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44 Possible Causes for Direct Bilirubin Increased, Liver Firm

  • Cryptogenic Cirrhosis

    CARDIAC CIRRHOSIS Clinic a l featu r es · Mild jaundice · Liver dysfunction · Hepatomegaly – firm, non tender • *Ascites · Peripheral edema · Oesophageal bleeding · Encephalopathy[medicscientist.com] The liver is typically palpable and firm, with a blunt edge, but is sometimes small and difficult to palpate. Nodules usually are not palpable.[merckmanuals.com] Clinical signs that suggest a chronic liver disorder or chronic alcohol use but are not specific for cirrhosis include muscle wasting, palmar erythema, parotid gland enlargement[merckmanuals.com]

  • Macronodular Cirrhosis

    A physician can sometimes identify early stages of cirrhosis by gently pressing the abdomen to determine whether the liver is enlarged and firm.[nmihi.com] During later stages of the disease the liver shrinks, causing an enlarged spleen which a physician may also identify by gently touching the abdomen.[nmihi.com]

  • Portal Cirrhosis

    Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis, is named after René Laennec, a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture is lost, with fibrosis (scarring) and later nodular[…][en.wikipedia.org]

  • Primary Biliary Cirrhosis

    During the physical examination, the doctor may feel an enlarged, firm liver (in about 25% of people) or an enlarged spleen (in about 15%).[merckmanuals.com] Other initial manifestations include right upper quadrant discomfort (10%); an enlarged, firm, nontender liver (25%); splenomegaly (15%); hyperpigmentation (25%); xanthelasmas[merckmanuals.com] Liver transplantation remains the only option for end-stage disease but recurrence of disease may be found in the graft.[ncbi.nlm.nih.gov]

  • Secondary Biliary Cirrhosis

    This is followed by ductopenia, liver cell necrosis & cirrhosis.[gen9mdforum.forumegypt.net] The physician obtains liver function tests which demonstrate an increased direct bilirubin and an increased alkaline phosphatase.[medbullets.com] Gross Size : enlarged Consistency : firm due to fibrosis Surface & cut section : micronodular cirrhosis Colour : green bile stained Size : enlarged Consistency : firm due[gen9mdforum.forumegypt.net]

  • Metastatic Liver Carcinoma

    BACKGROUND: Noninvasive imaging techniques, such as dynamic computed tomography (CT), magnetic resonance imaging and transabdominal ultrasonography are limited in their ability to detect hepatic lesions less than one cm. Intraoperative ultrasonography (IOUS) is currently the most sensitive modality for the detection[…][ncbi.nlm.nih.gov]

  • Wilson Disease

    Progressive hepatolenticular degeneration, or Wilson's disease, is a genetic disorder of copper metabolism. Knowledge of the clinical presentations and treatment of the disease are important both to the generalist and to specialists in gastroenterology and hepatology, neurology, psychiatry, and paediatrics. Wilson's[…][ncbi.nlm.nih.gov]

  • Toxoplasmosis

    The lymph nodes are generally firm, discrete and are usually multiple. Enlarged spleen or liver may be palpable. Patient may be febrile and may appear weak.[symptoma.com]

  • Hemochromatosis

    Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic). This is a low-power micrograph of liver from this patient.[peir.path.uab.edu] This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown.[peir.path.uab.edu] The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.[peir.path.uab.edu]

  • Choledocholithiasis

    His abdomen was soft and lax, mildly distended with hepatomegaly about 4 cm below the costal margin, round edge, firm, not tender with a span of 8.5 cm, with no other significant[saudisurgj.org] Liver function tests (LFT) can be used to predict CBD stones[ 4 , 5 ].[ncbi.nlm.nih.gov] Initial laboratory work showed elevated liver enzymes such as alkaline phosphatase (ALP): 871, gamma-glutamyl transferase: 435, aspartate aminotransferase: 146, alanine aminotransferase[saudisurgj.org]

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