Possible Causes for dilated collecting tubules Medullary Sponge Kidney Medullary sponge kidney is a disorder in which dilated collecting tubules (1 to 7.5 mm in diameter) are found in one or more renal papillae. 1 In the absence of complications [nejm.org] […] urography suggested a diagnosis of polycystic renal disease (PRD); but the linear and cystic dilatation of collecting tubules, many of which contained numerous calculi, was [ncbi.nlm.nih.gov] In this case the dilatations of collecting tubules and intra- and extrahepatic bile ducts were observed. [ncbi.nlm.nih.gov] Renal Function Impairment This observation could explain the dilated proximal tubules that are observed upon renal biopsy of ARF kidneys, even though GFR is less than 10% of normal. [jci.org] In fact, microdissection of individual nephrons of kidneys from patients with ARF demonstrated obstructing casts in distal tubules and collecting ducts ( 42 ). [jci.org] Acute Renal Failure This observation could explain the dilated proximal tubules that are observed upon renal biopsy of ARF kidneys, even though GFR is less than 10% of normal. [doi.org] In fact, microdissection of individual nephrons of kidneys from patients with ARF demonstrated obstructing casts in distal tubules and collecting ducts ( 42 ). [doi.org] Duodenal Diverticulum […] portion repeatedly divides and forms the pelvis, the renal calyces, the channels and the collecting tubules of the definitive kidney [36]. [cureus.com] […] of the Wolffian duct, the ureteric bud (near the cloaca) surrounded by metanephric tissue; the proximal part of this diverticulum represents the future ureter while the dilated [cureus.com] Renal Colic MSK is generally a benign congenital condition that demonstrates dilation of the distal renal collecting tubules on IVP as the tubules fill with contrast. [web.archive.org] Nephrolithiasis […] that demonstrates dilation of the distal renal collecting tubules on IVP as the tubules fill with contrast. [emedicine.medscape.com] Medullary sponge kidney Medullary sponge kidney (MSK), also called tubular or ductal ectasia or cystic dilation of the collecting ducts, is a generally benign congenital condition [emedicine.medscape.com] Urolithiasis Multiple pyramidal calculi may indicate the presence of medullary sponge kidney, a disease of unknown cause that results in dilatation of distal collecting tubules within [ajronline.org] Uremic Pneumonitis […] of collecting tubule origin and cuboidal epithelium Relatively common cystic disease in adults, often an incidental finding, normal renal function complications: calcification [studyblue.com] infection, stones See cystically dilated papillary ducts and cuboidal or transitional epithelial lining Sporadic (non-familial) -20% Familial juvenile nephronophthisis - [studyblue.com] […] duct proliferation infantile and juvenile forms also have congenital hepatic fibrosis numerous small cysts in cortex and medulla Microscopically see saccular to cylindrical dilation [studyblue.com] Acute Renal Injury This observation could explain the dilated proximal tubules that are observed upon renal biopsy of ARF kidneys, even though GFR is less than 10% of normal. [jci.org] In fact, microdissection of individual nephrons of kidneys from patients with ARF demonstrated obstructing casts in distal tubules and collecting ducts ( 42 ). [jci.org] Renal Pelvic Calculus It results from a malformation of collecting tubules producing dilation and multiple cysts. [emedicine.medscape.com] Pathologically, the kidney has innumerable small cysts that represent dilation of the collecting tubules. [emedicine.medscape.com] Epididymal cysts, or spermatoceles, are a cystic dilation of the tubules of the efferent ductules or aberrant ducts of the epididymis. [emedicine.medscape.com] Staghorn Calculus Multiple pyramidal calculi may indicate the presence of medullary sponge kidney, a disease of unknown cause that results in dilatation of distal collecting tubules within [docplayer.info] Acute Interstitial Nephritis • The earliest lesion is a focal degenerative change in renal epithelia, primarily in collecting ducts, distal convoluted tubules, and loops of Henle. • Tubule cell necrosis [slideshare.net] […] leads to nephron obstruction and stasis of intrarenal urine, favoring local precipitation of calcium salts and infection. • Dilatation and atrophy of tubules eventually occur [slideshare.net] Hydronephrosis The collecting tubules dilate and the muscular walls of the pelvis and calices stretch, are replaced by fibrous tissue, and eventually form a large, fluid-filled, functionless [medical-dictionary.thefreedictionary.com] The collecting tubules dilate and the muscular walls of the renal pelvis and calices stretch, are replaced by fibrous tissue, and eventually form a large, fluid-filled, functionless [medical-dictionary.thefreedictionary.com] Congenital Hepatic Fibrosis [b] In congenital hepatic fibrosis, dilatation of the collecting tubules is considered as the most common associated renal lesion (1). Multiple FULL TEXT [annals.org] A similar mechanism might explain the dilatation of the renal collecting tubules. [kjim.org] That is, an identical insult at different loci may result in choledochal cyst, dilatations of the major intrahepatic bile ducts (Caroli’s disease), congenital hepatic fibrosis [kjim.org] Urate Kidney Stone […] of the collecting tubules of the medullary portion of the renal pyramids give the organ a spongy, porous feeling and appearance. [medical-dictionary.thefreedictionary.com] […] band of tissue as a result of fusion of the poles of the renal anlagen. medullary sponge kidney a usually asymptomatic congenital condition in which multiple small cystic dilatations [medical-dictionary.thefreedictionary.com] Congenital Urethral Stricture There is cystic dilatation of the collecting tubules in one or both kidneys. Nephrocalcinosis and recurrent renal stones are usually seen. [patient.info] Nephrocalcinosis Medullary sponge kidney is a developmental anomaly characterized by cystic dilatation of the collecting tubules in one or more renal medullary pyramids. [sonoworld.com] Medullary Sponge Kiney Ectatic dilatation of the distal collecting tubules confined to the renal pyramids Not exactly a true NC as the calcium deposition lies in the dilated [slideshare.net] The intraluminal deposits in such tubules appeared to be obstructing a number of the inner medullary collecting ducts, as evidenced by dilatation of these tubules at and proximal [doi.org] Nonallergic Interstitial Nephritis […] proximal tubules with thinning or loss of PAS brush border; hyaline, granular and pigmented cases, particularly in distal and collecting ducts, eosinophilic hyaline casts [pathologyoutlines.com] Microscopic (histologic) description Ischemic ATN: Early: varies from cell swelling to focal tubular epithelial necrosis and apoptosis with desquamation of cells into lumen; dilated [pathologyoutlines.com] Rhabdomyolysis This observation could explain the dilated proximal tubules that are observed upon renal biopsy of ARF kidneys, even though GFR is less than 10% of normal. [doi.org] In fact, microdissection of individual nephrons of kidneys from patients with ARF demonstrated obstructing casts in distal tubules and collecting ducts ( 42 ). [doi.org] Interstitial Nephritis • The earliest lesion is a focal degenerative change in renal epithelia, primarily in collecting ducts, distal convoluted tubules, and loops of Henle. • Tubule cell necrosis [slideshare.net] […] leads to nephron obstruction and stasis of intrarenal urine, favoring local precipitation of calcium salts and infection. • Dilatation and atrophy of tubules eventually occur [slideshare.net] Cystic Kidney Autosomal Recessive Polycystic Kidney Disease (ARPKD) ARPKD, a heritable condition, is characterized by cystic dilations of the renal collecting tubules. [hawaii.edu] collecting ducts (Figure 9). 41,44 MSK has an excellent long term prognosis; however complications of recurrent urinary tract obstruction and infections may cause progressive [appliedradiology.com] 1,43 On unenhanced CT, the presence of medullary nephrocalcinosis is commonly identified and CT urography demonstrates ‘papillary brush’ morphology and stones within the dilated [appliedradiology.com] Hypercalcemic Nephropathy Medullary Sponge Kiney Ectatic dilatation of the distal collecting tubules confined to the renal pyramids Not exactly a true NC as the calcium deposition lies in the dilated [slideshare.net] The intraluminal deposits in such tubules appeared to be obstructing a number of the inner medullary collecting ducts, as evidenced by dilatation of these tubules at and proximal [doi.org] Many of these upstream dilated collecting ducts contained cast material and were lined by damaged cells. [doi.org] Solitary Renal Cyst Autosomal Recessive Polycystic Kidney Disease (ARPKD) ARPKD, a heritable condition, is characterized by cystic dilations of the renal collecting tubules. [hawaii.edu] Microscopically, the cysts are lined by flattened (undifferentiated) epithelium and represent fusiform dilation of collecting tubules that retain their connection to the afferent [homeopathyworldcommunity.ning.com] Microscopic evaluation shows cystic dilatations in all segments of the nephron, with loss of connection to the tubule. [homeopathyworldcommunity.ning.com] Urinary Tract Obstruction Obstructions at this level cause dilation of the collecting tubules of the kidney. This is called hydronephrosis. [childrens.memorialhermann.org] Uric acid crystals Pathologic findings consist of dilation of the collecting ducts and distal tubules and chronic tubular atrophy with little glomerular damage. [msdmanuals.com] Dilation takes 3 days from the onset of obstructive uropathy to develop; before then, the collecting system is relatively noncompliant and less likely to dilate. [msdmanuals.com] Polycystic Kidney Disease These corresponded pathologically to radially oriented, dilated collecting tubules. Autosomal recessive polycystic kidney disease (ARPKD). [emedicine.com] Image C Image D Histology: Cystic dilatation of terminal ends of ampullary collecting ducts, proximal convoluted tubules, and Bowman's capsule ( glomerular or tubular cysts [auanet.org] Familial Hypospadias There is cystic dilatation of the collecting tubules in one or both kidneys. Nephrocalcinosis and recurrent renal stones are usually seen. [patient.info] Distal Renal Tubular Acidosis Medullary sponge kidney (MSK) is a rare congenital disease characterized by diffuse ectasia or dilation of precalyceal collecting tubules. [ncbi.nlm.nih.gov] Bilateral Renal Dysplasia […] of the collecting tubules. [cags.org.ae] There is cystic dilatation of the collecting tubules in one or both kidneys. Nephrocalcinosis and recurrent renal stones are usually seen. [patient.info] […] urinary system Mode of Inheritance Autosomal dominant Gene Map Locus Multicystic renal dysplasia is a congenital dysplasia of the kidney characterized by large nonhomogeneous dilations [cags.org.ae] Recombinant Chromosome 8 Syndrome Description Recombinant 8 syndrome is a condition that involves heart and urinary tract abnormalities, moderate to severe intellectual disability, and a distinctive facial appearance. The characteristic facial features include a wide, square face; a thin upper lip; a downturned mouth; a small chin (micrognathia);[…] [medlineplus.gov] Benign Polyp of the Ureter […] of the collecting tubules. 10(p40) Patients are frequently asymptomatic, but may have microhematuria. [appliedradiology.com] Classically described as having a “paint brush” appearance, contrast opacifies the dilated tubules, resulting in dense striations extending from the papillary tips into the [appliedradiology.com] […] more papillae, or caliceal-filling defects from sloughed papillae (Figure 1). 10(p89,p151),11(pt3,sec3,p46) Renal tubular ectasia is characterized by noncalcified cystic dilatation [appliedradiology.com]
