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16 Possible Causes for dimethylallyl, synthetase, tryptophan

  • Novobiocin

    The 3-dimethylallyl-4-hydroxybenzoic acid moiety, known as ring A, is derived from prephenate and dimethylallyl pyrophosphate .[] As in mycF and tylF , the glycine at position 7 in novP is replaced by a tryptophan. Fig. 3.[] We have purified the major yeast novobiocin binding proteins and identified one of them as the beta-subunit of the yeast mitochondrial F1 ATP synthetase, a protein highly[]

  • Ergot Alkaloid

    Biosynthesis Biosynthesis of Lysergic Acid The lysergic acid is synthesized from tryptophan and dimethylallyl pyrophosphate (see biosynthesis of terpenes ).[] The synthesis of clavine alkaloids, lysergic acid derivatives, the use of tryptophan as the starting material, the chemistry of 1,3,4,5-tetrahydrobenzo[cd]indoles, and the[] Recently, D-lysergyl peptide synthetase (LPS) of the ergot fungus Claviceps purpurea, which assembles the non-cyclol precursors of the ergopeptines, has been partially purified[]

  • Cystoid Macular Dystrophy

    Ionization of DMAPP generates a dimethylallyl carbocation, and deprotonation of the indole nitrogen accompanies or precedes the nucleophilic attack.[] […] macular edema posing a diagnostic and therapeutic dilemma. ( 29780921 ) Patel S.R....Rodger D.C. 2018 3 Treatment of cystoid macular edema in homozygous twins with glutathione synthetase[] […] cyclomarin/cyclomarazine prenyltransferase CymD revealed its ability to prenylate tryptophan prior to incorporation into both cyclic peptides by the nonribosomal peptide synthetase[]

  • X-Linked Intellectual Disability - Spastic Quadriparesis Syndrome

    Condensation of IPP with an additional activated isoprene, dimethylallyl diphosphate, yields geranyl diphosphate, which is further metabolized to farnesyl diphosphate and[] Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy .[] Brigham and M.Cogley, Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan. J.Biol.Chem. 269 (1994) 212–216.[]

  • Ergotamine

    Its biosynthesis in these fungi requires the amino acid L-tryptophan and dimethylallyl diphosphate.[] The early pathway, shared among these fungi, begins with the action of an aromatic prenyl transferase, DMATrp synthase, which links a dimethylallyl chain to L-tryptophan.[] […] of L-tryptophan.[]

  • Cortical Blindness-Intellectual Disability-Polydactyly Syndrome

    Condensation of IPP with an additional activated isoprene, dimethylallyl diphosphate, yields geranyl diphosphate, which is further metabolized to farnesyl diphosphate and[] Aldosterone-Producing Adenoma With Seizures And Neurological Abnormalities Alpha-N-Acetylgalactosaminidase Deficiency Type 1 Amish Infantile Epilepsy Syndrome Asparagine Synthetase[] Hemophagocytic Lymphohistiocytosis , Familial, 1 Hemophagocytic Lymphohistiocytosis , Familial, 2 Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome Holocarboxylase Synthetase[]

  • Carotenoid

    […] pathway leading to the synthesis of carotenoids is described as the three following principal steps: (i) the synthesis of isopentenyl pyrophosphate and the formation of dimethylallyl[] The percent apparent retention in boiled fresh maize was 92%, 117%, 99%, and 66% for PVA, zinc, lysine, and tryptophan, respectively.[] […] endometrial and colon cell proliferation garlic can lower blood cholesterol nearly 10% in high-cholesterol plants garlic can lower blood pressure garlic can induce nitric oxide synthetase[]

  • Mycobacterium Leprae

    The precursors of all mycobacterial polyprenyl-Ps, isopentenyl-P-P (IPP) and dimethylallyl-P-P (DMAPP), are generated by the non-mevalonate deoxylulose-5-P (DXP) pathway [[] Among them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent the greatest upregulation and was also shown to be upregulated in M. leprae-infected human[] We report here that 4 B cell epitopes of myelin A1 and Mycobacterium leprae proteins, 50S ribosomal L2 and lysyl tRNA synthetase are cross-reactive.[]

  • Micrococcus Luteus

    […] exposure to small phosphoruscontaining antigens in the family of prenyl pyrophosphates and their related biosynthetic precursors such as isopentenyl pyrophosphate (IPP) and dimethylallyl[] […] metabolism 00400 Phenylalanine, tyrosine and tryptophan biosynthesis Metabolism of other amino acids 00410 beta-Alanine metabolism 00430 Taurine and hypotaurine metabolism[] Although an ectoine synthetase gene is annotated (Mlut_02920), the remainder of the operon required for production of this molecule is apparently absent.[]

  • Salmonella Paratyphi A

    (miaA) Gene Names: miaA ; DMAPP:tRNA dimethylallyltransferase; DMATase; IPP transferase; IPPT; IPTase Other Names: tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA; Dimethylallyl[] TDA Tryptophan deaminase - - - - 31. TO4 Tobramycin - - - 32. URE Urea - - - - 33.[] […] or Yeast or Baculovirus or Mammalian Cell Recombinant Salmonella paratyphi B Methionine--tRNA ligase (metG), partial Other Names: methionine--tRNA ligase; Methionyl-tRNA synthetase[]