Create issue ticket

25 Possible Causes for Direct Bilirubin Increased, Incidence of Hepatocellular Carcinoma Increased

  • Cholelithiasis

    The incidence of ICC is relatively low but increasing worldwide [ 4, 5 ]. The risk factors for ICC are complex.[bmccancer.biomedcentral.com] ICC, the second most frequent liver neoplasm following hepatocellular carcinoma, is highly malignant and shows extremely poor prognosis [ 3 ].[bmccancer.biomedcentral.com]

  • Hepatocellular Carcinoma

    The incidence of hepatocellular carcinoma increased with serum HBV DNA level at study entry in a dose-response relationship ranging from 108 per 100,000 person-years for an[ncbi.nlm.nih.gov] The incidence of hepatocellular carcinoma (HCC) is increasing in western countries.[ncbi.nlm.nih.gov] There was an increasing trend of cumulative hepatocellular carcinoma incidence with increasing serum HBV DNA level at study entry examination for all participants.[doi.org]

  • Hemochromatosis

    Approximately 6 percent of patients with hereditary hemochromatosis and cirrhosis develop hepatocellular carcinoma; this represents a 20-fold increased lifetime risk over[aafp.org] C 14, 20 AASLD and IDI vary* Hereditary hemochromatosis is associated with malignancies, particularly hepatocellular carcinoma.[aafp.org] […] the general population and a 4 percent annual incidence rate. 3 The mechanism for increased risk is the effect of excess iron in promoting oxidative DNA damage and free radical[aafp.org]

  • Cholestasis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] AST and ALT may be increased 2 - 20 fold. Total and direct bilirubin may also be significantly elevated.[clinicaladvisor.com]

  • Macronodular Cirrhosis

    Pearls and Other Issues Hepatocellular Carcinoma HCC is the most common primary cancer in the liver, and its incidence is increasing [33].[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    PURPOSE: Liver cancer (hepatocellular carcinoma (HCC)) incidence and mortality rates are increasing in the United States.[ncbi.nlm.nih.gov]

  • Primary Sclerosing Cholangitis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] In this setting, the estimated incidence of the development of hepatocellular carcinoma is 1% to 4% per year. 34 Cirrhosis from causes other than hepatitis C, particularly[clevelandclinicmeded.com]

  • Gallbladder Carcinoma

    The association of a hepatocellular carcinoma and gallbladder adenocarcinoma is extremely rare.[ncbi.nlm.nih.gov] This association, together with an analysis of the literature showing the increased incidence of gallstones in cirrhotic patients and the consequent greater surgical risk[ncbi.nlm.nih.gov] carcinoma or cirrhosis, even for minor resections and when there are no evident signs of gallbladder disease.[ncbi.nlm.nih.gov]

  • Fatty Liver

    Microbiome and Liver Cancer The incidence of hepatocellular carcinoma (HCC) is increased with the progression of NAFLD to advanced cirrhosis and may be mediated through changes[doi.org] Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123, 134–140 (2002). 119.[doi.org] The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51, 1972–1978 (2010). 58. Dulai, P. S. et al.[doi.org]

  • Intrahepatic Cholestasis

    Hepatocellular carcinoma, once a relatively uncommon tumor, has been increasing in incidence since the 1990s because of its association with hepatitis C–induced cirrhosis.[clevelandclinicmeded.com] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] […] of direct bilirubin relative to total bilirubin concentration.[ncbi.nlm.nih.gov]

Further symptoms