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47 Possible Causes for Direct Bilirubin Increased, Vitamin K Deficiency

  • Primary Biliary Cirrhosis

    Later symptoms include jaundice from the accumulation of bile and specific nutritional deficiencies-bruising from vitamin K deficiency, bone pain from vitamin D deficiency[medical-dictionary.thefreedictionary.com] Vitamins A and D as well as deficiencies in vitamin K should be reduced with vitamin supplements. Cholestyramine usually is effective in reducing the itching (pruritus).[articles.chicagotribune.com] Finally, fat-soluble vitamin deficiencies are noted with more advanced disease.[ncbi.nlm.nih.gov]

  • Cholestasis

    Vitamin K Although vitamin K does not treat obstetric cholestasis, it may be required because OC can cause vitamin K deficiency (low vitamin K levels).[medicinesinpregnancy.org] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] Malabsorption, especially Vitamin K deficiency Osteomalacia Biliary cirrhosis[rcpa.edu.au]

  • Intrahepatic Cholestasis

    Maternal Hemorrhaging Cholestasis patients have a reduced ability to absorb fat-soluble vitamins (A,D and K). This may lead to Vitamin K deficiency.[liverfoundation.org] Up to 60% of patients will have elevated transaminases and 20% of patients will have increased direct bilirubin levels.[smfm.org] Vitamin K deficiencies are associated with increased risk for hemorrhaging in the mother and child.[pregnancy-info.net]

  • Recurrent Jaundice of Pregnancy

    Maternal Hemorrhaging Cholestasis patients have a reduced ability to absorb fat-soluble vitamins (A,D and K). This may lead to Vitamin K deficiency.[liverfoundation.org] Both ICP and cholestyramine can lead to vitamin K deficiency and coagulopathy in both mother and fetus. 72 Therefore, parenteral vitamin K administration should accompany[glowm.com] Sub clinical steatorrhea may be seen along with fat malabsorption, which may lead to vitamin K deficiency resulting in a prolonged prothrombin time in postpartum hemorrhage[flipper.diff.org]

  • Neonatal Hepatitis

    K deficiency • Elevated serum total and conjugated bilirubin • Variably elevated transaminases Microscopic • Lobular disarray with giant cell transformation • Canalicular[basicmedicalkey.com] However, bilirubin again increased to 13.2 mg/dl at 5 months of age in spite of HSV IgG.[mjdrdypu.org] Vitamin Deficiency- Since infants with Chronic Neonatal Hepatitis are not able to absorb vitamins A, D and K because of absence of bile in intestine.[epainassist.com]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    Fat and lipid-soluble vitamins malabsorption lead to steatorrhea and vitamin deficiencies, particularly regarding vitamins K, A and D.[symptoma.com] K deficiency).[rarediseases.org] deficiency and malabsorption and vitamin K deficiency.[link.springer.com]

  • Choledochal Cyst

    We report a case of a two-month-old infant with choledochal cyst presenting as late vitamin K deficiency bleeding (VKDB).[ncbi.nlm.nih.gov] Choledochal cysts are a cause of neonatal cholestasis but rarely produce vitamin K deficiency bleeding.[ncbi.nlm.nih.gov]

  • Biliary Atresia

    K deficiency bleeding (VKDB) due to cholestasis-induced fat malabsorption.[ncbi.nlm.nih.gov] We evaluated the clinical impact and cost of reflex testing in infants with increased direct bilirubin ( 1.5 mg/dL; 25 μmol/L).[ncbi.nlm.nih.gov] Because of an increasing direct bilirubin level and the absence of bile excretion, a laparotomy was performed at the age of 29 days.[ncbi.nlm.nih.gov]

  • Extrahepatic Cholestasis

    Vitamin K. Cholestasis impaired the capability of the body to absorb the fat-soluble vitamins which will lead to Vitamin K deficiency.[webmedicinecenter.com] An increase in urinary bilirubin is nearly always indicative of a corresponding increase in the serum direct fraction attributable to intrahepatic or extrahepatic cholestasis[medical-dictionary.thefreedictionary.com] Vitamin D deficiency results in osteomalacia and rickets . Vitamin K deficiency causes coagulopathy and possibly reduced brain development.[emedicine.medscape.com]

  • Liver Failure

    Although these are sensitive tests they may indicate other causes, such as vitamin K deficiency or disseminated intravascular coagulation.[patient.info] These findings translated to tests of upscaled adsorbents in a dynamic model for liver failure: upscaled Hepalbin adsorbent removes bile acids, direct bilirubin and indirect[ncbi.nlm.nih.gov] – measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated (combined with[labtestsonline.org]

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