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2,750 Possible Causes for Discoloration of the Lower Extremity, Fingertip Ulceration, Gangrene

  • Raynaud's Disease

    […] of the toes Gangrene of the fingertips Extreme constriction of blood vessels (peripheral) Tissue hypoxia Skin, muscle, and tissue atrophy Ulceration Ischemic gangrene Raynaud[disability-benefits-help.org] Trophic changes of sclerodactyly and, rarely, fingertip ulcerations or gangrene,[jamanetwork.com] An examination revealed venous changes, chronic ulceration, and digit discoloration in upper and lower extremities.[ncbi.nlm.nih.gov]

  • Thromboangiitis Obliterans

    Human disease Buerger's disease Presenile gangrene Presenile gangrene (disorder) Thromboangiitis obliterans (disorder) Thromboangiitis obliterans NOS (disorder) Thromboangiitis[wikidata.org] Critical blood flow was discovered in the middle, ring, and little finger, with ischemic ulcerations apparent in the fingertips of these 3 fingers.[ncbi.nlm.nih.gov] extremities.[vasculardiseasemanagement.com]

  • Calcinosis Cutis

    In very rare cases, Calcinosis Cutis can cause gangrene due to blockage of blood flow.[epainassist.com] In the setting of dermatomyositis, calcinosis cutis is associated with longer disease duration, fingertip ulcers, and NXP-2 autoantibodies.[emedicine.com] They tend to be distributed bilaterally and symmetrically, and they are most commonly located on the lower extremities, which may relate to poor circulation, as well as the[cjasn.asnjournals.org]

  • Raynaud Phenomenon

    In addition to pain and functional impairment, Raynaud phenomenon can produce tissue ischaemia resulting in digital ulceration and gangrene.[ncbi.nlm.nih.gov] Care of the nails must be done carefully to avoid injuring sensitive toes and fingertips. Ulcers on the tips of the digits should be monitored closely by the doctor.[rxlist.com] Although cold agglutinins or cryoglobulins may lead to severe acral gangrene the finding of relevant titers is rare.[ncbi.nlm.nih.gov]

    Missing: Discoloration of the Lower Extremity
  • Vasculitis

    Juvenile gangrenous vasculitis of the scrotum is a rare entity, of which to our knowledge we describe the first documented case in the UK.[ncbi.nlm.nih.gov] Chilblain lupus is a skin disease characterized by blue-reddish coloring, swelling or ulcers on acral regions of body such as fingertips, heels, nose and auricles.[ncbi.nlm.nih.gov] It can produce deep dermal ulcers, localized skin infarction, ischemia or necrosis of the fingertips, scleritis, and inflammation of multiple nerves (mononeuritis multiplex[medical-dictionary.thefreedictionary.com]

    Missing: Discoloration of the Lower Extremity
  • Thrombosis

    Examinations after death have shown that thrombosis exists for some distance around the gangrenous mass.[thesaurus.com] Patients with venous thrombosis may have variable discoloration of the lower extremity.[emedicine.medscape.com] […] aortic atheroscloeric plaques – small pieces of atheromatous material break off and cause small artery occlusions à strokes, acute renal failure, “blue toe syndrome,” ulcers/gangrene[errolozdalga.com]

    Missing: Fingertip Ulceration
  • Limited Cutaneous Systemic Scleroderma

    She required amputation of the 5th phalanx of foot because of gangrene due to Raynaud's syndrome. Anesthesia was induced with propofol, and a size 3 PLMA was inserted.[ncbi.nlm.nih.gov] Skin ulcerations may arise from Raynaud's related peripheral vascular insufficiency (fingertips), from scleroderma related skin tightness (extensor surfaces of the proximal[eatonhand.com] Raynaud phenomenon in the fingers and toes can cause ulcers and gangrene due to the disruption of the blood flow towards them.[symptoma.com]

    Missing: Discoloration of the Lower Extremity
  • Phlegmasia Cerulea Dolens

    OBJECTIVE: Phlegmasia cerulea dolens (PCD) and venous gangrene are limb and life-threatening conditions of iliofemoral acute deep vein thrombosis (DVT).[ncbi.nlm.nih.gov] The patient returned to the Emergency Department a week later for worsening pain and bluish discoloration of her bilateral lower extremities.[ncbi.nlm.nih.gov] After five days of therapeutic heparin, the patient's clinical response was inadequate due to progressive pain and discoloration of bilateral lower extremities; therefore,[ijcasereportsandimages.com]

    Missing: Fingertip Ulceration
  • Sclerodactyly

    This tissue damage can cause gangrene, or decay of the tissue, which will often require the affected areas to be amputated.[wisegeek.com] The fingertips may be ulcerated.[medical-dictionary.thefreedictionary.com] Gangrenous necrosis can be considered a type of coagulative necrosis that resembles mummified tissue and it is characteristic of ischemia of lower limb and the gastrointestinal[wikivisually.com]

    Missing: Discoloration of the Lower Extremity
  • Diffuse Scleroderma

    More than 90% of individuals with SSc have vascular complications including Raynaud phenomenon, digital ulcers or gangrene and pulmonary hypertension, with microvascular abnormalities[grantome.com] ulceration, oesophageal symptoms Organs affected - risk of renal (acute or chronic failure), cardiac (conduction defect,arrhythmia, pericarditis), pulmonary fibrosis, pulmonary[barts.wikia.com] Amputation may be necessary in patients, whose finger ulcers have developed gangrene.[dovemed.com]

    Missing: Discoloration of the Lower Extremity

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