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408 Possible Causes for Distal Limb Muscle Weakness

  • Oculopharyngeal Muscular Dystrophy

    The distribution of muscle weakness in the propositus and in one of his sisters was proximal in the upper, but distal in the lower limbs, confirming the existence of a relationship[ncbi.nlm.nih.gov] limb musculature.[ncbi.nlm.nih.gov] Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease onset Limb strength normal (20%) Progression: To proximal muscles Respiratory Common[neuromuscular.wustl.edu]

  • Mitochondrial DNA Depletion Syndrome Type 1

    Mitochondrial neurogastrointestinal encephalopathy (MNGIE), usually an autosomal-recessive inherited condition, causes gastrointestinal dysmotility, ophthalmoplegia, ptosis, leukoencephalopathy and neuropathy. The chromosome 22 disorder, due to mutations in the nuclear gene TYMP encoding thymidine phosphorylase (TP),[…][ncbi.nlm.nih.gov]

  • Distal Hereditary Motor Neuropathy

    Chapter First Online: 06 October 2017 Abstract Distal hereditary motor neuropathies (HMNs) are characterized by distal limb muscle weakness, occurring first in the legs and[link.springer.com] […] motor neuropathy is a heterogeneous group of inherited neuropathies characterized by distal limb muscle weakness and atrophy.[miami.pure.elsevier.com] 20 May 2017 Distal hereditary motor neuropathy is a heterogeneous group of inherited neuropathies characterised by distal limb muscle weakness and atrophy.[institut-myologie.org]

  • Oculopharyngodistal Myopathy

    Oculopharyngodistal myopathy is an uncommon myopathy characterised clinically by cranial and distal limb muscle weakness.[ncbi.nlm.nih.gov] The patients came from 10 unrelated families and presented with progressive external ocular, laryngopharyngeal, facial, distal limb muscle weakness that had been present since[ncbi.nlm.nih.gov] Pharyngeal and distal limb muscles seem to be primarily involved.[disorders.eyes.arizona.edu]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G

    0008944 Distal lower limb muscle weakness 0009053 Elevated serum creatine kinase Elevated blood creatine phosphokinase Elevated circulating creatine phosphokinase Elevated[rarediseases.info.nih.gov] UniProtKB/Swiss-Prot : 75 Limb-girdle muscular dystrophy 2G: An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy[malacards.org] A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle[medical-dictionary.thefreedictionary.com]

  • Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] limbs in a “stocking and glove” distribution.[aafp.org] In the early stages of peripheral neuropathy, patients typically present with progressive symptoms, including sensory loss, numbness, and pain or burning sensations in distal[aafp.org]

  • Peripheral Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] limbs in a “stocking and glove” distribution.[aafp.org] In the early stages of peripheral neuropathy, patients typically present with progressive symptoms, including sensory loss, numbness, and pain or burning sensations in distal[aafp.org]

  • Polyneuropathy

    Our patient had acute onset of prominent weakness in proximal muscles of lower limbs and clinical symptoms and signs of distal peripheral polyneuropathy.[scielo.br]

  • Distal Myopathy

    Progressive weakness of distal limb extensor muscles and mild weakness of the neck flexor and proximal muscles were noted.[ncbi.nlm.nih.gov] […] of the distal muscles of the upper and lower limbs.[athenadiagnostics.com] Welander distal myopathy (WDM) is a late adult-onset autosomal dominant disorder, characterized by a slow progression and distal limb weakness of the extremity muscles.[ncbi.nlm.nih.gov]

  • Spinal Muscular Atrophy with Respiratory Distress Type 1

    (distal lower limbs mainly involved), muscle atrophy, and peripheral sensory neuropathy.[ncbi.nlm.nih.gov] limb muscle involvement.[ncbi.nlm.nih.gov] muscle weakness and atrophy (in lower limbs especially).[orpha.net]

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