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693 Possible Causes for Disturbance of Growth, Hyperpigmentation

  • Vitamin B12 Deficiency

    Hyperpigmentation as the first presentation of Vitamin B12 deficiency is rare.[] The team looked at changes in soil phosphorus (an essential nutrient for tree growth) and how much disturbance there had been in the soils after harvesting.[] Vitamin B 12 deficiency causes anaemia, fatigue, mood disturbance and other neuropsychiatric and neurological complications.[]

  • Progressive Familial Intrahepatic Cholestasis

    Physical exam Remarkable findings on examination include: Icterus Hepatosplenomegaly Hyperpigmentation Growth retardation Shiny nails The newborn with unexplainable cholestasis[] Both patients had normal gamma-glutamyl transpeptidase levels, but showed severe pruritus with sleep disturbance, cholestasis, jaundice and growth failure.[] In addition to pruritus, other symptoms include icterus, hepatosplenomegaly, excoriations, hyperpigmentation of the skin, shiny nails, growth retardation, pale stools, and[]

  • Hemochromatosis

    External genital hyperpigmentation was seen in one third of patients, and one fifth had hyperpigmentation of flexural folds, scars, and nipple areolae.[] The main adverse effects are inflammatory reactions at the sites of injection, visual and auditory disturbances, bone growth disturbances, and allergic reactions, including[] PubMed was used to search the following terms: hemochromatosis, hereditary, hyperpigmentation, hypopigmentation, keratosis, melanin, seborrheic, siderosis.[]

  • Acanthosis Nigricans

    He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa.[] A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans.[] This is part II of a two-part article on hyperpigmentation in adults.[]

  • Hyperthyroidism

    Reactive hyperpigmentation of the skin and mucous membranes may be found in Addison's disease and hyperthyroidism.[] Menstrual disturbance (decreased flow) Impaired fertility Mental disturbances Sleep disturbances (including insomnia) It is very important to keep in mind that the symptoms[] Tachycardia, irregular pulse (in atrial fibrillation), dyspnea, orthopnea and peripheral edema (in heart failure) Cutaneous Onycholysis (Plummer nails), patchy or generalized hyperpigmentation[]

  • Adenoma

    […] cardiomegaly, heat intolerance, weight gain ACTH ( 20%) Cushing's disease : central obesity (moon facies, buffalo hump), thin skin with striae, hirsutism Nelson's syndrome : hyperpigmentation[] […] control and low risk for pituitary function disturbance or visual apparatus injuries.[] […] the tracheobronchial tree Paraneoplastic involvement Endocrinopathies associated with bronchial carcinoids include Cushing syndrome (with increased corticotropin levels), hyperpigmentation[]

  • Rothmund Thomson Syndrome

    Rothmund-Thomson syndrome (OMIM #268400) is a severe autosomal recessive genodermatosis: characterised by growth retardation, hyperpigmentation and frequently accompanied[] Rothmund syndrome - atrophy, pigmentation, and telangiectasia of the skin, usually with juvenile cataract, saddle nose, congenital bone defects, disturbance of hair growth[] He was admitted when he was 26 months old because of short stature, dehydration, metabolic acidosis, hyperpigmentation, and typical skin lesions.[]

  • Pernicious Anemia

    Physical examination revealed hypotension and marked hyperpigmentation. Laboratory testing showed hyponatremia, hyperkaliemia and severe normocytic anemia.[] Vitamin B 12 deficiency causes anaemia, fatigue, mood disturbance and other neuropsychiatric and neurological complications.[] […] estimates among the general population range from 1.5 to 15%. 1–4 Adequate treatment is essential as vitamin B 12 is necessary for the development of red blood cells, normal growth[]

  • Celiac Disease

    […] symmetrical, grouped polymorphic lesions consisting of erythema, urticarial plaques, papules, herpetiform vesiculae, and blisters followed by erosions, excoriations, and hyperpigmentation[] Advanced disease may be characterized by anemia, osteoporosis, vision disturbances, or amenorrhea (absence of menstruation in women).[] disturbances, and myopathy) in 25 out of 60 patients.[]

  • Systemic Scleroderma

    […] severe type of systemic scleroderma with hyperpigmentation, especially male and older patients, and in unexposed portions of the female group without hyperpigmentation.[] Increased collagen production or disturbances in its degradation can cause excessive collagen deposition in tissues.[] Abstract Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC) patients.[]

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