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2,750 Possible Causes for Discoloration of the Lower Extremity, Fingertip Ulceration, Gangrene

  • Raynaud's Disease

    […] of the toes Gangrene of the fingertips Extreme constriction of blood vessels (peripheral) Tissue hypoxia Skin, muscle, and tissue atrophy Ulceration Ischemic gangrene Raynaud[] Trophic changes of sclerodactyly and, rarely, fingertip ulcerations or gangrene,[] An examination revealed venous changes, chronic ulceration, and digit discoloration in upper and lower extremities.[]

  • Thromboangiitis Obliterans

    Human disease Buerger's disease Presenile gangrene Presenile gangrene (disorder) Thromboangiitis obliterans (disorder) Thromboangiitis obliterans NOS (disorder) Thromboangiitis[] Critical blood flow was discovered in the middle, ring, and little finger, with ischemic ulcerations apparent in the fingertips of these 3 fingers.[] extremities.[]

  • Calcinosis Cutis

    In very rare cases, Calcinosis Cutis can cause gangrene due to blockage of blood flow.[] In the setting of dermatomyositis, calcinosis cutis is associated with longer disease duration, fingertip ulcers, and NXP-2 autoantibodies.[] They tend to be distributed bilaterally and symmetrically, and they are most commonly located on the lower extremities, which may relate to poor circulation, as well as the[]

  • Raynaud Phenomenon

    In addition to pain and functional impairment, Raynaud phenomenon can produce tissue ischaemia resulting in digital ulceration and gangrene.[] Care of the nails must be done carefully to avoid injuring sensitive toes and fingertips. Ulcers on the tips of the digits should be monitored closely by the doctor.[] Although cold agglutinins or cryoglobulins may lead to severe acral gangrene the finding of relevant titers is rare.[]

    Missing: Discoloration of the Lower Extremity
  • Vasculitis

    Juvenile gangrenous vasculitis of the scrotum is a rare entity, of which to our knowledge we describe the first documented case in the UK.[] Chilblain lupus is a skin disease characterized by blue-reddish coloring, swelling or ulcers on acral regions of body such as fingertips, heels, nose and auricles.[] It can produce deep dermal ulcers, localized skin infarction, ischemia or necrosis of the fingertips, scleritis, and inflammation of multiple nerves (mononeuritis multiplex[]

    Missing: Discoloration of the Lower Extremity
  • Thrombosis

    Examinations after death have shown that thrombosis exists for some distance around the gangrenous mass.[] Patients with venous thrombosis may have variable discoloration of the lower extremity.[] […] aortic atheroscloeric plaques – small pieces of atheromatous material break off and cause small artery occlusions à strokes, acute renal failure, “blue toe syndrome,” ulcers/gangrene[]

    Missing: Fingertip Ulceration
  • Limited Cutaneous Systemic Scleroderma

    She required amputation of the 5th phalanx of foot because of gangrene due to Raynaud's syndrome. Anesthesia was induced with propofol, and a size 3 PLMA was inserted.[] Skin ulcerations may arise from Raynaud's related peripheral vascular insufficiency (fingertips), from scleroderma related skin tightness (extensor surfaces of the proximal[] Raynaud phenomenon in the fingers and toes can cause ulcers and gangrene due to the disruption of the blood flow towards them.[]

    Missing: Discoloration of the Lower Extremity
  • Phlegmasia Cerulea Dolens

    OBJECTIVE: Phlegmasia cerulea dolens (PCD) and venous gangrene are limb and life-threatening conditions of iliofemoral acute deep vein thrombosis (DVT).[] The patient returned to the Emergency Department a week later for worsening pain and bluish discoloration of her bilateral lower extremities.[] After five days of therapeutic heparin, the patient's clinical response was inadequate due to progressive pain and discoloration of bilateral lower extremities; therefore,[]

    Missing: Fingertip Ulceration
  • Sclerodactyly

    This tissue damage can cause gangrene, or decay of the tissue, which will often require the affected areas to be amputated.[] The fingertips may be ulcerated.[] Gangrenous necrosis can be considered a type of coagulative necrosis that resembles mummified tissue and it is characteristic of ischemia of lower limb and the gastrointestinal[]

    Missing: Discoloration of the Lower Extremity
  • Diffuse Scleroderma

    More than 90% of individuals with SSc have vascular complications including Raynaud phenomenon, digital ulcers or gangrene and pulmonary hypertension, with microvascular abnormalities[] ulceration, oesophageal symptoms Organs affected - risk of renal (acute or chronic failure), cardiac (conduction defect,arrhythmia, pericarditis), pulmonary fibrosis, pulmonary[] Amputation may be necessary in patients, whose finger ulcers have developed gangrene.[]

    Missing: Discoloration of the Lower Extremity

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