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64 Possible Causes for Direct Bilirubin Increased, Vitamin K Deficiency

  • Biliary Atresia

    K deficiency bleeding (VKDB) due to cholestasis-induced fat malabsorption.[ncbi.nlm.nih.gov] We evaluated the clinical impact and cost of reflex testing in infants with increased direct bilirubin ( 1.5 mg/dL; 25 μmol/L).[ncbi.nlm.nih.gov] Because of an increasing direct bilirubin level and the absence of bile excretion, a laparotomy was performed at the age of 29 days.[ncbi.nlm.nih.gov]

  • Cholestasis

    Vitamin K Although vitamin K does not treat obstetric cholestasis, it may be required because OC can cause vitamin K deficiency (low vitamin K levels).[medicinesinpregnancy.org] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] AST and ALT may be increased 2 - 20 fold. Total and direct bilirubin may also be significantly elevated.[clinicaladvisor.com]

  • Primary Biliary Cirrhosis

    Later symptoms include jaundice from the accumulation of bile and specific nutritional deficiencies-bruising from vitamin K deficiency, bone pain from vitamin D deficiency[medical-dictionary.thefreedictionary.com] Vitamins A and D as well as deficiencies in vitamin K should be reduced with vitamin supplements. Cholestyramine usually is effective in reducing the itching (pruritus).[articles.chicagotribune.com] deficiencies – including vitamins A, D, E and K a slightly increased risk of developing liver cancer Page last reviewed: 06/11/2017 Next review due: 06/11/2020[nhs.uk]

  • Neonatal Hepatitis

    Vitamin K deficiency is associated with easy bruising and a tendency to bleed, whereas the lack of vitamin E results in poor coordination.[en.wikipedia.org] However, bilirubin again increased to 13.2 mg/dl at 5 months of age in spite of HSV IgG.[mjdrdypu.org] K deficiency • Elevated serum total and conjugated bilirubin • Variably elevated transaminases Microscopic • Lobular disarray with giant cell transformation • Canalicular[basicmedicalkey.com]

  • Liver Failure

    Although these are sensitive tests they may indicate other causes, such as vitamin K deficiency or disseminated intravascular coagulation.[patient.info] These findings translated to tests of upscaled adsorbents in a dynamic model for liver failure: upscaled Hepalbin adsorbent removes bile acids, direct bilirubin and indirect[ncbi.nlm.nih.gov] – measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated (combined with[labtestsonline.org]

  • Choledocholithiasis

    Vitamin K administration. Vitamin K is given to manage the itching, jaundice, and bleeding tendencies due to vitamin K deficiency. NGT insertion.[nurseslabs.com] Still, the most statistically significant and useful predictor found in our study was a ratio of direct bilirubin to total bilirubin greater than 30%.[scielo.org.co] The presence of this predictor increased the probability of choledocholithiasis by 9.25 times (95% CI 1.20 to 65.69) and increased the probability of common bile duct dilation[scielo.org.co]

  • Choledochal Cyst

    We report a case of a two-month-old infant with choledochal cyst presenting as late vitamin K deficiency bleeding (VKDB).[ncbi.nlm.nih.gov] Choledochal cysts are a cause of neonatal cholestasis but rarely produce vitamin K deficiency bleeding.[ncbi.nlm.nih.gov]

  • Congenital Cytomegalovirus Infection

    The authors present a case of a 36-day-old infant with intracranial and intramuscular hemorrhage due to vitamin K deficiency bleeding, who received intramuscular vitamin K[ncbi.nlm.nih.gov] In this case, laboratory tests showed anemia, liver dysfunction with cholestasis, and coagulopathy, consistent with vitamin K deficiency abnormality.[ncbi.nlm.nih.gov]

  • Alcoholic Hepatitis

    K 5mg PO daily for 3 days (will treat concomitant nutritional deficiency of vitamin K) B.[clinicaladvisor.com] Gastrointestinal or Nutrition Issues In the setting of coagulopathy, treat with vitamin K 5mg PO daily for 3 days due to frequent vitamin K deficiency due to malnutrition,[clinicaladvisor.com] Hematologic or Coagulation Issues In the setting of coagulopathy, treat with vitamin K 5mg PO daily for 3 days due to frequent vitamin K deficiency due to malnutrition, although[clinicaladvisor.com]

  • Intrahepatic Cholestasis

    Maternal Hemorrhaging Cholestasis patients have a reduced ability to absorb fat-soluble vitamins (A,D and K). This may lead to Vitamin K deficiency.[liverfoundation.org] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] K deficiency) Fatigue Increased nausea Decrease in appetite Jaundice Upper right quadrant pain It is important to note that not all ICP sufferers have all of the above symptoms[en.wikipedia.org]

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