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38 Possible Causes for Discoloration of the Lower Extremity, Elevated Sedimentation Rate

  • Deep Vein Thrombosis

    The patient's left lower extremity was discolored, tender, and swollen, although it had not progressed to venous gangrene or dermal necrosis.[ncbi.nlm.nih.gov] Patients with venous thrombosis may have variable discoloration of the lower extremity.[emedicine.medscape.com] […] of the lower extremity Blanched appearance of the leg because of edema (relatively rare) Potential complications of DVT include the following: As many as 40% of patients[emedicine.medscape.com]

  • Henoch-Schönlein Purpura

    Factors not significantly associated with renal involvement were: blood pressure; orchitis; elevated C-reactive protein; elevated erythrocyte sedimentation rate (ESR); and[ncbi.nlm.nih.gov] Laboratory values on admission revealed leukocytosis (17,500/μL [reference range, 4500–11,000/μL]), elevated erythrocyte sedimentation rate (42 mm/h [reference range, 0–20[mdedge.com] The complete blood count may reveal a normal or elevated white blood cell count and possible eosinophilia. Sedimentation rate and platelet count may be elevated.[aafp.org]

  • Familial Mediterranean Fever

    Many individuals with FMF have an elevated sedimentation rate, which is an indication of inflammation.[rarediseases.org] Upon further questioning, the patient admitted to gradual development of lower extremity edema over the past 2 to 3 months.[bmcnephrol.biomedcentral.com] The C-reactive protein and erythrocyte sedimentation rate were elevated.[ncbi.nlm.nih.gov]

  • Cryoglobulinemia

    In addition to elevated serum cryocrit and evidence of liver pathology, type II cryoglobulinemia usually shows elevated erythrocyte sedimentation rate, hypergammaglobulinemia[woundsresearch.com] She presented with generalized purplish net-like discoloration (livedo reticularis), which was more prominent in the lower extremities.[dbpia.co.kr] […] of white blood cells or platelets (due to cryoprecipitation on an automated counter) Complements: low C4 and CH50 levels, variable C3 levels Elevated erythrocyte sedimentation[clinicaladvisor.com]

  • Varicella

    PCD is the term used to describe lower-extremity DVT that causes limb ischemia, and is characterized by severe swelling and blue discoloration of the extremity.[ebmedicine.net] Postoperatively he developed painful diffuse swelling of his left lower extremity with bluish discoloration ( Figure 58-1 ).[accesssurgery.mhmedical.com] Two days before admission, swelling of the left lower extremity developed, and the diagnosis of partial left femoral vein thrombosis was confirmed by venous duplex ultrasonography[ahajournals.org]

  • Necrotizing Fasciitis

    extremities Perineum and genitourinary region (Fournier's gangrene) Upper extremities Abdomen and trunk What other disease/condition shares some of these symptoms?[clinicaladvisor.com] Hypotension Altered mental status Systemic inflammatory response syndrome Fulminant shock and multiorgan failure Body sites most often affected by necrotizing fasciitis: Lower[clinicaladvisor.com] […] tenderness over the affected area, which is often out of proportion to the overt clinical appearance Systemic toxicity Other Local findings in necrotizing fasciitis: Skin discoloration[clinicaladvisor.com]

  • Rosai-Dorfman Disease

    rate.[ncbi.nlm.nih.gov] On exam, she had weakness of the right lower extremity with pain on knee extension and tenderness to palpation of the surgical incision region in the lateral distal thigh.[pagepress.org] Additional findings may include fever, malaise, epistaxis, night sweats, weight loss, leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia.[orpha.net]

  • Periodontitis

    Other investigations may include complete blood count, erythrocyte sedimentation rate (ESR), venereal disease research laboratory (VDRL) or rapid plasma reagin test, Mantoux[statpearls.com] PCD is the term used to describe lower-extremity DVT that causes limb ischemia, and is characterized by severe swelling and blue discoloration of the extremity.[ebmedicine.net] Postoperatively he developed painful diffuse swelling of his left lower extremity with bluish discoloration (Figure 58-1).[accesssurgery.mhmedical.com]

  • Venous Stasis Ulcer

    The erythrocyte sedimentation rate is frequently elevated in infected ulcers, and values higher than 70 mm/hr should heighten suspicion for osteomyelitis.[clevelandclinicmeded.com] Location Venous stasis ulcer is basically located and found at the distal extremity, lower leg.[howshealth.com] The extravisation of plasma and blood cells accounts for chronic lower extremity edema (CLEE) and accompanying hemosidrin deposits, which often discolor the feet, ankles and[nursing.advanceweb.com]

  • Raynaud's Disease

    Typically, patients with Raynaud's phenomenon that is a manifestation of a rheumatic disease have elevated blood sedimentation rates and antinuclear antibodies.[medicinenet.com] An examination revealed venous changes, chronic ulceration, and digit discoloration in upper and lower extremities.[ncbi.nlm.nih.gov] Blood tests such as sedimentation rate (ESR) and antinuclear antibodies (ANA) can assist in establishing a diagnosis of connective tissue disease.[evergreenhealth.com]

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