Distal Muscle Weakness: Causes & Reasons

Possible Causes for Distal Muscle Weakness

Some patients also have involvement of the upper limbs and/or distal muscle weakness. The age at onset is highly variable, and the disorder is slowly progressive. [ncbi.nlm.nih.gov]

Distal muscle weakness MedGen UID: 140883 •Concept ID: C0427065 • Finding Reduced strength of the musculature of the distal extremities. [ncbi.nlm.nih.gov]

muscle weakness Skeletal muscle atrophy Limb-girdle muscle weakness Slow progression Variable expressivity ... [familydiagnosis.com]

Amyotrophic Lateral Sclerosis Type 5

muscle weakness and atrophy, foot deformities, distal sensory loss, as well as diminished tendon reflexes. [semanticscholar.org]

Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal muscle weakness and atrophy, foot deformities [ncbi.nlm.nih.gov]

[…] neurology 2016 DOI: 10.1093/brain/awv320 Charcot-Marie-Tooth disease is a group of hereditary peripheral neuropathies that share clinical characteristics of progressive distal [semanticscholar.org]

Distal Spinal Muscular Atrophy Type 5

Get Update Overview HMSNO is an autosomal dominant neurodegenerative disorder characterized by young adult onset of proximal or distal muscle weakness and atrophy, muscle [diseaseinfosearch.org]

muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. [genecards.org]

Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. [ojrd.biomedcentral.com]

Distal Spinal Muscular Atrophy Type 1

Spinal muscular atrophy with respiratory distress type 1 is an autosomal recessive disorder with early respiratory difficulties, distal muscle weakness, and contractures leading [ncbi.nlm.nih.gov]

She manifested the characteristic clinical features, including early-onset respiratory failure due to diaphragmatic paralysis and severe distal muscle weakness. [ncbi.nlm.nih.gov]

[…] due to intercostal muscle atrophy, infants with distal spinal muscular atrophy 1 usually present with distal muscle weakness, foot deformities, and sudden respiratory failure [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

muscle weakness of lower limbs Proximal muscle weakness and early involvements of foot and hand Muscle weakness Upper limb, proximal No Yes Upper limb, distal Yes Yes Lower [ojrd.biomedcentral.com]

Distal muscle weakness Sensory and autonomic nervous system may also be involved Amyotrophic lateral sclerosis The upper motor neuron controlling muscle movement gradually [thehumanthebody.com]

Distal muscle weakness. Sensory and autonomic nervous systems may also be involved. Bulbo-SMA, or Kennedy's syndrome Age of onset : 20-40 years. [patient.info]

Distal Hereditary Motor Neuropathy Type 1

Charcot-Marie-Tooth hereditary neuropathy type 2 (CMT2) is a non-demyelinating (axonal) peripheral neuropathy characterized by distal muscle weakness and atrophy, mild sensory [bcbst.com]

They developed mild symmetrical distal lower limb weakness, muscle wasting, and severe foot… CONTINUE READING [semanticscholar.org]

The clinical features include distal muscle weakness, impaired sensation, and absent or diminished DTRs. [academlib.com]

X-linked Distal Spinal Muscular Atrophy Type 3

[…] a rare distal hereditary motor neuropathy characterized by slowly progressive atrophy and weakness of distal muscles of hands and feet with normal deep tendon reflexes or [orpha.net]

Distal muscle weakness. Sensory and autonomic nervous systems may also be involved. Bulbo-SMA, or Kennedy's syndrome Age of onset : 20-40 years. [patient.info]

The weakness tends to be more severe in the muscles that are close to the center of the body (proximal) compared to muscles away from the body's center (distal). [ghr.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 3

Early involvement of the diaphragm and predominance of distal muscle weakness clearly distinguishes SMARD1 from Type 1 SMA. [smasupport.com]

Distal muscle weakness Sensory and autonomic nervous system may also be involved Amyotrophic lateral sclerosis The upper motor neuron controlling muscle movement gradually [thehumanthebody.com]

[…] a rare distal hereditary motor neuropathy characterized by slowly progressive atrophy and weakness of distal muscles of hands and feet with normal deep tendon reflexes or [orpha.net]

Hereditary Proximal Myopathy with Early Respiratory Failure

muscle weakness Critical illness neuropathy Failure to wean off ventilation Amyloid myopathy Rare Proximal > distal muscle weakness Pseudohypertrophy of muscles Palpable [clevelandclinicmeded.com]

Distal muscle weakness is present in about 80% of individuals. [ncbi.nlm.nih.gov]

GNE-related myopathy (IBM2) typically presents in the late teens to early adulthood with slowly progressive distal muscle weakness involving gait disturbance and foot drop [invitae.com]

Limb-Girdle Muscular Dystrophy Type 1F

Affected individuals also have distal muscle weakness of the hands and lower leg muscles. [uniprot.org]

Affected individuals also have distal muscle weakness of the hands and lower leg muscles. There is variability in presentation and progression. [ncbi.nlm.nih.gov]

In the more severely affected patients, distal muscle weakness occurred in the advanced stages of the disease, when also winging scapulae, scoliosis, and occasional facial [link.springer.com]

Distal Myopathy Type 3

[…] early adulthood distal leg muscle atrophy and weakness FHL1 myofibrillar myopathy ✓ variable (childhood to adulthood) distal and/or proximal muscle weakness FLNC distal myopathy [invitae.com]

We report a sporadic case of DMRV in a 40-year-old Thai man who presented with slowly progressive distal muscle weakness. [karger.com]

Limb-Girdle Muscular Dystrophy Type 2G

A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle [medical-dictionary.thefreedictionary.com]

UniProtKB/Swiss-Prot : 75 Limb-girdle muscular dystrophy 2G: An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy [malacards.org]

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Limb-Girdle Muscular Dystrophy Type 1E

In the more severely affected patients, distal muscle weakness occurred in the advanced stages of the disease, when also winging scapulae, scoliosis, and occasional facial [link.springer.com]

Affected individuals also have distal muscle weakness of the hands and lower leg muscles. [genecards.org]

Limb-Girdle Muscular Dystrophy Type 1G

Distal muscle weakness may occur later. [mendelian.co]

Affected individuals also have distal muscle weakness of the hands and lower leg muscles. [genecards.org]

Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. [binfo.ncku.edu.tw]

Oculo-Pharyngo-Distal Myopathy

muscle weakness and myopathological rimmed vacuole changes. [ncbi.nlm.nih.gov]

Oculopharyngodistal myopathy is an uncommon myopathy characterised clinically by cranial and distal limb muscle weakness. [ncbi.nlm.nih.gov]

weakness, and distal muscle weakness [ 1, 2 ]. [journals.plos.org]

Muscular Dystrophy-Dystroglycanopathy Type C14

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Facial and distal muscles are typically spared, although distal muscle weakness can occur in the later stages of disease. [invitae.com]

Limb-Girdle Muscular Dystrophy Type 2C

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Distal muscle involvement occurred late in the course of the disease. Facial weakness was a rare phenomenon. [scinapse.io]

Distal muscle weakness may occur in severe cases or later in the disease course. [omicsonline.org]

Distal Spinal Muscular Atrophy

We present the case of a female patient, of 37-years-old, with distal muscle weakness and atrophy beginning in childhood and slowly progressive in the first two decades of [ncbi.nlm.nih.gov]

PATIENTS AND METHODS: A 55-year-old woman presented with weakness of both hands at the age of 45. At age 47, she noticed distal muscle weakness and atrophy in her legs. [ncbi.nlm.nih.gov]

AB - Distal hereditary motor neuropathy is a heterogeneous group of inherited neuropathies characterized by distal limb muscle weakness and atrophy. [miami.pure.elsevier.com]

Secondary Myopathy

muscle weakness (clinically resembling limb-girdle muscular dystrophy; see this term); early-onset Paget disease of bone (see this term), manifesting with bone pain, deformity [orpha.net]

[…] predominantly affecting limbs and respiratory muscles tends to cause distal muscle weakness (as do inflammatory, diabetic, porphyria neuropathy), particularly affecting lower [aic.cuhk.edu.hk]

Muscular Dystrophy-Dystroglycanopathy Type C3

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Distal muscle weakness may occur in severe cases or later in the disease course. [omicsonline.org]

Facial and distal muscles are typically spared, although distal muscle weakness can occur in the later stages of disease. [invitae.com]

Limb-Girdle Muscular Dystrophy Type 2Q

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Facial and distal muscles are typically spared, although distal muscle weakness can occur in the later stages of disease. [invitae.com]

Muscular Dystrophy-Dystroglycanopathy Type C9

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

Miyoshi myopathy is characterized by muscle weakness and atrophy in young adults, most marked in the distal parts of the legs. [egl-eurofins.com]

Hereditary Sensory Neuropathy

Clinical presentation combined symptoms of hereditary sensory and autonomic neuropathy type I (HSAN-I) with prominent distal muscle weakness. [ncbi.nlm.nih.gov]

Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. [ncbi.nlm.nih.gov]

Initial symptoms are sensory loss in the feet followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations. [ncbi.nlm.nih.gov]

Hereditary Areflexic Dystasia

[…] amyotrophy ; Distal muscle weakness ; Distal sensory impairment ; Gait ataxia ; Hammertoe ; Hypertrophic nerve changes ; Hyporeflexia ; Juvenile onset ; Kyphoscoliosis ; [mousephenotype.org]

muscle weakness and atrophy. [abcam.com]

muscle weakness and atrophy associated with impaired distal sensation. [mendelian.co]

Distal Hereditary Motor Neuropathy Type 5A

Charcot-Marie-Tooth hereditary neuropathy type 2 (CMT2) is a non-demyelinating (axonal) peripheral neuropathy characterized by distal muscle weakness and atrophy, mild sensory [bcbst.com]

Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic. Autonomic features (usually sweating disturbances) are invariably observed. [ojrd.biomedcentral.com]

The disorder was characterized primarily by diffuse muscle weakness with prominent distal atrophy. [ucdavis.pure.elsevier.com]

Lower Motor Neuron Syndrome with Late-Adult Onset

Based on the pattern of weakness, we identified three groups: 13 patients with generalized weakness (group 1); eight patients with symmetrical, distal muscle weakness (group [ncbi.nlm.nih.gov]

Distal muscle weakness Sensory and autonomic nervous system may also be involved Amyotrophic lateral sclerosis The upper motor neuron controlling muscle movement gradually [thehumanthebody.com]

Based on the finding of pathological features in family B that also occur in ALS, together with the distal asymmetrical muscle weakness and bulbar signs and a high age at [link.springer.com]

Charcot-Marie-Tooth Disease Type 2S

muscle weakness and atrophy affecting the lower and upper limbs. [ncbi.nlm.nih.gov]

muscle weakness and atrophy. [medical-dictionary.thefreedictionary.com]

Symptoms typically include progressive distal muscle weakness and atrophy, often associated with mild to moderate sensory loss, depressed tendon reflexes, and high-arched [flybase.org]

Limb-Girdle Muscular Dystrophy Type 1H

Distal muscle weakness may occur later. [mendelian.co]

[…] disorder characterized by onset in young adulthood of distal muscle weakness affecting the upper and lower limbs but sparing the intrinsic hand muscles. [mendelian.co]

[…] group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal [abcam.com]

Limb-Girdle Muscular Dystrophy Type 2J

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

Facial and distal muscles are typically spared, although distal muscle weakness can occur in the later stages of disease. [invitae.com]

eventually involving the distal muscles. [orpha.net]

Alpha-B Crystallinopathy

Muscle weakness most often begins in the hands and feet (distal muscles), but some people first experience weakness in the muscles near the center of the body (proximal muscles [ncbi.nlm.nih.gov]

[…] proximal and distal muscles and associated with respiratory insufficiency, cardiomyopathy, and cataracts. [ncbi.nlm.nih.gov]

distal < proximal muscle weakness LDB3 LDB3 ( ZASP ) AD Yes Adult or late onset, occasional childhood onset; distal > proximal muscle weakness; sometimes neuropathy BAG3 [musculoskeletalkey.com]