Direct Bilirubin Increased: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Direct Bilirubin Increased

Rotor Syndrome

This is similar to Dubin-Johnson syndrome and both leads to increase conjugated (direct) bilirubin. [labpedia.net]

Laboratory findings showed increased serum bilirubin with direct bilirubin predominance. The urinary excretion of total coproporphyrin was slightly elevated. [kjp.or.kr]

Liver function tests are shown below: ALT 26 U/L AST 29 U/L Alkaline Phosphatase 138 U/L Bilirubin, Total 8 mg/dL Bilirubin, Direct 7.5 mg/dL A urine analysis shows a normal [usmleforum.com]

Intrahepatic Cholestasis

Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels. [smfm.org]

[…] of direct bilirubin relative to total bilirubin concentration. [ncbi.nlm.nih.gov]

An increase in the frequency of MSAF was also associated with higher serum levels at diagnosis of alanine transaminase, alkaline phosphatase and direct bilirubin. [ncbi.nlm.nih.gov]

Secondary Biliary Cirrhosis

The physician obtains liver function tests which demonstrate an increased direct bilirubin and an increased alkaline phosphatase. [medbullets.com]

Dubin-Johnson Syndrome

Dubin-Johnson syndrome should be considered when the common causes for conjugated hyperbilirubinaemia have been excluded, and patient has an increased percentage of direct [ncbi.nlm.nih.gov]

[…] of direct bilirubin relative to total bilirubin concentration. [hal.inserm.fr]

A blood sample showed increased acute phase reactants, leukocytosis, neutrophilia and increased bilirubin levels (total 6.74 mg/dl, direct 6.21 mg/dl). [scielo.isciii.es]

Biliary Atresia

We evaluated the clinical impact and cost of reflex testing in infants with increased direct bilirubin (>1.5 mg/dL; >25 μmol/L). [ncbi.nlm.nih.gov]

Because of an increasing direct bilirubin level and the absence of bile excretion, a laparotomy was performed at the age of 29 days. [ncbi.nlm.nih.gov]

341 IU/L) increased the total bilirubin, direct bilirubin, and γ -GT in all patients of both groups and increased alkaline phosphatase in three patients of group A and ten [e-ultrasonography.org]

Cholestasis

Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels. [smfm.org]

AST and ALT may be increased 2 - 20 fold. Total and direct bilirubin may also be significantly elevated. [clinicaladvisor.com]

AST and ALT may be increased 2 – 20 fold. Total and direct bilirubin may also be significantly elevated. [cancertherapyadvisor.com]

Choledocholithiasis

Still, the most statistically significant and useful predictor found in our study was a ratio of direct bilirubin to total bilirubin greater than 30%. [scielo.org.co]

bilirubin to total bilirubin ratios greater than 30%. [scielo.org.co]

The presence of this predictor increased the probability of choledocholithiasis by 9.25 times (95% CI 1.20 to 65.69) and increased the probability of common bile duct dilation [scielo.org.co]

Progressive Familial Intrahepatic Cholestasis

During the hospital admission the direct bilirubin increased to 8.2 mg/dL out of a total of 10.4 mg/dL. [scielo.org.mx]

While evaluating a jaundiced infant, the initial step is measuring the serum total (TB) and direct bilirubin. [dovepress.com]

In PFICs, laboratory abnormalities include increased serum alkaline phosphatase (ALP), variable elevation of bilirubin, decreased/increased gamma-glutamyltransferase (GGT) [dovepress.com]

Extrahepatic Cholestasis

An increase in urinary bilirubin is nearly always indicative of a corresponding increase in the serum direct fraction attributable to intrahepatic or extrahepatic cholestasis [medical-dictionary.thefreedictionary.com]

Liver Failure

These findings translated to tests of upscaled adsorbents in a dynamic model for liver failure: upscaled Hepalbin adsorbent removes bile acids, direct bilirubin and indirect [ncbi.nlm.nih.gov]

– measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated (combined with [labtestsonline.org]

[…] bilirubin significantly better than MARS adsorbents and significantly increases ABiC. [ncbi.nlm.nih.gov]

Massive Hepatic Necrosis

Early - features of cholangiohepatitis and cholestasis (increased ALP, AST, direct bilirubin, cholesterol); hepatomegaly, jaundice, and pruritis (destructive phase) Late - [quizlet.com]

[…] mg/dL Increased Increased Increased Increased Urine bilirubin None Increased Increased Serum albumin/ total protein Alb, 3.5-5.5 g/dL Tot, 6.5-8.4 g/dL Albumin decreased [slideshare.net]

Symptoms related to etiology Cholestasis symptoms (increased ALP, direct bilirubin, cholesterol; hepatomegaly, janduice, pruritis) Symptoms of secondary infection (frequent [quizlet.com]

Cryptogenic Cirrhosis

This is mainly directed at evaluating the presence of increased liver enzymes (alanine aminotrans-ferase, aspartate aminotransferase, alkaline phosphatase, and gamma glutamyl [elsevier.es]

[…] transferase), the integrity of the hepatic functions (e.g. prothrombin time, bilirubin, and albumin), as well as liver stiffness measurement as a surrogate for liver fibrosis [elsevier.es]

Paroxysmal Cold Hemoglobinuria

Total bilirubin is only modestly increased (up to 5 mg/dL) and, with rare exceptions, the conjugated (direct) fraction constitutes less than 15 percent of the total. [errolozdalga.com]

[…] indirect bilirubin level A positive direct antiglobulin test with a broad-spectrum antibody against immunoglobulin and complement. [omicsonline.org]

In addition to the usual findings associated with hemolytic anemia (RBC polychromasia, increased unconjugated bilirubin, Decreased haptoglobin, and hemoglobinuria) there is [med-ed.virginia.edu]

Acute Cholecystitis

In the uncomplicated cholecystitis, usually there are no increase of serum total and direct bilirubin and alkaline phosphatase (cholestasis indexes). [intechopen.com]

Viral Hepatitis

The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity [academic.oup.com]

Serum ALT is usually increased more than serum aspartate aminotransferase. [academic.oup.com]

Giant Cell Hepatitis

However, bilirubin again increased to 13.2 mg/dl at 5 months of age in spite of HSV IgG. [mjdrdypu.org]

He developed increasing jaundice with a total bilirubin of 36 mg/dl and a direct bilirubin of 28 mg/dl, AST 169 U and ALT 88 U. [medicine.tamu.edu]

She was started on acyclovir (80 mg/kg/day) at 2½ months of age in view of 4 fold rise in HSV immunoglobulin G (IgG) following which her bilirubin decreased to 8 mg/dl (direct [mjdrdypu.org]

Acute Fatty Liver of Pregnancy

[…] levels were 4.97 mg% (direct) and 6.63 mg% (indirect). [doi.org]

There were moderately increased blood levels of urea and creatinine but a pronounced increase of uric acid (13.4 mg%). [doi.org]

Twenty‐four hours after delivery the urinary output was 1.2 l/day and laboratory tests showed a minimal proteinuria, pronounced anaemia but with a normal platelet count and bilirubin [doi.org]

Hepatitis A

The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity [clinchem.org]

Serum ALT is usually increased more than serum aspartate aminotransferase. [clinchem.org]

Fascioliasis

However, the value of ALP, alpha-amylase and direct bilirubin increased (135 U/L, 185 U/L and 6.0 μM/L; the normal value is 35–130 U/L, 72–182 U/L and Based on routine, the [parasitol.kr]

BIL, while a slight increase of direct BIL was observed in 45% of the patients. [journals.plos.org]

However, another two indicators, i.e. bilirubin (BIL) and total bile acid (TBA), did not support this diagnosis as almost all patients showed normal total BIL and indirect [journals.plos.org]

Hepatic Veno-Occlusive Disease

The total bilirubin (TBIL) level gradually increased to 70 mmol/l and the direct bilirubin (DBIL) level gradually increased to 50 mmol/l, both of which were outside the normal [spandidos-publications.com]

[…] in abdominal circumference, hepatomegaly, right upper quadrant pain, ascites, and elevated total and direct bilirubin levels. [emedicine.medscape.com]

Macrophage-activating syndromes (eg, hemophagocytic lymphohistiocytosis, Griscelli syndrome) Physical The clinical symptoms of veno-occlusive disease include weight gain, an increase [emedicine.medscape.com]

Cholelithiasis

OBJECTIVE: The aim of this study was to examine the etiology of gallstones in children and responses to ursodeoxycholic acid (UDCA) treatment. METHODS: 74 children with cholelithiasis were recruited, and underwent ultrasonography to detect gallstones. All relevant clinical information was recorded in a structured[…] [ncbi.nlm.nih.gov]

Toxoplasmosis

Toxoplasmosis is an infectious disease caused by the protozoan Toxoplasma gondii. In an immunocompetent host, infection is generally asymptomatic, but toxoplasmosis in pregnancy can cause birth defects. Asymptomatic lymphadenopathy is the most usual presentation. The main lymph nodes involved are cervical and[…] [symptoma.com]

Hemochromatosis

Hemochromatosis is the abnormal accumulation of iron in parenchymal organs and the most common form of iron overload disease. It may be inherited or acquired. The patients suffering from hemochromatosis have the following clinical picture. The skin of these patients acquires a bronze pigmentation due to the[…] [symptoma.com]

Portal Cirrhosis

Laennec's cirrhosis Specialty Gastroenterology Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis,[1] is named after René Laennec,[2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture[…] [en.wikipedia.org]

Acute Pancreatitis

Abstract In this study we determined the clinical accuracy of α 2 - macroglobulin, α-amylase, C-reactive protein, lipase, non-esterified fatty acids, pancreatic α-amylase and phospholipase A in the diagnosis and prognosis of acute pancreatitis in a group of patients with acute abdominal pain using receiver operator[…] [doi.org]

Macronodular Cirrhosis

Hepatocellular carcinoma is rare in infancy. This report describes the first documented case of congenital hepatocellular carcinoma associated with macronodular cirrhosis. [ncbi.nlm.nih.gov]

Bile Duct Stricture

Abstract Patients with recurrent high bile duct strictures pose special problems for management. Relief of obstruction by hepaticojejunostomy is usually possible but the standard technique does not permit long term access. Six patients with benign strictures involving hepatic ducts have been treated by a simple[…] [ncbi.nlm.nih.gov]

Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. History A concise and complete history-taking should be done by the physician to obtain valuable pieces of information such as occupation, a history of hepatitis, jaundice, intravenous drug use, blood transfusion, multiple unprotected[…] [symptoma.com]

Ascending Cholangitis

Abstract An intussusception-type antireflux valve was created in the Roux-en-Y loop in 23 infants with biliary atresia (17 new cases, and six others after episodes of ascending cholangitis) and 10 patients with congenital bile duct dilatation, in order to prevent ascending cholangitis after hepatic portojejunostomy.[…] [ncbi.nlm.nih.gov]

Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by fibrosis and inflammation of intra- and extrahepatic biliary ducts. The course of the disease varies from person to person, and may lead to liver cirrhosis and associated complications. The course of the disease[…] [symptoma.com]