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15 Possible Causes for Discoloration of the Lower Extremity, Dysesthesia, Gangrene

  • Raynaud's Disease

    Dysesthesiae and regional diaphoresis may coincide with the ischemic phase, while throbbing pain often accompanies recovery.[] […] of the toes Gangrene of the fingertips Extreme constriction of blood vessels (peripheral) Tissue hypoxia Skin, muscle, and tissue atrophy Ulceration Ischemic gangrene Raynaud[] An examination revealed venous changes, chronic ulceration, and digit discoloration in upper and lower extremities.[]

  • Phlegmasia Cerulea Dolens

    Because of the patient’s acute onset of objective neurologic signs and concern about her unilateral dysesthesia and weakness, she received an expedited stroke workup that[] OBJECTIVE: Phlegmasia cerulea dolens (PCD) and venous gangrene are limb and life-threatening conditions of iliofemoral acute deep vein thrombosis (DVT).[] The patient returned to the Emergency Department a week later for worsening pain and bluish discoloration of her bilateral lower extremities.[]

  • Henoch-Schönlein Purpura

    […] toxic epidermal necrolysis, epidermolysis bullosa, bullous mastocytosis, pemphigus, bullous pemphigoid, dermatitis herpetiformis, linear IgA dermatosis, bullous impetigo, gangrenous[] […] marked by fever, shock, anemia, and sudden, rapidly spreading symmetrical skin hemorrhages of the lower limbs, often associated with extensive intravascular thromboses and gangrene[]

  • Calcinosis Cutis

    […] and related disorders Keratodermas Kro Dariers disease and HaileyHailey disease Daniel Hohl Theodora Mauro and leanPhilippe Gorog Mosaicism and linear lesions Pruritus and dysesthesia[] In very rare cases, Calcinosis Cutis can cause gangrene due to blockage of blood flow.[] They tend to be distributed bilaterally and symmetrically, and they are most commonly located on the lower extremities, which may relate to poor circulation, as well as the[]

  • Erythromelalgia

    Burning mouth syndrome Diabetic Amyotrophy Reflex Sympathetic Dystrophy (Complex regional pain syndrome) Infections: Herpes zoster Neoplastic infiltration: Burning pain with dysesthesia[] It is possible to get ulceration, necrosis and gangrene as complications of erythromelalgia.[] […] of the lower extremities ( Figure 3 ).[]

  • Livedo Reticularis

    […] and related disorders Keratodermas Kro Dariers disease and HaileyHailey disease Daniel Hohl Theodora Mauro and leanPhilippe Gorog Mosaicism and linear lesions Pruritus and dysesthesia[] Involvement of the blood vessels of the skin can give rise to livedo reticularis, acrocyanosis, ulcers, and gangrene.[] The discoloration typically affects the lower extremities. Many people describe the discoloration as having a net-like or lace appearance.[]

  • Lower Extremity Arterial Aneurysm

    Differential diagnosis Collateral function of a vesselExercise-induced hyperemia- Peripheral inflammation Dysesthesia: While the highest ankle pressure is used in most studies[] Severe cases can progress to gangrene of the distal extremity which can spread proximally.[] Lower Extremity Venous Exam (DVT): An Ultrasound exam performed on the veins in the legs to determine the presence or absence of blood clots, known as deep vein thrombosis[]

  • Diabetic Mononeuropathy

    Numbness and tingling of extremities, Dysesthesia (abnormal sensation to a body part), Diarrhea, Erectile dysfunction, Urinary incontinence (loss of bladder control), Facial[] E11.52 Type 2 diabetes mellitus with diabetic peripheral angiopathy with gangrene E11.59 Type 2 diabetes mellitus with other circulatory complications E11.6 Type 2 diabetes[] Venous insufficiency should be noted if present; it manifests as pitting edema to the lower extremities, and sometimes brawny, brown discoloration to the lower legs up to[]

  • Idiopathic Scrotal Edema

    Atrophy of tunica vaginalis Atrophy of vas deferens Burning scrotum Chylocele Chylocele of tunica vaginalis Cyst of seminal vesicle Cyst of testes Delayed male climacteric Dysesthesia[] Okizuka H, Sugimura K, Yoshizako T (1992) Fournier’s gangrene: diagnosis based on MR findings.[] extremities, with brownish discoloration, discomfort but not marked pain, and sometimes skin ulcers Often associated with varicose veins Clinical evaluation Extrinsic venous[]

  • Small-Fiber Neuropathy

    Dysesthesia, allodynia, pain, burning, and coldness sensations frequently present in a length-dependent pattern.[] […] flow can be so extreme that it can result in serious tissue damage that can lead to serious consequences including the loss of limbs via amputation due to tissue death and gangrene[] Symptoms are potentially numerous and can include allodynia, burning, lower thermal sensation, hyperesthesia, paresthesia, numbness in the lower extremities with potential[]

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