matter appearing isointense on T1-weighted images and hyperintense[annalsofian.org] A repeat brain MRI at 33 months of age confirmed the diffuse hypomyelinating pattern of the supratentorial cerebral white matter ( Figure 1B ).[omicsonline.org]

  • Autosomal Recessive Congenital Cataract 5

    MR imaging findings of HCC included diffuse hypomyelination of the supratentorial white matter, in some cases associated with variably extensive areas of increased water content[ajnr.org] […] on both brain MR imaging and nerve biopsy findings in this series.[ajnr.org] […] appears to play an important, albeit as yet undetermined, role in the process of myelination of both central and peripheral nervous systems, as indicated by evidence of hypomyelination[ajnr.org]

  • Cockayne Syndrome

    Brain imaging reveals diffuse hypomyelination of the cerebral white matter, calcifications in the putamen, and vermian atrophy.[orpha.net] OBJECTIVE: Cockayne syndrome (CS) is a rare disorder characterized by severe brain atrophy, white matter (WM) hypomyelination and basal ganglia calcifications.[ncbi.nlm.nih.gov] This study aimed to quantify atrophy and WM abnormalities using diffusion tensor imaging (DTI) and volumetric analysis, to evaluate possible differences between CS subtypes[ncbi.nlm.nih.gov]

  • X-Linked Spastic Paraplegia Type 2

    White matter N-acetyl aspartate levels are reduced. Brain magnetic resonance imaging (MRI) reveals patchy or diffuse hypomyelination on T2-weighted images.[rarediseases.info.nih.gov]

  • Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

    Childhood Ataxia with diffuse Central Nervous System Hypomyelination Disease (CACH/VWM) is progressive inherited disorder that mainly affects the brain and spinal cord (central[australasianleukodystrophyfoundation.com] This disorder causes deterioration of the central nervous system’s white matter, which is known as Myelin.[australasianleukodystrophyfoundation.com]

  • Xeroderma Pigmentosum-Cockayne Syndrome Complex

    Brain imaging reveals diffuse hypomyelination of the cerebral white matter, calcifications in the putamen, and vermian atrophy.[checkorphan.org]

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