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10 Possible Causes for Direct Bilirubin Increased, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Early - features of cholangiohepatitis and cholestasis (increased ALP, AST, direct bilirubin, cholesterol); hepatomegaly, jaundice, and pruritis (destructive phase) Late -[quizlet.com] […] mg/dL Increased Increased Increased Increased Urine bilirubin None Increased Increased Serum albumin/ total protein Alb, 3.5-5.5 g/dL Tot, 6.5-8.4 g/dL Albumin decreased[slideshare.net]

  • Primary Sclerosing Cholangitis

    Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibro-obliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma. Despite clinical[…][ncbi.nlm.nih.gov]

  • Viral Hepatitis

    Abstract The commonest causes of acute pancreatitis are cholelithiasis and alcohol. Rare causes include various viral infections, among which mumps is the commonest. Hepatitis A, hepatitis B and, recently, hepatitis E have been reported to cause acute but mild pancreatitis in patients with acute viral hepatitis. This[…][ncbi.nlm.nih.gov]

  • Isoniazid Hepatitis

    Abstract On request of local health officials, the authors investigated isoniazid (INH) hepatitis morbidity and mortality among patients attending an Hispanic prenatal clinic. Among 3,681 women treated with INH during and after pregnancy to prevent tuberculosis (TB), 5 developed INH hepatitis, and 2 of the 5 women[…][ncbi.nlm.nih.gov]

  • Hepatitis A

    The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity[clinchem.org] Serum ALT is usually increased more than serum aspartate aminotransferase.[clinchem.org]

  • Hepatitis B

    Hepatitis B is a form of viral hepatitis, caused by the hepatitis B virus, a member of the Hepadnavirus family. It is estimated that worldwide, more than 350 million people have chronic hepatitis B virus infection. The course of the disease may be extremely variable, depending on the patient’s age and immune status.[…][symptoma.com]

  • Aflatoxicosis

    Abstract A 3-month double-blind and placebo-controlled, phase IIa clinical trial was conducted in Ghana to investigate the safety, tolerance and aflatoxin-sorption efficacy of dietary NovaSil (NS). Volunteers (507 subjects) were clinically screened to evaluate their general health, pregnancy status and blood[…][ncbi.nlm.nih.gov]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov]

  • Mitochondrial DNA Depletion Syndrome 3 Type Hepatocerebral

    […] function tests; Liver tissue shows 80 to 99% depletion of mitochondrial DNA (mtDNA) with decreased activities of mitochondrial-encoded respiratory chain complexes; Biopsy[genome.jp] direct bilirubin and prolonged clotting times.[elsevier.es] […] shows micronodular cirrhosis; Cholestasis; Steatosis; Jaundice; Hepatocellular loss; Hepatocellular necrosis; Periportal fibrosis; Pseudoacinar formation; Electron microscopy[genome.jp]

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