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424 Possible Causes for Distal Muscle Weakness and Atrophy

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G

    A rare autosomal recessive degenerative myopathy (OMIM:601954) characterised by proximal and distal muscle weakness and atrophy in the limbs, dystrophic changes on muscle[medical-dictionary.thefreedictionary.com] UniProtKB/Swiss-Prot : 75 Limb-girdle muscular dystrophy 2G: An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy[malacards.org] Limb-girdle muscular dystrophy 2G (LGMD2G) [MIM:601954]: An autosomal recessive degenerative myopathy characterized by proximal and distal muscle weakness and atrophy in the[genecards.org]

  • Distal Hereditary Motor Neuropathy

    We present the case of a female patient, of 37-years-old, with distal muscle weakness and atrophy beginning in childhood and slowly progressive in the first two decades of[ncbi.nlm.nih.gov] PATIENTS AND METHODS: A 55-year-old woman presented with weakness of both hands at the age of 45. At age 47, she noticed distal muscle weakness and atrophy in her legs.[ncbi.nlm.nih.gov] […] motor neuropathy is a heterogeneous group of inherited neuropathies characterized by distal limb muscle weakness and atrophy.[miami.pure.elsevier.com]

  • Spinal Muscular Atrophy with Respiratory Distress Type 1

    […] palsy, symmetrical distal muscular weakness, muscle atrophy, peripheral sensory neuropathy and autonomic nerve dysfunction.[ncbi.nlm.nih.gov] muscle weakness and atrophy (in lower limbs especially).[orpha.net] […] due to intercostal muscle atrophy, infants with distal spinal muscular atrophy 1 usually present with distal muscle weakness, foot deformities, and sudden respiratory failure[ncbi.nlm.nih.gov]

  • Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome

    muscle weakness and atrophy.[ab-y-ss.com] Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness[antibodyplus.com] Limb-girdle muscular dystrophy 1B (LGMD1B) : A recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness[sinobiological.com]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Get Update Overview HMSNO is an autosomal dominant neurodegenerative disorder characterized by young adult onset of proximal or distal muscle weakness and atrophy, muscle[diseaseinfosearch.org] distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves.[genecards.org] Common features are muscle weakness (distal or proximal) with atrophy and hyporeflexia, but no sensory involvement. They can be acquired or hereditary.[em-consulte.com]

  • Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] It includes numerous syndromes characterized by varying degrees of sensory disturbances, pain, muscle weakness and atrophy, diminished deep tendon reflexes, and vasomotor[msdmanuals.com] Types I and II are characterized by weakness and atrophy, primarily in peroneal and distal leg muscles. Patients often have a family history of neuropathy.[merckmanuals.com]

  • Peripheral Neuropathy

    Over time, the numbness may extend proximally, and mild distal muscle weakness and atrophy may occur.[aafp.org] It includes numerous syndromes characterized by varying degrees of sensory disturbances, pain, muscle weakness and atrophy, diminished deep tendon reflexes, and vasomotor[merckmanuals.com] The presence of neuropathic symptoms, decreased ankle reflexes, and decreased distal sensations, regardless of distal muscle weakness and atrophy, makes the diagnosis of peripheral[aafp.org]

  • Polyneuropathy

    On motor examination, mild distal weakness was observed in 38 patients (41%) and distal muscle atrophy was observed in 14 (15%).[jamanetwork.com] […] polyneuropathy feeling extremely sensitive to touch, known as allodynia numbness feeling weak in your legs or arms (sometimes due to weak or atrophied muscles) inability[healthline.com] Axonal degenerative polyneuropathies tend to produce weakness along with muscle atrophy, but atrophy is much less conspicuous in segmental demyelinating polyneuropathies because[clevelandclinicmeded.com]

  • Tibial Muscular Dystrophy

    […] myopathy muscle weakness & atrophy generally confined to anterior compartment of lower leg , i.e. tibialis anterior muscle symptoms usually occur at age 35-45 years or much[anvita.info] Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle.[uniprot.org] Distal muscle weakness and atrophy is frequently the presenting symptom and sign in myopathies otherwise characterized by the histopathological findings of myofibrillar myopathy[medlink.com]

  • Sepsis

    In addition, muscle weakness—a muscular disability rating score (MDRS) of 1 was no deficit; 2, minimal deficit or atrophy; 3, mild to moderate distal deficit; 4, mild to moderate[jama.ama-assn.org]

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