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14 Possible Causes for Distal Muscle Weakness - Occurs Initially

  • Spinal and Bulbar Muscular Atrophy

    Without a sufficient number of motor neurons, initiation and maintenance of muscle contractions can no longer occur, leading to progressive muscle wasting.[orpha.net] Recently, a BSMA phenotype with distal predominance of limb weakness and wasting has been reported, caused by mutations in a subunit of the dynactin 1 DCTN1 gene.[orpha.net]

  • Distal Hereditary Motor Neuropathy Type 1

    Distal weakness develops initially in intrinsic muscles of the feet and hands with development of wasting of musculature occurring slowly over time (Figure 18.12).[academlib.com]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    […] spinal muscular atrophy type V, for whom disease onset typically occurs during adolescence or young adulthood, initially manifesting as weakness and atrophy of the hand muscles[journals.plos.org] Published: August 5, 2015 Abstract Background Mutations in the GARS gene have been identified in a small number of patients with Charcot-Marie-Tooth disease (CMT) type 2D or distal[journals.plos.org]

  • Hereditary Motor and Sensory Neuropathy

    Distal weakness develops initially in intrinsic muscles of the feet and hands with development of wasting of musculature occurring slowly over time (Figure 18.12).[academlib.com] […] painful proximal muscle weakness; distal sensory loss may occur Treatment : control of blood glucose and foot care Alcoholic polyneuropathy Definition : progressive peripheral[amboss.com] […] anhidrosis ;, edema, ulcers Autonomic features: erectile dysfunction, gastric atony ;, postprandial diarrhea, tachycardia at rest, impaired pupillary tone Diabetic amyotrophy: initially[amboss.com]

  • Foster-Kennedy Syndrome

    Without a sufficient number of motor neurons, initiation and maintenance of muscle contractions can no longer occur, leading to progressive muscle wasting.[orpha.net] Recently, a BSMA phenotype with distal predominance of limb weakness and wasting has been reported, caused by mutations in a subunit of the dynactin 1 DCTN1 gene.[orpha.net]

  • Mononeuritis

    […] painful proximal muscle weakness; distal sensory loss may occur Treatment : control of blood glucose and foot care Alcoholic polyneuropathy Definition : progressive peripheral[amboss.com] […] anhidrosis ;, edema, ulcers Autonomic features: erectile dysfunction, gastric atony ;, postprandial diarrhea, tachycardia at rest, impaired pupillary tone Diabetic amyotrophy: initially[amboss.com]

  • Arsenic-Induced Polyneuropathy

    […] painful proximal muscle weakness; distal sensory loss may occur Treatment : control of blood glucose and foot care Alcoholic polyneuropathy Definition : progressive peripheral[amboss.com] […] anhidrosis ;, edema, ulcers Autonomic features: erectile dysfunction, gastric atony ;, postprandial diarrhea, tachycardia at rest, impaired pupillary tone Diabetic amyotrophy: initially[amboss.com]

  • Nemaline Myopathy

    […] proximal pattern of weakness and distal involvement usually occurring later ( 9 ).[doi.org] A general aspect of NEM patients is the weakness of respiratory muscle that tends to be greater than that of other muscle groups ( 9 ).[doi.org] For example, in 5-week-old Neb cKO mice (an early age at which nebulin levels have fallen to 9 ) with the typical form of nebulin-based NEM characterized by an initially predominately[doi.org]

  • Mononeuritis Multiplex

    […] painful proximal muscle weakness; distal sensory loss may occur Treatment : control of blood glucose and foot care Alcoholic polyneuropathy Definition : progressive peripheral[amboss.com] […] anhidrosis ;, edema, ulcers Autonomic features: erectile dysfunction, gastric atony ;, postprandial diarrhea, tachycardia at rest, impaired pupillary tone Diabetic amyotrophy: initially[amboss.com]

  • Postpoliomyelitis Syndrome

    Commonly seen findings in PPS include progressive weakness, which always occurs in the muscle groups that were affected during the initial illness.[clinicaladvisor.com] The initial balance between denervation and reinnervation of muscle fibres becomes disrupted and when denervation predominates, progressive muscle weakness occurs.[doi.org] The weakness is usually asymmetric, and it may be proximal or distal. Atrophy is present in 50% of patients.[clinicaladvisor.com]

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