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96 Possible Causes for Disseminated Intravascular Coagulation, Massive Splenomegaly, Pancytopenia

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] Platelet dysfunction, acquired factor V deficiency, thrombocytopenia, disseminated intravascular coagulation, oesophageal varices and peptic ulcer disease may occur.[patient.info] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] Disseminated intravascular coagulation. In K Kaushanksy et al., eds., Williams Hematology, 8th ed., pp. 2101–2120. New York: McGraw-Hill.[healthlinkbc.ca] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Disseminated Histoplasmosis

    His fever persisted, and a laboratory examination indicated severe thrombocytopenia with disseminated intravascular coagulation. He died on day 43 postadmission.[ncbi.nlm.nih.gov] She was complaining from fever, chronic diarrhoea and pancytopenia.[ncbi.nlm.nih.gov] Presenting symptoms included fever, hepatosplenomegaly and pancytopenia. Bone marrow biopsy confirmed HLH.[ncbi.nlm.nih.gov]

  • Non-Hodgkin Lymphoma

    […] antibiotic therapy may result in remission of the disease.[ 97 ] Splenic marginal zone lymphoma Splenic marginal zone lymphoma is an indolent lymphoma that is marked by massive[web.archive.org] Bleeding secondary to thrombocytopenia, disseminated intravascular coagulation or direct vascular invasion by the tumour.[patient.info] Leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow;[icd9data.com]

  • Acute Erythroblastic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] Both forms of acute promyelocytic leukemia are associated with a high incidence of disseminated intravascular coagulation (DIC) and hemorrhage.[med-ed.virginia.edu] The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] The only grade III or IV toxicities demonstrated were culture-negative febrile neutropenia, transient and reversible disseminated intravascular coagulation related to rituximab[ncbi.nlm.nih.gov] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov]

  • Hypersplenism

    CONCLUSION: Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe[ncbi.nlm.nih.gov] intravascular coagulation—thus making this syndrome a true medical emergency.[emedicine.medscape.com] Hypersplenism should be considered in patients with persistent or recurrent pancytopenia and splenomegaly post-transplantation.[ncbi.nlm.nih.gov]

  • Promyelocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] Intravascular Coagulation*/blood Disseminated Intravascular Coagulation*/chemically induced Disseminated Intravascular Coagulation*/genetics Disseminated Intravascular Coagulation[ncbi.nlm.nih.gov] We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[ncbi.nlm.nih.gov]

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